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Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus.
Biol Pharm Bull. 2012; 35(11):2036-42.BP

Abstract

The papain-like protease (PL(pro)), which controls replication of the severe acute respiratory syndrome coronavirus (SARS-CoV), has been identified as a potential drug target for the treatment of SARS. An intensive hunt for effective anti-SARS drugs has been undertaken by screening for natural product inhibitors that target SARS-CoV PL(pro). In this study, diarylheptanoids 1-9 were isolated from Alnus japonica, and the inhibitory activities of these compounds against PL(pro) were determined. Of the isolated diarylheptanoids, hirsutenone (2) showed the most potent PL(pro) inhibitory activity, with an inhibitory concentration (IC(50)) value of 4.1 µM. Structure-activity analysis showed that catechol and α,β-unsaturated carbonyl moiety in the molecule were the key requirement for SARS-CoV cysteine protease inhibition.

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Authors+Show Affiliations

Park JY
Infection Control Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup 580–185, Republic of Korea.
Jeong HJ
No affiliation info available
Kim JH
No affiliation info available
Kim YM
No affiliation info available
Park SJ
No affiliation info available
Kim D
No affiliation info available
Park KH
No affiliation info available
Lee WS
No affiliation info available
Ryu YB
No affiliation info available

MeSH

AlnusAntiviral AgentsCysteine EndopeptidasesDiarylheptanoidsEscherichia coliPlant BarkProtease InhibitorsStructure-Activity RelationshipViral Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22971649

Citation

Park, Ji-Young, et al. "Diarylheptanoids From Alnus Japonica Inhibit Papain-like Protease of Severe Acute Respiratory Syndrome Coronavirus." Biological & Pharmaceutical Bulletin, vol. 35, no. 11, 2012, pp. 2036-42.
Park JY, Jeong HJ, Kim JH, et al. Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus. Biol Pharm Bull. 2012;35(11):2036-42.
Park, J. Y., Jeong, H. J., Kim, J. H., Kim, Y. M., Park, S. J., Kim, D., Park, K. H., Lee, W. S., & Ryu, Y. B. (2012). Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus. Biological & Pharmaceutical Bulletin, 35(11), 2036-42.
Park JY, et al. Diarylheptanoids From Alnus Japonica Inhibit Papain-like Protease of Severe Acute Respiratory Syndrome Coronavirus. Biol Pharm Bull. 2012;35(11):2036-42. PubMed PMID: 22971649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus. AU - Park,Ji-Young, AU - Jeong,Hyung Jae, AU - Kim,Jang Hoon, AU - Kim,Young Min, AU - Park,Su-Jin, AU - Kim,Doman, AU - Park,Ki Hun, AU - Lee,Woo Song, AU - Ryu,Young Bae, Y1 - 2012/09/03/ PY - 2012/9/14/entrez PY - 2012/9/14/pubmed PY - 2013/4/5/medline SP - 2036 EP - 42 JF - Biological & pharmaceutical bulletin JO - Biol. Pharm. Bull. VL - 35 IS - 11 N2 - The papain-like protease (PL(pro)), which controls replication of the severe acute respiratory syndrome coronavirus (SARS-CoV), has been identified as a potential drug target for the treatment of SARS. An intensive hunt for effective anti-SARS drugs has been undertaken by screening for natural product inhibitors that target SARS-CoV PL(pro). In this study, diarylheptanoids 1-9 were isolated from Alnus japonica, and the inhibitory activities of these compounds against PL(pro) were determined. Of the isolated diarylheptanoids, hirsutenone (2) showed the most potent PL(pro) inhibitory activity, with an inhibitory concentration (IC(50)) value of 4.1 µM. Structure-activity analysis showed that catechol and α,β-unsaturated carbonyl moiety in the molecule were the key requirement for SARS-CoV cysteine protease inhibition. SN - 1347-5215 UR - https://www.unboundmedicine.com/medline/citation/22971649/Diarylheptanoids_from_Alnus_japonica_inhibit_papain_like_protease_of_severe_acute_respiratory_syndrome_coronavirus_ L2 - http://joi.jlc.jst.go.jp/DN/JST.JSTAGE/bpb/b12-00623?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -