Citation
Park, Ji-Young, et al. "Diarylheptanoids From Alnus Japonica Inhibit Papain-like Protease of Severe Acute Respiratory Syndrome Coronavirus." Biological & Pharmaceutical Bulletin, vol. 35, no. 11, 2012, pp. 2036-42.
Park JY, Jeong HJ, Kim JH, et al. Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus. Biol Pharm Bull. 2012;35(11):2036-42.
Park, J. Y., Jeong, H. J., Kim, J. H., Kim, Y. M., Park, S. J., Kim, D., Park, K. H., Lee, W. S., & Ryu, Y. B. (2012). Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus. Biological & Pharmaceutical Bulletin, 35(11), 2036-42.
Park JY, et al. Diarylheptanoids From Alnus Japonica Inhibit Papain-like Protease of Severe Acute Respiratory Syndrome Coronavirus. Biol Pharm Bull. 2012;35(11):2036-42. PubMed PMID: 22971649.
TY - JOUR
T1 - Diarylheptanoids from Alnus japonica inhibit papain-like protease of severe acute respiratory syndrome coronavirus.
AU - Park,Ji-Young,
AU - Jeong,Hyung Jae,
AU - Kim,Jang Hoon,
AU - Kim,Young Min,
AU - Park,Su-Jin,
AU - Kim,Doman,
AU - Park,Ki Hun,
AU - Lee,Woo Song,
AU - Ryu,Young Bae,
Y1 - 2012/09/03/
PY - 2012/9/14/entrez
PY - 2012/9/14/pubmed
PY - 2013/4/5/medline
SP - 2036
EP - 42
JF - Biological & pharmaceutical bulletin
JO - Biol Pharm Bull
VL - 35
IS - 11
N2 - The papain-like protease (PL(pro)), which controls replication of the severe acute respiratory syndrome coronavirus (SARS-CoV), has been identified as a potential drug target for the treatment of SARS. An intensive hunt for effective anti-SARS drugs has been undertaken by screening for natural product inhibitors that target SARS-CoV PL(pro). In this study, diarylheptanoids 1-9 were isolated from Alnus japonica, and the inhibitory activities of these compounds against PL(pro) were determined. Of the isolated diarylheptanoids, hirsutenone (2) showed the most potent PL(pro) inhibitory activity, with an inhibitory concentration (IC(50)) value of 4.1 µM. Structure-activity analysis showed that catechol and α,β-unsaturated carbonyl moiety in the molecule were the key requirement for SARS-CoV cysteine protease inhibition.
SN - 1347-5215
UR - https://www.unboundmedicine.com/medline/citation/22971649/Diarylheptanoids_from_Alnus_japonica_inhibit_papain_like_protease_of_severe_acute_respiratory_syndrome_coronavirus_
L2 - http://joi.jlc.jst.go.jp/DN/JST.JSTAGE/bpb/b12-00623?lang=en&from=PubMed
DB - PRIME
DP - Unbound Medicine
ER -