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Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. ghq208.
Chem Pharm Bull (Tokyo). 2012; 60(11):1458-60.CP

Abstract

One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. ghq208. The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds (2, 3) exhibited moderate cytotoxicities against the HepG2 cell line with IC(50) values of 11.3 and 13.2 µM, respectively.

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Authors+Show Affiliations

Gao H
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P R China.
Zhang L
No affiliation info available
Zhu T
No affiliation info available
Gu Q
No affiliation info available
Li D
No affiliation info available

MeSH

4-QuinolonesAlkaloidsAntineoplastic AgentsCell SurvivalHep G2 CellsHumansInhibitory Concentration 50Liver NeoplasmsPenicilliumPyrroles

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22971874

Citation

Gao, Huquan, et al. "Unusual Pyrrolyl 4-quinolinone Alkaloids From the Marine-derived Fungus Penicillium Sp. Ghq208." Chemical & Pharmaceutical Bulletin, vol. 60, no. 11, 2012, pp. 1458-60.
Gao H, Zhang L, Zhu T, et al. Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. ghq208. Chem Pharm Bull (Tokyo). 2012;60(11):1458-60.
Gao, H., Zhang, L., Zhu, T., Gu, Q., & Li, D. (2012). Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. ghq208. Chemical & Pharmaceutical Bulletin, 60(11), 1458-60.
Gao H, et al. Unusual Pyrrolyl 4-quinolinone Alkaloids From the Marine-derived Fungus Penicillium Sp. Ghq208. Chem Pharm Bull (Tokyo). 2012;60(11):1458-60. PubMed PMID: 22971874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unusual pyrrolyl 4-quinolinone alkaloids from the marine-derived fungus Penicillium sp. ghq208. AU - Gao,Huquan, AU - Zhang,Lianqing, AU - Zhu,Tianjiao, AU - Gu,Qianqun, AU - Li,Dehai, Y1 - 2012/09/04/ PY - 2012/9/14/entrez PY - 2012/9/14/pubmed PY - 2013/4/6/medline SP - 1458 EP - 60 JF - Chemical & pharmaceutical bulletin JO - Chem Pharm Bull (Tokyo) VL - 60 IS - 11 N2 - One new pyrrolyl 4-quinolinone alkaloid, penicinoline E (1), together with three known deriverites, methyl-penicinoline (2), penicinoline (3), and quinolactacide (4), were isolated from the marine-derived fungus Penicillium sp. ghq208. The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds (2, 3) exhibited moderate cytotoxicities against the HepG2 cell line with IC(50) values of 11.3 and 13.2 µM, respectively. SN - 1347-5223 UR - https://www.unboundmedicine.com/medline/citation/22971874/Unusual_pyrrolyl_4_quinolinone_alkaloids_from_the_marine_derived_fungus_Penicillium_sp__ghq208_ L2 - https://joi.jlc.jst.go.jp/DN/JST.JSTAGE/cpb/c12-00487?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -