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False-positive amphetamine/ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (CEDIA) and ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (DRI) test results with fenofibrate.
Ther Drug Monit. 2012 Oct; 34(5):493-5.TD

Abstract

This case report describes a false-positive amphetamine/ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] and ecstasy (MDMA) screen after therapeutic use of antihyperlipidemic drug, fenofibrate. A 60-year-old male patient was admitted to inpatient psychiatry unit with the diagnosis of alcohol dependency. He was prescribed diazepam 30 mg/day, thiamine 300 mg/day, and naltrexone 50 mg/day. He had also been using fenofibrate 267 mg/day for 3 years for hyperlipidemia and trazodone 100 mg/day for 5 months for insomnia. On routine, urine drugs-of-abuse screening amphetamine/MDMA (CEDIA) test was positive for 4 different occasions and MDMA (DRI) test was positive on 5 different occasions. Gas chromatography/mass spectrometry confirmation of the first positive 3 samples were negative for amphetamine and MDMA. After discontinuation of fenofibrate, amphetamine/MDMA, and MDMA immunoassay results turned out to be negative. Caution should be given to interpretation of amphetamine/MDMA (CEDIA) and MDMA (DRI) tests in patients taking fenofibrate. Specific confirmation with a suitable method should be used to prevent erroneous interpretations.

Authors+Show Affiliations

Department of Pharmacology, Clinical Pharmacology, and Toxicology Unit, Izmir Katip Celebi University Faculty of Medicine, Ataturk Training and Research Hospital, Izmir, Turkey. seawise@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

22972534

Citation

Kaplan, Yusuf Cem, et al. "False-positive Amphetamine/ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (CEDIA) and Ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (DRI) Test Results With Fenofibrate." Therapeutic Drug Monitoring, vol. 34, no. 5, 2012, pp. 493-5.
Kaplan YC, Erol A, Karadaş B. False-positive amphetamine/ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (CEDIA) and ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (DRI) test results with fenofibrate. Ther Drug Monit. 2012;34(5):493-5.
Kaplan, Y. C., Erol, A., & Karadaş, B. (2012). False-positive amphetamine/ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (CEDIA) and ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (DRI) test results with fenofibrate. Therapeutic Drug Monitoring, 34(5), 493-5. https://doi.org/10.1097/FTD.0b013e3182690127
Kaplan YC, Erol A, Karadaş B. False-positive Amphetamine/ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (CEDIA) and Ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (DRI) Test Results With Fenofibrate. Ther Drug Monit. 2012;34(5):493-5. PubMed PMID: 22972534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - False-positive amphetamine/ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (CEDIA) and ecstasy (MDMA/3,4-methylenedioxymethamphetamine) (DRI) test results with fenofibrate. AU - Kaplan,Yusuf Cem, AU - Erol,Almla, AU - Karadaş,Barş, PY - 2012/9/14/entrez PY - 2012/9/14/pubmed PY - 2013/5/15/medline SP - 493 EP - 5 JF - Therapeutic drug monitoring JO - Ther Drug Monit VL - 34 IS - 5 N2 - This case report describes a false-positive amphetamine/ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] and ecstasy (MDMA) screen after therapeutic use of antihyperlipidemic drug, fenofibrate. A 60-year-old male patient was admitted to inpatient psychiatry unit with the diagnosis of alcohol dependency. He was prescribed diazepam 30 mg/day, thiamine 300 mg/day, and naltrexone 50 mg/day. He had also been using fenofibrate 267 mg/day for 3 years for hyperlipidemia and trazodone 100 mg/day for 5 months for insomnia. On routine, urine drugs-of-abuse screening amphetamine/MDMA (CEDIA) test was positive for 4 different occasions and MDMA (DRI) test was positive on 5 different occasions. Gas chromatography/mass spectrometry confirmation of the first positive 3 samples were negative for amphetamine and MDMA. After discontinuation of fenofibrate, amphetamine/MDMA, and MDMA immunoassay results turned out to be negative. Caution should be given to interpretation of amphetamine/MDMA (CEDIA) and MDMA (DRI) tests in patients taking fenofibrate. Specific confirmation with a suitable method should be used to prevent erroneous interpretations. SN - 1536-3694 UR - https://www.unboundmedicine.com/medline/citation/22972534/False_positive_amphetamine/ecstasy__MDMA/34_methylenedioxymethamphetamine___CEDIA__and_ecstasy__MDMA/34_methylenedioxymethamphetamine___DRI__test_results_with_fenofibrate_ L2 - https://doi.org/10.1097/FTD.0b013e3182690127. DB - PRIME DP - Unbound Medicine ER -