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Isolation and antioxidant activity of zeylaniin A, a new macrocyclic ellagitannin from Syzygium zeylanicum leaves.
J Agric Food Chem. 2012 Oct 17; 60(41):10263-9.JA

Abstract

Methanol extract obtained from Syzygium zeylanicum leaves exhibited potent antioxidant activity. The water extract obtained from this methanol extract by sequential extraction with hexane, chloroform, ethylacetate, and n-butanol also showed the strongest antioxidant activity among extracts. This water extract was further fractionated by column chromatography with various concentrations of methanol solutions. Among the 6 resultant fractions, the fraction developed with 20% methanol exhibited the most potent antioxidant activity. The one peak among the three major HPLC peaks in this fraction was isolated and purified using a preparative HPLC. The structure of a pure compound was elucidated as a novel macrocyclic ellagitannin using a (1)H/(13)C NMR and a high-resolution electrospray ionization mass spectrometer. This newly isolated compound, which was named zeylaniin A, exhibited potent antioxidant activities in the assays of DPPH, oxygen radical absorbance capacity, and malonadehyde/gas chromatography. S. zeylanicum leaves can be a possible source of natural antioxidants.

Authors+Show Affiliations

Institute of Environmental Science for Human Life, Ochanomizu University, Bunkyo-Ku, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22973981

Citation

Nomi, Yuri, et al. "Isolation and Antioxidant Activity of Zeylaniin A, a New Macrocyclic Ellagitannin From Syzygium Zeylanicum Leaves." Journal of Agricultural and Food Chemistry, vol. 60, no. 41, 2012, pp. 10263-9.
Nomi Y, Shimizu S, Sone Y, et al. Isolation and antioxidant activity of zeylaniin A, a new macrocyclic ellagitannin from Syzygium zeylanicum leaves. J Agric Food Chem. 2012;60(41):10263-9.
Nomi, Y., Shimizu, S., Sone, Y., Tuyet, M. T., Gia, T. P., Kamiyama, M., Shibamoto, T., Shindo, K., & Otsuka, Y. (2012). Isolation and antioxidant activity of zeylaniin A, a new macrocyclic ellagitannin from Syzygium zeylanicum leaves. Journal of Agricultural and Food Chemistry, 60(41), 10263-9. https://doi.org/10.1021/jf302977n
Nomi Y, et al. Isolation and Antioxidant Activity of Zeylaniin A, a New Macrocyclic Ellagitannin From Syzygium Zeylanicum Leaves. J Agric Food Chem. 2012 Oct 17;60(41):10263-9. PubMed PMID: 22973981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation and antioxidant activity of zeylaniin A, a new macrocyclic ellagitannin from Syzygium zeylanicum leaves. AU - Nomi,Yuri, AU - Shimizu,Saki, AU - Sone,Yasuko, AU - Tuyet,Mai Truong, AU - Gia,Tien Pham, AU - Kamiyama,Masumi, AU - Shibamoto,Takayuki, AU - Shindo,Kazutoshi, AU - Otsuka,Yuzuru, Y1 - 2012/10/03/ PY - 2012/9/15/entrez PY - 2012/9/15/pubmed PY - 2013/3/27/medline SP - 10263 EP - 9 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 60 IS - 41 N2 - Methanol extract obtained from Syzygium zeylanicum leaves exhibited potent antioxidant activity. The water extract obtained from this methanol extract by sequential extraction with hexane, chloroform, ethylacetate, and n-butanol also showed the strongest antioxidant activity among extracts. This water extract was further fractionated by column chromatography with various concentrations of methanol solutions. Among the 6 resultant fractions, the fraction developed with 20% methanol exhibited the most potent antioxidant activity. The one peak among the three major HPLC peaks in this fraction was isolated and purified using a preparative HPLC. The structure of a pure compound was elucidated as a novel macrocyclic ellagitannin using a (1)H/(13)C NMR and a high-resolution electrospray ionization mass spectrometer. This newly isolated compound, which was named zeylaniin A, exhibited potent antioxidant activities in the assays of DPPH, oxygen radical absorbance capacity, and malonadehyde/gas chromatography. S. zeylanicum leaves can be a possible source of natural antioxidants. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/22973981/Isolation_and_antioxidant_activity_of_zeylaniin_A_a_new_macrocyclic_ellagitannin_from_Syzygium_zeylanicum_leaves_ L2 - https://doi.org/10.1021/jf302977n DB - PRIME DP - Unbound Medicine ER -