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Oesophageal mucosal intercellular space diameter and reflux pattern in childhood erosive and non-erosive reflux disease.
Dig Liver Dis. 2012 Dec; 44(12):981-7.DL

Abstract

BACKGROUND AND AIMS

We sought to compare intercellular space diameter in children with non-erosive and erosive reflux disease, and a control group. We also aimed to characterize the reflux pattern in erosive and non-erosive reflux disease patients, and to explore the relationship between intercellular space diameter values and reflux parameters.

METHODS

Twenty-four children with non-erosive reflux disease, 20 with erosive reflux disease, and 10 controls were prospectively studied. All patients and controls underwent upper endoscopy. Biopsies were taken at 2-3 cm above the Z-line, and intercellular space diameter was measured using transmission electron microscopy. Non-erosive and erosive reflux disease patients underwent impedance-pH monitoring.

RESULTS

Mean intercellular space diameter values were significantly higher in both non-erosive (0.9 ± 0.2 μm) and erosive reflux disease (1 ± 0.2 μm) compared to controls (0.5 ± 0.2 μm, p<0.01). No difference was found between the two patient groups. Acid exposure time, the number of acid, weakly acidic and weakly alkaline reflux events did not differ between the two patient groups. No difference was found in the mean intercellular space diameter between non-erosive reflux disease children with and without abnormal acid exposure time (1 ± 0.3 vs. 0.9 ± 0.2 μm). No correlation was found between any reflux parameter and intercellular space diameter values.

CONCLUSIONS

Dilated intercellular space diameter seems to be a useful and objective marker of oesophageal damage in paediatric gastro-oesophageal reflux disease, regardless of acid exposure. In childhood, different gastro-oesophageal reflux disease phenotypes cannot be discriminated on the basis of reflux pattern.

Authors+Show Affiliations

Division of Pediatric Gastroenterology and Hepatology, Sapienza University of Rome, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22974565

Citation

Mancini, Valentina, et al. "Oesophageal Mucosal Intercellular Space Diameter and Reflux Pattern in Childhood Erosive and Non-erosive Reflux Disease." Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, vol. 44, no. 12, 2012, pp. 981-7.
Mancini V, Ribolsi M, Gentile M, et al. Oesophageal mucosal intercellular space diameter and reflux pattern in childhood erosive and non-erosive reflux disease. Dig Liver Dis. 2012;44(12):981-7.
Mancini, V., Ribolsi, M., Gentile, M., de'Angelis, G., Bizzarri, B., Lindley, K. J., Cucchiara, S., Cicala, M., & Borrelli, O. (2012). Oesophageal mucosal intercellular space diameter and reflux pattern in childhood erosive and non-erosive reflux disease. Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 44(12), 981-7. https://doi.org/10.1016/j.dld.2012.08.001
Mancini V, et al. Oesophageal Mucosal Intercellular Space Diameter and Reflux Pattern in Childhood Erosive and Non-erosive Reflux Disease. Dig Liver Dis. 2012;44(12):981-7. PubMed PMID: 22974565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oesophageal mucosal intercellular space diameter and reflux pattern in childhood erosive and non-erosive reflux disease. AU - Mancini,Valentina, AU - Ribolsi,Mentore, AU - Gentile,Massimo, AU - de'Angelis,Gianluigi, AU - Bizzarri,Barbara, AU - Lindley,Keith J, AU - Cucchiara,Salvatore, AU - Cicala,Michele, AU - Borrelli,Osvaldo, Y1 - 2012/09/10/ PY - 2012/04/26/received PY - 2012/07/28/revised PY - 2012/08/02/accepted PY - 2012/9/15/entrez PY - 2012/9/15/pubmed PY - 2013/4/16/medline SP - 981 EP - 7 JF - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JO - Dig Liver Dis VL - 44 IS - 12 N2 - BACKGROUND AND AIMS: We sought to compare intercellular space diameter in children with non-erosive and erosive reflux disease, and a control group. We also aimed to characterize the reflux pattern in erosive and non-erosive reflux disease patients, and to explore the relationship between intercellular space diameter values and reflux parameters. METHODS: Twenty-four children with non-erosive reflux disease, 20 with erosive reflux disease, and 10 controls were prospectively studied. All patients and controls underwent upper endoscopy. Biopsies were taken at 2-3 cm above the Z-line, and intercellular space diameter was measured using transmission electron microscopy. Non-erosive and erosive reflux disease patients underwent impedance-pH monitoring. RESULTS: Mean intercellular space diameter values were significantly higher in both non-erosive (0.9 ± 0.2 μm) and erosive reflux disease (1 ± 0.2 μm) compared to controls (0.5 ± 0.2 μm, p<0.01). No difference was found between the two patient groups. Acid exposure time, the number of acid, weakly acidic and weakly alkaline reflux events did not differ between the two patient groups. No difference was found in the mean intercellular space diameter between non-erosive reflux disease children with and without abnormal acid exposure time (1 ± 0.3 vs. 0.9 ± 0.2 μm). No correlation was found between any reflux parameter and intercellular space diameter values. CONCLUSIONS: Dilated intercellular space diameter seems to be a useful and objective marker of oesophageal damage in paediatric gastro-oesophageal reflux disease, regardless of acid exposure. In childhood, different gastro-oesophageal reflux disease phenotypes cannot be discriminated on the basis of reflux pattern. SN - 1878-3562 UR - https://www.unboundmedicine.com/medline/citation/22974565/Oesophageal_mucosal_intercellular_space_diameter_and_reflux_pattern_in_childhood_erosive_and_non_erosive_reflux_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1590-8658(12)00290-3 DB - PRIME DP - Unbound Medicine ER -