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Relationships of decreased lung function with metabolic syndrome and obstructive sleep apnea in Japanese males.
Intern Med. 2012; 51(17):2291-7.IM

Abstract

OBJECTIVE

Decreased lung function as assessed by forced vital capacity (FVC) and forced expiratory volume in one second (FEV(1)) is shown to be associated with cardiovascular morbidity and mortality. Although the underlying mechanisms for this association remain unknown, metabolic syndrome and obstructive sleep apnea (OSA) may have a role. We analyzed the relationships between metabolic syndrome and OSA in a cross-sectional health survey of middle-aged male employees.

METHODS

In this secondary analysis, we re-analyzed the relationships of lung function determined by spirometry with metabolic syndrome and OSA based on the respiratory disturbance index (RDI) with a type 3 portable monitor.

RESULTS

We analyzed 273 subjects. Independent of age, body mass index (BMI) and smoking, quartiles for lower FVC and FEV(1) were associated with a higher risk of metabolic syndrome compared with quartiles for the highest FVC and FEV(1), respectively. A similar trend was observed regarding the risk associated with waist circumference, and in FVC cases, dyslipidemia. The risk of hyperglycemia was significantly higher in quartiles for the second lowest FVC and FEV(1) than in quartiles for the highest FVC and FEV(1), respectively. A significant trend for an increase in RDI was observed in accordance with quartiles for lower FVC, but not FEV(1).

CONCLUSION

There was a significant relationship between lung function impairment and metabolic syndrome through mainly abdominal obesity, partially through hyperglycemia, and also through dyslipidemia, but only with respect to restrictive lung function. Restrictive lung function was also related to OSA. This epidemiologic evidence may indicate underlying mechanisms between decreased lung function and cardiovascular risk.

Authors+Show Affiliations

Department of Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22975537

Citation

Yoshimura, Chikara, et al. "Relationships of Decreased Lung Function With Metabolic Syndrome and Obstructive Sleep Apnea in Japanese Males." Internal Medicine (Tokyo, Japan), vol. 51, no. 17, 2012, pp. 2291-7.
Yoshimura C, Oga T, Chin K, et al. Relationships of decreased lung function with metabolic syndrome and obstructive sleep apnea in Japanese males. Intern Med. 2012;51(17):2291-7.
Yoshimura, C., Oga, T., Chin, K., Takegami, M., Takahashi, K., Sumi, K., Nakamura, T., Nakayama-Ashida, Y., Minami, I., Horita, S., Oka, Y., Wakamura, T., Fukuhara, S., Mishima, M., & Kadotani, H. (2012). Relationships of decreased lung function with metabolic syndrome and obstructive sleep apnea in Japanese males. Internal Medicine (Tokyo, Japan), 51(17), 2291-7.
Yoshimura C, et al. Relationships of Decreased Lung Function With Metabolic Syndrome and Obstructive Sleep Apnea in Japanese Males. Intern Med. 2012;51(17):2291-7. PubMed PMID: 22975537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships of decreased lung function with metabolic syndrome and obstructive sleep apnea in Japanese males. AU - Yoshimura,Chikara, AU - Oga,Toru, AU - Chin,Kazuo, AU - Takegami,Misa, AU - Takahashi,Ken-ichi, AU - Sumi,Kensuke, AU - Nakamura,Takaya, AU - Nakayama-Ashida,Yukiyo, AU - Minami,Itsunari, AU - Horita,Sachiko, AU - Oka,Yasunori, AU - Wakamura,Tomoko, AU - Fukuhara,Shunichi, AU - Mishima,Michiaki, AU - Kadotani,Hiroshi, Y1 - 2012/09/01/ PY - 2012/9/15/entrez PY - 2012/9/15/pubmed PY - 2013/4/11/medline SP - 2291 EP - 7 JF - Internal medicine (Tokyo, Japan) JO - Intern Med VL - 51 IS - 17 N2 - OBJECTIVE: Decreased lung function as assessed by forced vital capacity (FVC) and forced expiratory volume in one second (FEV(1)) is shown to be associated with cardiovascular morbidity and mortality. Although the underlying mechanisms for this association remain unknown, metabolic syndrome and obstructive sleep apnea (OSA) may have a role. We analyzed the relationships between metabolic syndrome and OSA in a cross-sectional health survey of middle-aged male employees. METHODS: In this secondary analysis, we re-analyzed the relationships of lung function determined by spirometry with metabolic syndrome and OSA based on the respiratory disturbance index (RDI) with a type 3 portable monitor. RESULTS: We analyzed 273 subjects. Independent of age, body mass index (BMI) and smoking, quartiles for lower FVC and FEV(1) were associated with a higher risk of metabolic syndrome compared with quartiles for the highest FVC and FEV(1), respectively. A similar trend was observed regarding the risk associated with waist circumference, and in FVC cases, dyslipidemia. The risk of hyperglycemia was significantly higher in quartiles for the second lowest FVC and FEV(1) than in quartiles for the highest FVC and FEV(1), respectively. A significant trend for an increase in RDI was observed in accordance with quartiles for lower FVC, but not FEV(1). CONCLUSION: There was a significant relationship between lung function impairment and metabolic syndrome through mainly abdominal obesity, partially through hyperglycemia, and also through dyslipidemia, but only with respect to restrictive lung function. Restrictive lung function was also related to OSA. This epidemiologic evidence may indicate underlying mechanisms between decreased lung function and cardiovascular risk. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/22975537/Relationships_of_decreased_lung_function_with_metabolic_syndrome_and_obstructive_sleep_apnea_in_Japanese_males_ L2 - https://joi.jlc.jst.go.jp/DN/JST.JSTAGE/internalmedicine/51.7427?from=PubMed DB - PRIME DP - Unbound Medicine ER -