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Urine neutrophil gelatinase-associated lipocalin and kidney injury in children with focal segmental glomerulosclerosis.
Iran J Kidney Dis. 2012 Sep; 6(5):355-60.IJ

Abstract

INTRODUCTION

Neutrophil gelatinase-associated lipocalin (NGAL) is proposed as a marker of chronic kidney disease (CKD). This study was designed to find whether there is a correlation between urine NGAL and progression of kidney damage in children with focal segmental glomerulosclerosis (FSGS).

MATERIALS AND METHODS

Data were collected at the initial diagnosis of FSGS and after 12 months of treatment based on the Mendoza protocol. Twelve children with FSGS and 15 healthy children were included. Urine NGAL was assessed at the initiation of the study in the two groups and after 1 year of receiving the treatment in the FSGS group.

RESULTS

Urine NGAL was elevated in the FSGS group (350.0 ± 67.2 ng/mL) as compared to that in the control group (9.3 ± 3.8 ng/mL; P < .001), and there was a significant decline after 1 year (180.0 ± 45.9 ng/mL) in the FSGS group (P < .001). There were significant inverse correlations between urine NGAL and estimated creatinine clearance in the FSGS patients both at diagnosis (r = -0.589, P = .03), and after 1 year (r = -0.76, P = .009). There was a significant correlation between urine NGAL and urinary protein excretion in FSGS patients at diagnosis (r = 0.628, P = .005).

CONCLUSIONS

Urine NGAL in children with FSGS can be used as a marker of progression of kidney damage as expressed in its positive correlation with both declining in glomerular filtration rate and the level of proteinuria even in those with remission.

Authors+Show Affiliations

Department of Pediatrics, Zagazig University, Zagazig, Egypt. dody5176@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22976261

Citation

Youssef, Doaa Mohammed, and Amal Abdelazeem El-Shal. "Urine Neutrophil Gelatinase-associated Lipocalin and Kidney Injury in Children With Focal Segmental Glomerulosclerosis." Iranian Journal of Kidney Diseases, vol. 6, no. 5, 2012, pp. 355-60.
Youssef DM, El-Shal AA. Urine neutrophil gelatinase-associated lipocalin and kidney injury in children with focal segmental glomerulosclerosis. Iran J Kidney Dis. 2012;6(5):355-60.
Youssef, D. M., & El-Shal, A. A. (2012). Urine neutrophil gelatinase-associated lipocalin and kidney injury in children with focal segmental glomerulosclerosis. Iranian Journal of Kidney Diseases, 6(5), 355-60.
Youssef DM, El-Shal AA. Urine Neutrophil Gelatinase-associated Lipocalin and Kidney Injury in Children With Focal Segmental Glomerulosclerosis. Iran J Kidney Dis. 2012;6(5):355-60. PubMed PMID: 22976261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urine neutrophil gelatinase-associated lipocalin and kidney injury in children with focal segmental glomerulosclerosis. AU - Youssef,Doaa Mohammed, AU - El-Shal,Amal Abdelazeem, PY - 2012/01/07/received PY - 2012/04/18/accepted PY - 2012/03/25/revised PY - 2012/9/15/entrez PY - 2012/9/15/pubmed PY - 2013/3/2/medline SP - 355 EP - 60 JF - Iranian journal of kidney diseases JO - Iran J Kidney Dis VL - 6 IS - 5 N2 - INTRODUCTION: Neutrophil gelatinase-associated lipocalin (NGAL) is proposed as a marker of chronic kidney disease (CKD). This study was designed to find whether there is a correlation between urine NGAL and progression of kidney damage in children with focal segmental glomerulosclerosis (FSGS). MATERIALS AND METHODS: Data were collected at the initial diagnosis of FSGS and after 12 months of treatment based on the Mendoza protocol. Twelve children with FSGS and 15 healthy children were included. Urine NGAL was assessed at the initiation of the study in the two groups and after 1 year of receiving the treatment in the FSGS group. RESULTS: Urine NGAL was elevated in the FSGS group (350.0 ± 67.2 ng/mL) as compared to that in the control group (9.3 ± 3.8 ng/mL; P < .001), and there was a significant decline after 1 year (180.0 ± 45.9 ng/mL) in the FSGS group (P < .001). There were significant inverse correlations between urine NGAL and estimated creatinine clearance in the FSGS patients both at diagnosis (r = -0.589, P = .03), and after 1 year (r = -0.76, P = .009). There was a significant correlation between urine NGAL and urinary protein excretion in FSGS patients at diagnosis (r = 0.628, P = .005). CONCLUSIONS: Urine NGAL in children with FSGS can be used as a marker of progression of kidney damage as expressed in its positive correlation with both declining in glomerular filtration rate and the level of proteinuria even in those with remission. SN - 1735-8604 UR - https://www.unboundmedicine.com/medline/citation/22976261/Urine_neutrophil_gelatinase_associated_lipocalin_and_kidney_injury_in_children_with_focal_segmental_glomerulosclerosis_ L2 - http://www.ijkd.org/index.php/ijkd/article/view/742/448 DB - PRIME DP - Unbound Medicine ER -