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Vitamin D metabolism and activity as well as genetic variants of the vitamin D receptor (VDR) in chronic kidney disease patients.
J Nephrol. 2013 Jul-Aug; 26(4):636-44.JN

Abstract

For a long time, the role of vitamin D in chronic kidney disease (CKD) received less attention than treating vitamin D metabolism disorders. Low active vitamin D levels represent one of the most important factors in the pathophysiology of secondary hyperparathyroidism. For this reason, the administration of active vitamin D compounds is commenced during the course of CKD treatment. Moreover, patients with CKD exhibit a high prevalence of hypovitaminosis of 25-hydroxyvitamin D (25[OH]D) unrelated to vitamin D intake. However, several studies have recently advanced our knowledge about the effects of both the 25(OH)D and 1,25(OH)2D forms of endogenous vitamin D and the possible beneficial effects of vitamin D treatment. These studies add to the already well-known effects of vitamin D on mineral metabolism. Several studies have hypothesized a link between reduced levels of 25-OH D and a greater cardiovascular risk in the general population. Another important aspect of vitamin D metabolism is the existence of polymorphic genetic variants of the vitamin D receptors (VDRs). Most studies have aimed to determine whether VDR polymorphisms are involved in the development of secondary hyperparathyroidism (sHPT).

Authors+Show Affiliations

Units of Nephrology and Dialysis, Clinical Experimental Department of Medicine and Pharmacology, University of Messina, Messina, Italy. santisi@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22976524

Citation

Santoro, Domenico, et al. "Vitamin D Metabolism and Activity as Well as Genetic Variants of the Vitamin D Receptor (VDR) in Chronic Kidney Disease Patients." Journal of Nephrology, vol. 26, no. 4, 2013, pp. 636-44.
Santoro D, Caccamo D, Gagliostro G, et al. Vitamin D metabolism and activity as well as genetic variants of the vitamin D receptor (VDR) in chronic kidney disease patients. J Nephrol. 2013;26(4):636-44.
Santoro, D., Caccamo, D., Gagliostro, G., Ientile, R., Benvenga, S., Bellinghieri, G., & Savica, V. (2013). Vitamin D metabolism and activity as well as genetic variants of the vitamin D receptor (VDR) in chronic kidney disease patients. Journal of Nephrology, 26(4), 636-44. https://doi.org/10.5301/jn.5000203
Santoro D, et al. Vitamin D Metabolism and Activity as Well as Genetic Variants of the Vitamin D Receptor (VDR) in Chronic Kidney Disease Patients. J Nephrol. 2013 Jul-Aug;26(4):636-44. PubMed PMID: 22976524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D metabolism and activity as well as genetic variants of the vitamin D receptor (VDR) in chronic kidney disease patients. AU - Santoro,Domenico, AU - Caccamo,Daniela, AU - Gagliostro,Giorgia, AU - Ientile,Riccardo, AU - Benvenga,Salvatore, AU - Bellinghieri,Guido, AU - Savica,Vincenzo, Y1 - 2012/09/13/ PY - 2012/06/13/accepted PY - 2012/9/15/entrez PY - 2012/9/15/pubmed PY - 2013/11/13/medline SP - 636 EP - 44 JF - Journal of nephrology JO - J Nephrol VL - 26 IS - 4 N2 - For a long time, the role of vitamin D in chronic kidney disease (CKD) received less attention than treating vitamin D metabolism disorders. Low active vitamin D levels represent one of the most important factors in the pathophysiology of secondary hyperparathyroidism. For this reason, the administration of active vitamin D compounds is commenced during the course of CKD treatment. Moreover, patients with CKD exhibit a high prevalence of hypovitaminosis of 25-hydroxyvitamin D (25[OH]D) unrelated to vitamin D intake. However, several studies have recently advanced our knowledge about the effects of both the 25(OH)D and 1,25(OH)2D forms of endogenous vitamin D and the possible beneficial effects of vitamin D treatment. These studies add to the already well-known effects of vitamin D on mineral metabolism. Several studies have hypothesized a link between reduced levels of 25-OH D and a greater cardiovascular risk in the general population. Another important aspect of vitamin D metabolism is the existence of polymorphic genetic variants of the vitamin D receptors (VDRs). Most studies have aimed to determine whether VDR polymorphisms are involved in the development of secondary hyperparathyroidism (sHPT). SN - 1724-6059 UR - https://www.unboundmedicine.com/medline/citation/22976524/Vitamin_D_metabolism_and_activity_as_well_as_genetic_variants_of_the_vitamin_D_receptor__VDR__in_chronic_kidney_disease_patients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=22976524.ui DB - PRIME DP - Unbound Medicine ER -