Tags

Type your tag names separated by a space and hit enter

Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study.
Mov Disord. 2012 Sep 15; 27(11):1418-24.MD

Abstract

Although organochlorines have been reported more frequently in Parkinson's disease (PD) brains than in controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during midlife, represent a population well suited to determining the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. The study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. The prevalence of Lewy pathology was 75% (6 of 8) among brains with any 2 of the 3 compounds, 48.8% (79 of 162) among those with 1, and 32.7% (18 of 55) for those with neither (P = .007 test for trend). Although findings persisted after removing cases with PD and dementia with Lewy bodies and after adjustment for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (P = .013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.

Authors+Show Affiliations

Veterans Affairs Pacific Islands Health Care System, Honolulu, Hawaii 96819, USA. george.ross@va.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

22976848

Citation

Ross, G Webster, et al. "Brain Organochlorines and Lewy Pathology: the Honolulu-Asia Aging Study." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 27, no. 11, 2012, pp. 1418-24.
Ross GW, Duda JE, Abbott RD, et al. Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study. Mov Disord. 2012;27(11):1418-24.
Ross, G. W., Duda, J. E., Abbott, R. D., Pellizzari, E., Petrovitch, H., Miller, D. B., O'Callaghan, J. P., Tanner, C. M., Noorigian, J. V., Masaki, K., Launer, L., & White, L. R. (2012). Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study. Movement Disorders : Official Journal of the Movement Disorder Society, 27(11), 1418-24. https://doi.org/10.1002/mds.25144
Ross GW, et al. Brain Organochlorines and Lewy Pathology: the Honolulu-Asia Aging Study. Mov Disord. 2012 Sep 15;27(11):1418-24. PubMed PMID: 22976848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain organochlorines and Lewy pathology: the Honolulu-Asia Aging Study. AU - Ross,G Webster, AU - Duda,John E, AU - Abbott,Robert D, AU - Pellizzari,Edo, AU - Petrovitch,Helen, AU - Miller,Diane B, AU - O'Callaghan,James P, AU - Tanner,Caroline M, AU - Noorigian,Joseph V, AU - Masaki,Kamal, AU - Launer,Lenore, AU - White,Lon R, Y1 - 2012/09/13/ PY - 2012/03/05/received PY - 2012/06/26/revised PY - 2012/07/17/accepted PY - 2012/9/15/entrez PY - 2012/9/15/pubmed PY - 2013/3/7/medline SP - 1418 EP - 24 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 27 IS - 11 N2 - Although organochlorines have been reported more frequently in Parkinson's disease (PD) brains than in controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during midlife, represent a population well suited to determining the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. The study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found in at least 1 brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. The prevalence of Lewy pathology was 75% (6 of 8) among brains with any 2 of the 3 compounds, 48.8% (79 of 162) among those with 1, and 32.7% (18 of 55) for those with neither (P = .007 test for trend). Although findings persisted after removing cases with PD and dementia with Lewy bodies and after adjustment for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (P = .013), the results were insignificant when correcting for multiple testing. Although consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/22976848/Brain_organochlorines_and_Lewy_pathology:_the_Honolulu_Asia_Aging_Study_ L2 - https://doi.org/10.1002/mds.25144 DB - PRIME DP - Unbound Medicine ER -