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The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells.
Nat Prod Commun. 2012 Aug; 7(8):1007-10.NP

Abstract

In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity.

Authors+Show Affiliations

Arung ET
Department of Forest Product Technology, Faculty of Forestry, Mulawarman University, Samarinda, 75123, Indonesia.
Furuta S
No affiliation info available
Sugamoto K
No affiliation info available
Shimizu K
No affiliation info available
Ishikawa H
No affiliation info available
Matsushita Y
No affiliation info available
Kondo R
No affiliation info available

MeSH

AngelicaAnimalsCell Line, TumorChalconesMelaninsMolecular Structure

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22978217

Citation

Arung, Enos Tangke, et al. "The Inhibitory Effects of Representative Chalcones Contained in Angelica Keiskei On Melanin Biosynthesis in B16 Melanoma Cells." Natural Product Communications, vol. 7, no. 8, 2012, pp. 1007-10.
Arung ET, Furuta S, Sugamoto K, et al. The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells. Nat Prod Commun. 2012;7(8):1007-10.
Arung, E. T., Furuta, S., Sugamoto, K., Shimizu, K., Ishikawa, H., Matsushita, Y., & Kondo, R. (2012). The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells. Natural Product Communications, 7(8), 1007-10.
Arung ET, et al. The Inhibitory Effects of Representative Chalcones Contained in Angelica Keiskei On Melanin Biosynthesis in B16 Melanoma Cells. Nat Prod Commun. 2012;7(8):1007-10. PubMed PMID: 22978217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The inhibitory effects of representative chalcones contained in Angelica keiskei on melanin biosynthesis in B16 melanoma cells. AU - Arung,Enos Tangke, AU - Furuta,Shoko, AU - Sugamoto,Kazuhiro, AU - Shimizu,Kuniyoshi, AU - Ishikawa,Hiroya, AU - Matsushita,Yoh-ichi, AU - Kondo,Ryuichiro, PY - 2012/9/18/entrez PY - 2012/9/18/pubmed PY - 2012/10/12/medline SP - 1007 EP - 10 JF - Natural product communications JO - Nat Prod Commun VL - 7 IS - 8 N2 - In our effort to find new whitening agents, we evaluated the effects of representative chalcones [4-hydroxyderricin (1), xanthoangelol (2), xanthoangelol H (3), deoxyxanthoangelol H (4), and deoxydihydroxanthoangelol H (5)] contained in the stem of Angelica keiskei on tyrosinase and melanin formation in B16 melanoma cells. In addition, the antioxidant effects of these chalcones in ORAC and DPPH assays were also determined. Interestingly, all chalcones (1-5) inhibit melanin formation in B16 melanoma cells, with low cytotoxicity. SN - 1934-578X UR - https://www.unboundmedicine.com/medline/citation/22978217/The_inhibitory_effects_of_representative_chalcones_contained_in_Angelica_keiskei_on_melanin_biosynthesis_in_B16_melanoma_cells_ DB - PRIME DP - Unbound Medicine ER -