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Effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)2 on toxicity induced by mercuric chloride in mice: a comparative study with diphenyl diselenide (PhSe)2.
Environ Toxicol Pharmacol. 2012 Nov; 34(3):985-94.ET

Abstract

The effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)(2) on the toxicity induced by mercuric chloride (HgCl(2)) were investigated and compared with diphenyl diselenide (PhSe)(2). Mice received HgCl(2) for three days and, on the third day, received (PhSe)(2) or (ClPhSe)(2). The results verified that the administration of (ClPhSe)(2) in mice exposed to HgCl(2) increased renal δ-aminolevulinate dehydratase (δ-ALA-D), Na(+), K(+)-ATPase activities and non-protein thiol (NPSH) levels and also decreased thiobarbituric acid-reactive substances (TBARS) and ascorbic acid levels, when compared to mice exposed to HgCl(2)+(PhSe)(2). Plasma and urinary protein, hemoglobin and hematocrit levels and histological parameters were also ameliorated in mice exposed to HgCl(2)+(ClPhSe)(2). In addition, the hepatic damage in mice exposed to HgCl(2)+(PhSe)(2) was reduced in animals exposed to (ClPhSe)(2). To sum up, the introduction of a functional group (chloro) in the aromatic ring of diaryl diselenide reduced the toxicity of this compound in liver and kidney of mice exposed to HgCl(2).

Authors+Show Affiliations

Departamento de Análises Clínicas e Toxicológicas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900 RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22981437

Citation

de Freitas, Mayara L., et al. "Effects of 4,4'-dichloro-diphenyl Diselenide (ClPhSe)2 On Toxicity Induced By Mercuric Chloride in Mice: a Comparative Study With Diphenyl Diselenide (PhSe)2." Environmental Toxicology and Pharmacology, vol. 34, no. 3, 2012, pp. 985-94.
de Freitas ML, da Silva AR, Roman SS, et al. Effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)2 on toxicity induced by mercuric chloride in mice: a comparative study with diphenyl diselenide (PhSe)2. Environ Toxicol Pharmacol. 2012;34(3):985-94.
de Freitas, M. L., da Silva, A. R., Roman, S. S., & Brandão, R. (2012). Effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)2 on toxicity induced by mercuric chloride in mice: a comparative study with diphenyl diselenide (PhSe)2. Environmental Toxicology and Pharmacology, 34(3), 985-94. https://doi.org/10.1016/j.etap.2012.07.007
de Freitas ML, et al. Effects of 4,4'-dichloro-diphenyl Diselenide (ClPhSe)2 On Toxicity Induced By Mercuric Chloride in Mice: a Comparative Study With Diphenyl Diselenide (PhSe)2. Environ Toxicol Pharmacol. 2012;34(3):985-94. PubMed PMID: 22981437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)2 on toxicity induced by mercuric chloride in mice: a comparative study with diphenyl diselenide (PhSe)2. AU - de Freitas,Mayara L, AU - da Silva,Andreia R H, AU - Roman,Silvane S, AU - Brandão,Ricardo, Y1 - 2012/07/31/ PY - 2012/05/18/received PY - 2012/07/17/revised PY - 2012/07/25/accepted PY - 2012/9/18/entrez PY - 2012/9/18/pubmed PY - 2013/4/12/medline SP - 985 EP - 94 JF - Environmental toxicology and pharmacology JO - Environ Toxicol Pharmacol VL - 34 IS - 3 N2 - The effects of 4,4'-dichloro-diphenyl diselenide (ClPhSe)(2) on the toxicity induced by mercuric chloride (HgCl(2)) were investigated and compared with diphenyl diselenide (PhSe)(2). Mice received HgCl(2) for three days and, on the third day, received (PhSe)(2) or (ClPhSe)(2). The results verified that the administration of (ClPhSe)(2) in mice exposed to HgCl(2) increased renal δ-aminolevulinate dehydratase (δ-ALA-D), Na(+), K(+)-ATPase activities and non-protein thiol (NPSH) levels and also decreased thiobarbituric acid-reactive substances (TBARS) and ascorbic acid levels, when compared to mice exposed to HgCl(2)+(PhSe)(2). Plasma and urinary protein, hemoglobin and hematocrit levels and histological parameters were also ameliorated in mice exposed to HgCl(2)+(ClPhSe)(2). In addition, the hepatic damage in mice exposed to HgCl(2)+(PhSe)(2) was reduced in animals exposed to (ClPhSe)(2). To sum up, the introduction of a functional group (chloro) in the aromatic ring of diaryl diselenide reduced the toxicity of this compound in liver and kidney of mice exposed to HgCl(2). SN - 1872-7077 UR - https://www.unboundmedicine.com/medline/citation/22981437/Effects_of_44'_dichloro_diphenyl_diselenide__ClPhSe_2_on_toxicity_induced_by_mercuric_chloride_in_mice:_a_comparative_study_with_diphenyl_diselenide__PhSe_2_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1382-6689(12)00109-3 DB - PRIME DP - Unbound Medicine ER -