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Quantification of red blood cell deformation at high-hematocrit blood flow in microvessels.
J Biomech 2012; 45(15):2684-9JB

Abstract

The deformation of red blood cells in microvessels was investigated numerically for various vessel diameters, hematocrits, and shear rates. We simulated blood flow in circular channels with diameters ranging from 9 to 50 μm, hematocrits from 20% to 45%, and shear rates from 20 to 150 s(-1) using a particle-based model with parallel computing. The apparent viscosity predicted by the simulation was in good agreement with previous experimental results. We quantified the deformation of red blood cells as a function of radial position. The numerical results demonstrated that because of the shape transition in response to local shear stress and the wall effect, the radial variation of red blood cell deformation in relatively large microvessels could be classified into three different regions: near-center, middle, and near-wall regions. Effects of the local shear stress and wall varied with vessel diameter, hematocrit, and shear rate.

Authors+Show Affiliations

Department of Biomedical Engineering, Tohoku University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22981440

Citation

Alizadehrad, Davod, et al. "Quantification of Red Blood Cell Deformation at High-hematocrit Blood Flow in Microvessels." Journal of Biomechanics, vol. 45, no. 15, 2012, pp. 2684-9.
Alizadehrad D, Imai Y, Nakaaki K, et al. Quantification of red blood cell deformation at high-hematocrit blood flow in microvessels. J Biomech. 2012;45(15):2684-9.
Alizadehrad, D., Imai, Y., Nakaaki, K., Ishikawa, T., & Yamaguchi, T. (2012). Quantification of red blood cell deformation at high-hematocrit blood flow in microvessels. Journal of Biomechanics, 45(15), pp. 2684-9. doi:10.1016/j.jbiomech.2012.08.026.
Alizadehrad D, et al. Quantification of Red Blood Cell Deformation at High-hematocrit Blood Flow in Microvessels. J Biomech. 2012 Oct 11;45(15):2684-9. PubMed PMID: 22981440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of red blood cell deformation at high-hematocrit blood flow in microvessels. AU - Alizadehrad,Davod, AU - Imai,Yohsuke, AU - Nakaaki,Keita, AU - Ishikawa,Takuji, AU - Yamaguchi,Takami, Y1 - 2012/09/13/ PY - 2012/01/04/received PY - 2012/07/04/revised PY - 2012/08/21/accepted PY - 2012/9/18/entrez PY - 2012/9/18/pubmed PY - 2013/2/13/medline SP - 2684 EP - 9 JF - Journal of biomechanics JO - J Biomech VL - 45 IS - 15 N2 - The deformation of red blood cells in microvessels was investigated numerically for various vessel diameters, hematocrits, and shear rates. We simulated blood flow in circular channels with diameters ranging from 9 to 50 μm, hematocrits from 20% to 45%, and shear rates from 20 to 150 s(-1) using a particle-based model with parallel computing. The apparent viscosity predicted by the simulation was in good agreement with previous experimental results. We quantified the deformation of red blood cells as a function of radial position. The numerical results demonstrated that because of the shape transition in response to local shear stress and the wall effect, the radial variation of red blood cell deformation in relatively large microvessels could be classified into three different regions: near-center, middle, and near-wall regions. Effects of the local shear stress and wall varied with vessel diameter, hematocrit, and shear rate. SN - 1873-2380 UR - https://www.unboundmedicine.com/medline/citation/22981440/Quantification_of_red_blood_cell_deformation_at_high_hematocrit_blood_flow_in_microvessels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9290(12)00487-3 DB - PRIME DP - Unbound Medicine ER -