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Association between apolipoprotein E gene polymorphism and the risk of multiple sclerosis: a meta-analysis of 6977 subjects.
Gene. 2012 Dec 10; 511(1):12-7.GENE

Abstract

Epidemiological studies have evaluated the association between apolipoprotein E (ApoE) gene polymorphism and multiple sclerosis (MS) risk. However, the results remain conflicting. Therefore, in order to derive a more precise association of ApoE gene polymorphism with MS risk, we performed this meta-analysis. Systematic searches of electronic databases PubMed, Embase and Web of Science, as well as hand searching of the references of identified articles were performed. Twenty studies were identified, covering a total of 4080 MS cases and 2897 controls. The results showed evidence for significant association between ApoE ε2 mutation and MS risk (for ε2/ε4 versus ε3/ε3: OR=1.74, 95% CI=1.12-2.71, p=0.01; for ε2 allele versus ε3 allele: OR=1.16, 95% CI=1.01-1.35, p=0.04). In the subgroup analysis by ethnicity, the similar results were obtained among Europeans (for ε2/ε4 versus ε3/ε3: OR=1.81, 95% CI=1.14-2.87, p=0.01; for ε2 allele versus ε3 allele: OR=1.19, 95% CI=1.02-1.38, p=0.03). After excluding the outlier studies by observing Galbraith plot, marginal association was found between ApoE ε3/ε4 genotype and the protective factor for MS (for ε3/ε4 versus ε3/ε3: OR=0.86, 95% CI=0.75-0.99, p=0.04). In summary, the present meta-analysis provides evidence that ApoE ε2 mutation is associated with MS risk. In addition, ApoE ε3/ε4 genotype appears to be a protective factor for MS.

Authors+Show Affiliations

Department of Neurology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing 400042, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22982410

Citation

Yin, Yan-Wei, et al. "Association Between Apolipoprotein E Gene Polymorphism and the Risk of Multiple Sclerosis: a Meta-analysis of 6977 Subjects." Gene, vol. 511, no. 1, 2012, pp. 12-7.
Yin YW, Zhang YD, Wang JZ, et al. Association between apolipoprotein E gene polymorphism and the risk of multiple sclerosis: a meta-analysis of 6977 subjects. Gene. 2012;511(1):12-7.
Yin, Y. W., Zhang, Y. D., Wang, J. Z., Li, B. H., Yang, Q. W., Fang, C. Q., Gao, C. Y., Li, J. C., & Zhang, L. L. (2012). Association between apolipoprotein E gene polymorphism and the risk of multiple sclerosis: a meta-analysis of 6977 subjects. Gene, 511(1), 12-7. https://doi.org/10.1016/j.gene.2012.09.010
Yin YW, et al. Association Between Apolipoprotein E Gene Polymorphism and the Risk of Multiple Sclerosis: a Meta-analysis of 6977 Subjects. Gene. 2012 Dec 10;511(1):12-7. PubMed PMID: 22982410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between apolipoprotein E gene polymorphism and the risk of multiple sclerosis: a meta-analysis of 6977 subjects. AU - Yin,Yan-Wei, AU - Zhang,Yun-Dong, AU - Wang,Jing-Zhou, AU - Li,Bing-Hu, AU - Yang,Qing-Wu, AU - Fang,Chuan-Qin, AU - Gao,Chang-Yue, AU - Li,Jing-Cheng, AU - Zhang,Li-Li, Y1 - 2012/09/13/ PY - 2012/07/09/received PY - 2012/09/05/revised PY - 2012/09/06/accepted PY - 2012/9/18/entrez PY - 2012/9/18/pubmed PY - 2013/1/11/medline SP - 12 EP - 7 JF - Gene JO - Gene VL - 511 IS - 1 N2 - Epidemiological studies have evaluated the association between apolipoprotein E (ApoE) gene polymorphism and multiple sclerosis (MS) risk. However, the results remain conflicting. Therefore, in order to derive a more precise association of ApoE gene polymorphism with MS risk, we performed this meta-analysis. Systematic searches of electronic databases PubMed, Embase and Web of Science, as well as hand searching of the references of identified articles were performed. Twenty studies were identified, covering a total of 4080 MS cases and 2897 controls. The results showed evidence for significant association between ApoE ε2 mutation and MS risk (for ε2/ε4 versus ε3/ε3: OR=1.74, 95% CI=1.12-2.71, p=0.01; for ε2 allele versus ε3 allele: OR=1.16, 95% CI=1.01-1.35, p=0.04). In the subgroup analysis by ethnicity, the similar results were obtained among Europeans (for ε2/ε4 versus ε3/ε3: OR=1.81, 95% CI=1.14-2.87, p=0.01; for ε2 allele versus ε3 allele: OR=1.19, 95% CI=1.02-1.38, p=0.03). After excluding the outlier studies by observing Galbraith plot, marginal association was found between ApoE ε3/ε4 genotype and the protective factor for MS (for ε3/ε4 versus ε3/ε3: OR=0.86, 95% CI=0.75-0.99, p=0.04). In summary, the present meta-analysis provides evidence that ApoE ε2 mutation is associated with MS risk. In addition, ApoE ε3/ε4 genotype appears to be a protective factor for MS. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/22982410/Association_between_apolipoprotein_E_gene_polymorphism_and_the_risk_of_multiple_sclerosis:_a_meta_analysis_of_6977_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(12)01091-8 DB - PRIME DP - Unbound Medicine ER -