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The effect of intrathecal gabapentin on neuropathic pain is independent of the integrity of the dorsolateral funiculus in rats.
Life Sci. 2012 Oct 29; 91(17-18):837-42.LS

Abstract

AIM

This study evaluates the contribution of inhibitory pain pathways that descend to the spinal cord through the dorsolateral funiculus (DLF) on the effect of intrathecal gabapentin against spinal nerve ligation (SNL)-induced behavioral hypersensitivity to mechanical stimulation in rats.

MAIN METHOD

Rats were submitted to a sham or complete ligation of the right L5 and L6 spinal nerves and a sham or complete DLF lesion. Next, the changes induced by intrathecal administration of gabapentin on the paw withdrawal threshold of rats to mechanical stimulation were evaluated electronically.

KEY FINDINGS

Intrathecal gabapentin (200μg/5μl) that was injected 2 or 7days after surgery fully inhibited the SNL-induced behavioral hypersensitivity to mechanical stimulation in sham DLF-lesioned rats; gabapentin was effective against the SNL-induced behavioral hypersensitivity to mechanical stimulation also in DLF-lesioned rats.

SIGNIFICANCE

The effect of intrathecally administered gabapentin against SNL-induced behavioral hypersensitivity to mechanical stimulation in rats does not depend on the activation of nerve fibers that descend to the spinal cord via the DLF.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo 14049–900, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22982419

Citation

Dias, Quintino Moura, et al. "The Effect of Intrathecal Gabapentin On Neuropathic Pain Is Independent of the Integrity of the Dorsolateral Funiculus in Rats." Life Sciences, vol. 91, no. 17-18, 2012, pp. 837-42.
Dias QM, Silveira JW, Reis GM, et al. The effect of intrathecal gabapentin on neuropathic pain is independent of the integrity of the dorsolateral funiculus in rats. Life Sci. 2012;91(17-18):837-42.
Dias, Q. M., Silveira, J. W., Reis, G. M., Costa, K. A., Rossaneis, A. C., Fais, R. S., & Prado, W. A. (2012). The effect of intrathecal gabapentin on neuropathic pain is independent of the integrity of the dorsolateral funiculus in rats. Life Sciences, 91(17-18), 837-42. https://doi.org/10.1016/j.lfs.2012.08.032
Dias QM, et al. The Effect of Intrathecal Gabapentin On Neuropathic Pain Is Independent of the Integrity of the Dorsolateral Funiculus in Rats. Life Sci. 2012 Oct 29;91(17-18):837-42. PubMed PMID: 22982419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of intrathecal gabapentin on neuropathic pain is independent of the integrity of the dorsolateral funiculus in rats. AU - Dias,Quintino Moura, AU - Silveira,João Walter Souza, AU - Reis,Gláucia Melo, AU - Costa,Karina Abdo, AU - Rossaneis,Ana Carolina, AU - Fais,Rafael Sobrano, AU - Prado,Wiliam Alves, Y1 - 2012/09/12/ PY - 2012/04/04/received PY - 2012/08/07/revised PY - 2012/08/27/accepted PY - 2012/9/18/entrez PY - 2012/9/18/pubmed PY - 2013/1/8/medline SP - 837 EP - 42 JF - Life sciences JO - Life Sci VL - 91 IS - 17-18 N2 - AIM: This study evaluates the contribution of inhibitory pain pathways that descend to the spinal cord through the dorsolateral funiculus (DLF) on the effect of intrathecal gabapentin against spinal nerve ligation (SNL)-induced behavioral hypersensitivity to mechanical stimulation in rats. MAIN METHOD: Rats were submitted to a sham or complete ligation of the right L5 and L6 spinal nerves and a sham or complete DLF lesion. Next, the changes induced by intrathecal administration of gabapentin on the paw withdrawal threshold of rats to mechanical stimulation were evaluated electronically. KEY FINDINGS: Intrathecal gabapentin (200μg/5μl) that was injected 2 or 7days after surgery fully inhibited the SNL-induced behavioral hypersensitivity to mechanical stimulation in sham DLF-lesioned rats; gabapentin was effective against the SNL-induced behavioral hypersensitivity to mechanical stimulation also in DLF-lesioned rats. SIGNIFICANCE: The effect of intrathecally administered gabapentin against SNL-induced behavioral hypersensitivity to mechanical stimulation in rats does not depend on the activation of nerve fibers that descend to the spinal cord via the DLF. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/22982419/The_effect_of_intrathecal_gabapentin_on_neuropathic_pain_is_independent_of_the_integrity_of_the_dorsolateral_funiculus_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(12)00482-1 DB - PRIME DP - Unbound Medicine ER -