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Serum retinol-binding protein 4 is independently associated with pediatric NAFLD and fasting triglyceride level.
J Pediatr Gastroenterol Nutr. 2013 Feb; 56(2):145-50.JP

Abstract

OBJECTIVES

Nonalcoholic fatty liver disease (NAFLD) is identified as a major liver disease in children. The present study aimed to identify the prevalence and predictors of pediatric NAFLD and the correlation between serum retinol-binding protein 4 (RBP4) levels and metabolic characteristics in children.

METHODS

A total of 748 schoolchildren, ages 6 to 12 years, were enrolled in 2009. The body weight and height were measured in the morning before intake. Laboratory tests included overnight fasting serum lipids, insulin, liver enzymes, and RBP4 levels. Hepatic steatosis was determined by ultrasound in 219 volunteers.

RESULTS

The rates of NAFLD were 3% in the normal-weight, 25% in the overweight, and 76% in the obese children. Twenty (22%) of obese children had abnormal alanine aminotransferase (ALT) levels. In children with NAFLD, younger age and higher body mass index (BMI), insulin/homeostasis model of assessment, and male sex rate were associated with abnormal liver function. Stepwise increments in BMI, insulin, homeostasis model of assessment, and ALT were found in children with normal livers to simple steatosis, and to steatosis with abnormal ALT. Multiple logistic regression analysis confirmed that serum RBP4 levels (P = 0.048), ALT (P = 0.048), and BMI (P < 0.001) were independently predictors of pediatric NAFLD. Moreover, multiple linear regression analysis revealed that only serum triglycerides levels were positively related to RBP4 levels (P < 0.001).

CONCLUSIONS

Higher RBP4 and ALT levels as well as BMI are independently associated with pediatric NAFLD in Taiwan. In addition, an increment in RBP4 levels was positively correlated to hypertriglyceridemia in children.

Authors+Show Affiliations

Department of Pediatrics, Kuo General Hospital, Tainan, Taiwan.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22983378

Citation

Huang, Shu-Ching, and Yao-Jong Yang. "Serum Retinol-binding Protein 4 Is Independently Associated With Pediatric NAFLD and Fasting Triglyceride Level." Journal of Pediatric Gastroenterology and Nutrition, vol. 56, no. 2, 2013, pp. 145-50.
Huang SC, Yang YJ. Serum retinol-binding protein 4 is independently associated with pediatric NAFLD and fasting triglyceride level. J Pediatr Gastroenterol Nutr. 2013;56(2):145-50.
Huang, S. C., & Yang, Y. J. (2013). Serum retinol-binding protein 4 is independently associated with pediatric NAFLD and fasting triglyceride level. Journal of Pediatric Gastroenterology and Nutrition, 56(2), 145-50. https://doi.org/10.1097/MPG.0b013e3182722aee
Huang SC, Yang YJ. Serum Retinol-binding Protein 4 Is Independently Associated With Pediatric NAFLD and Fasting Triglyceride Level. J Pediatr Gastroenterol Nutr. 2013;56(2):145-50. PubMed PMID: 22983378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum retinol-binding protein 4 is independently associated with pediatric NAFLD and fasting triglyceride level. AU - Huang,Shu-Ching, AU - Yang,Yao-Jong, PY - 2012/9/18/entrez PY - 2012/9/18/pubmed PY - 2013/7/3/medline SP - 145 EP - 50 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 56 IS - 2 N2 - OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) is identified as a major liver disease in children. The present study aimed to identify the prevalence and predictors of pediatric NAFLD and the correlation between serum retinol-binding protein 4 (RBP4) levels and metabolic characteristics in children. METHODS: A total of 748 schoolchildren, ages 6 to 12 years, were enrolled in 2009. The body weight and height were measured in the morning before intake. Laboratory tests included overnight fasting serum lipids, insulin, liver enzymes, and RBP4 levels. Hepatic steatosis was determined by ultrasound in 219 volunteers. RESULTS: The rates of NAFLD were 3% in the normal-weight, 25% in the overweight, and 76% in the obese children. Twenty (22%) of obese children had abnormal alanine aminotransferase (ALT) levels. In children with NAFLD, younger age and higher body mass index (BMI), insulin/homeostasis model of assessment, and male sex rate were associated with abnormal liver function. Stepwise increments in BMI, insulin, homeostasis model of assessment, and ALT were found in children with normal livers to simple steatosis, and to steatosis with abnormal ALT. Multiple logistic regression analysis confirmed that serum RBP4 levels (P = 0.048), ALT (P = 0.048), and BMI (P < 0.001) were independently predictors of pediatric NAFLD. Moreover, multiple linear regression analysis revealed that only serum triglycerides levels were positively related to RBP4 levels (P < 0.001). CONCLUSIONS: Higher RBP4 and ALT levels as well as BMI are independently associated with pediatric NAFLD in Taiwan. In addition, an increment in RBP4 levels was positively correlated to hypertriglyceridemia in children. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/22983378/Serum_retinol_binding_protein_4_is_independently_associated_with_pediatric_NAFLD_and_fasting_triglyceride_level_ L2 - https://doi.org/10.1097/MPG.0b013e3182722aee DB - PRIME DP - Unbound Medicine ER -