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Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic review and meta-analysis.

Abstract

BACKGROUND

Prospective cohort studies in relation to the associations between n-3 polyunsaturated fatty acids (PUFA) and risk of type 2 diabetes (T2D) were inconsistent. Differences in tissue n-3 PUFA compositions in subjects with and without T2D were also inconsistent in both cohort and case-control studies. We conducted a systematic review and meta-analysis of prospective cohort studies to examine the associations of fish and n-3 PUFA intake with T2D risk. The differences in tissue n-3 PUFA compositions in subjects with and without T2D were investigated based on cohort and case-control studies.

METHODS AND FINDINGS

PubMed, Embase, Cochrane library, China National Knowledge Infrastructure (CNKI) and Chinese VIP database up to January 2012 was used to identify relevant studies, and reference lists from retrieved studies were reviewed. Two authors independently extracted the data. Random-effects models were used to pool the summary relative risk (RR). Twenty-four studies including 24,509 T2D patients and 545,275 participants were identified. For cohort studies, the summary RR of T2D for the highest vs lowest categories of total fish, marine n-3 PUFA and alpha-linolenic acid intake was 1.07 (95% CI: 0.91, 1.25), 1.07 (95% CI: 0.95, 1.20) and 0.93 (95% CI: 0.81, 1.07), respectively. Subgroup analyses indicated that summary RR (highest vs lowest category) of T2D for fish and marine n-3 PUFA intake was 0.89 (95% CI: 0.81, 0.98) and 0.87 (95% CI: 0.79, 0.96) for Asian populations, and 1.20 (95% CI: 1.01, 1.44) and 1.16 (95% CI: 1.04, 1.28) for Western populations. Asian subjects with T2D had significantly lower tissue compositions of C22:6n-3 (SMD: -1.43; 95% CI: -1.75, -1.12) and total n-3 PUFA (SMD: -1.41; 95% CI: -2.23, -0.59) compared with those without T2D.

CONCLUSION

This systematic review and meta-analysis provides evidence that marine n-3 PUFA have beneficial effects on the prevention of T2D in Asian populations.

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  • Authors+Show Affiliations

    ,

    Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.

    , , ,

    Source

    PloS one 7:9 2012 pg e44525

    MeSH

    Adult
    Aged
    Animals
    Asian Continental Ancestry Group
    Case-Control Studies
    Cohort Studies
    Diabetes Mellitus, Type 2
    Diet
    Fatty Acids, Omega-3
    Female
    Fish Oils
    Humans
    Male
    Middle Aged
    Prospective Studies
    Risk

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    22984522

    Citation

    Zheng, Ju-Sheng, et al. "Marine N-3 Polyunsaturated Fatty Acids Are Inversely Associated With Risk of Type 2 Diabetes in Asians: a Systematic Review and Meta-analysis." PloS One, vol. 7, no. 9, 2012, pp. e44525.
    Zheng JS, Huang T, Yang J, et al. Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic review and meta-analysis. PLoS ONE. 2012;7(9):e44525.
    Zheng, J. S., Huang, T., Yang, J., Fu, Y. Q., & Li, D. (2012). Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic review and meta-analysis. PloS One, 7(9), pp. e44525. doi:10.1371/journal.pone.0044525.
    Zheng JS, et al. Marine N-3 Polyunsaturated Fatty Acids Are Inversely Associated With Risk of Type 2 Diabetes in Asians: a Systematic Review and Meta-analysis. PLoS ONE. 2012;7(9):e44525. PubMed PMID: 22984522.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic review and meta-analysis. AU - Zheng,Ju-Sheng, AU - Huang,Tao, AU - Yang,Jing, AU - Fu,Yuan-Qing, AU - Li,Duo, Y1 - 2012/09/11/ PY - 2012/04/11/received PY - 2012/08/03/accepted PY - 2012/9/18/entrez PY - 2012/9/18/pubmed PY - 2013/3/13/medline SP - e44525 EP - e44525 JF - PloS one JO - PLoS ONE VL - 7 IS - 9 N2 - BACKGROUND: Prospective cohort studies in relation to the associations between n-3 polyunsaturated fatty acids (PUFA) and risk of type 2 diabetes (T2D) were inconsistent. Differences in tissue n-3 PUFA compositions in subjects with and without T2D were also inconsistent in both cohort and case-control studies. We conducted a systematic review and meta-analysis of prospective cohort studies to examine the associations of fish and n-3 PUFA intake with T2D risk. The differences in tissue n-3 PUFA compositions in subjects with and without T2D were investigated based on cohort and case-control studies. METHODS AND FINDINGS: PubMed, Embase, Cochrane library, China National Knowledge Infrastructure (CNKI) and Chinese VIP database up to January 2012 was used to identify relevant studies, and reference lists from retrieved studies were reviewed. Two authors independently extracted the data. Random-effects models were used to pool the summary relative risk (RR). Twenty-four studies including 24,509 T2D patients and 545,275 participants were identified. For cohort studies, the summary RR of T2D for the highest vs lowest categories of total fish, marine n-3 PUFA and alpha-linolenic acid intake was 1.07 (95% CI: 0.91, 1.25), 1.07 (95% CI: 0.95, 1.20) and 0.93 (95% CI: 0.81, 1.07), respectively. Subgroup analyses indicated that summary RR (highest vs lowest category) of T2D for fish and marine n-3 PUFA intake was 0.89 (95% CI: 0.81, 0.98) and 0.87 (95% CI: 0.79, 0.96) for Asian populations, and 1.20 (95% CI: 1.01, 1.44) and 1.16 (95% CI: 1.04, 1.28) for Western populations. Asian subjects with T2D had significantly lower tissue compositions of C22:6n-3 (SMD: -1.43; 95% CI: -1.75, -1.12) and total n-3 PUFA (SMD: -1.41; 95% CI: -2.23, -0.59) compared with those without T2D. CONCLUSION: This systematic review and meta-analysis provides evidence that marine n-3 PUFA have beneficial effects on the prevention of T2D in Asian populations. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22984522/Marine_N_3_polyunsaturated_fatty_acids_are_inversely_associated_with_risk_of_type_2_diabetes_in_Asians:_a_systematic_review_and_meta_analysis_ L2 - http://dx.plos.org/10.1371/journal.pone.0044525 DB - PRIME DP - Unbound Medicine ER -