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Effects of dietary supplementation of inosine monophosphate on growth performance, innate immunity and disease resistance of olive flounder (Paralichthys olivaceus).
Fish Shellfish Immunol. 2012 Oct; 33(4):1050-4.FS

Abstract

This study was investigated to examine the effects of dietary inosine monophosphate (IMP) supplementation on growth performance, feed utilization, innate immunity, hematological parameters and disease resistance of juvenile olive flounder. Five experimental diets were formulated to contain IMP at levels of 0, 0.1, 0.2, 0.4 and 1.0%. All diets were maintained isonitrogenous (48% crude protein) and isocaloric (20.7 MJ/kg diet). Triplicate groups of olive flounder (initial body weight, 7.5 ± 0.02 g) were fed one of the experimental diets to apparent satiation (twice a day) for 14 weeks. Final body weight of fish fed 0.1-0.2% IMP were significantly higher than that of fish fed the 1.0% IMP. Groups of fish fed 0.2 or 0.4% IMP diet had significantly higher myeloperoxidase and lysozyme activities than fish fed the control diet. However, nitro-blue-tetrazolium and superoxide dismutase activities were not significantly different among all treatments. In the challenge test against Streptococcus iniae, cumulative mortality of fish fed IMP supplemented diets was significantly lower (15%, 4%, 4% and 9% for 0.1%, 0.2%, 0.4% and 1.0% IMP, respectively) than that of fish fed the control group (87%). The results suggest that IMP supplementation of 0.46-1.84 g into a kg of fish meal based diet (0.1-0.4% IMP product) can enhance innate immunity and disease resistance of olive flounder.

Authors+Show Affiliations

Department of Marine Life Sciences, Jeju National University, 66 Jejudaehakro, Jeju 690-756, South Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22986588

Citation

Song, Jin-Woo, et al. "Effects of Dietary Supplementation of Inosine Monophosphate On Growth Performance, Innate Immunity and Disease Resistance of Olive Flounder (Paralichthys Olivaceus)." Fish & Shellfish Immunology, vol. 33, no. 4, 2012, pp. 1050-4.
Song JW, Lim SJ, Lee KJ. Effects of dietary supplementation of inosine monophosphate on growth performance, innate immunity and disease resistance of olive flounder (Paralichthys olivaceus). Fish Shellfish Immunol. 2012;33(4):1050-4.
Song, J. W., Lim, S. J., & Lee, K. J. (2012). Effects of dietary supplementation of inosine monophosphate on growth performance, innate immunity and disease resistance of olive flounder (Paralichthys olivaceus). Fish & Shellfish Immunology, 33(4), 1050-4. https://doi.org/10.1016/j.fsi.2012.07.011
Song JW, Lim SJ, Lee KJ. Effects of Dietary Supplementation of Inosine Monophosphate On Growth Performance, Innate Immunity and Disease Resistance of Olive Flounder (Paralichthys Olivaceus). Fish Shellfish Immunol. 2012;33(4):1050-4. PubMed PMID: 22986588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dietary supplementation of inosine monophosphate on growth performance, innate immunity and disease resistance of olive flounder (Paralichthys olivaceus). AU - Song,Jin-Woo, AU - Lim,Se-Jin, AU - Lee,Kyeong-Jun, Y1 - 2012/08/07/ PY - 2012/03/05/received PY - 2012/07/04/revised PY - 2012/07/25/accepted PY - 2012/9/19/entrez PY - 2012/9/19/pubmed PY - 2013/3/5/medline SP - 1050 EP - 4 JF - Fish & shellfish immunology JO - Fish Shellfish Immunol VL - 33 IS - 4 N2 - This study was investigated to examine the effects of dietary inosine monophosphate (IMP) supplementation on growth performance, feed utilization, innate immunity, hematological parameters and disease resistance of juvenile olive flounder. Five experimental diets were formulated to contain IMP at levels of 0, 0.1, 0.2, 0.4 and 1.0%. All diets were maintained isonitrogenous (48% crude protein) and isocaloric (20.7 MJ/kg diet). Triplicate groups of olive flounder (initial body weight, 7.5 ± 0.02 g) were fed one of the experimental diets to apparent satiation (twice a day) for 14 weeks. Final body weight of fish fed 0.1-0.2% IMP were significantly higher than that of fish fed the 1.0% IMP. Groups of fish fed 0.2 or 0.4% IMP diet had significantly higher myeloperoxidase and lysozyme activities than fish fed the control diet. However, nitro-blue-tetrazolium and superoxide dismutase activities were not significantly different among all treatments. In the challenge test against Streptococcus iniae, cumulative mortality of fish fed IMP supplemented diets was significantly lower (15%, 4%, 4% and 9% for 0.1%, 0.2%, 0.4% and 1.0% IMP, respectively) than that of fish fed the control group (87%). The results suggest that IMP supplementation of 0.46-1.84 g into a kg of fish meal based diet (0.1-0.4% IMP product) can enhance innate immunity and disease resistance of olive flounder. SN - 1095-9947 UR - https://www.unboundmedicine.com/medline/citation/22986588/Effects_of_dietary_supplementation_of_inosine_monophosphate_on_growth_performance_innate_immunity_and_disease_resistance_of_olive_flounder__Paralichthys_olivaceus__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1050-4648(12)00274-4 DB - PRIME DP - Unbound Medicine ER -