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A modest proposal for a longitudinal study of dementia prevention (with apologies to Jonathan Swift, 1729).
J Alzheimers Dis 2013; 33(2):313-5JA

Abstract

Many studies have documented the role of risk and protective factors for late life dementing illnesses, particularly Alzheimer's disease. A "Systematic Review" from the US Agency for Healthcare Research and Quality and the National Institute on Aging concluded that because the overall quality of evidence was low, recommendations for public health could not be made. In order to gain evidence for the efficacy of lifestyle interventions, we propose a "Modest Proposal" to study 10,000 subjects over 40 years randomly assigned to groups of low or high saturated fat in the diet, head injury, and high or low levels of mental activity, physical activity, or inactivity as well as smoking or non-smoking. This proposed study cannot be accomplished. The "Modest Proposal" illustrates that the absence of definitive evidence should not restrict physicians from making reasonable recommendations based on the evidence that is available.

Authors+Show Affiliations

Department of Neurology, University of Louisville School of Medicine, Louisville, KY 40207, USA. robert.friedland@louisville.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22986779

Citation

Friedland, Robert P., and Shivani Nandi. "A Modest Proposal for a Longitudinal Study of Dementia Prevention (with Apologies to Jonathan Swift, 1729)." Journal of Alzheimer's Disease : JAD, vol. 33, no. 2, 2013, pp. 313-5.
Friedland RP, Nandi S. A modest proposal for a longitudinal study of dementia prevention (with apologies to Jonathan Swift, 1729). J Alzheimers Dis. 2013;33(2):313-5.
Friedland, R. P., & Nandi, S. (2013). A modest proposal for a longitudinal study of dementia prevention (with apologies to Jonathan Swift, 1729). Journal of Alzheimer's Disease : JAD, 33(2), pp. 313-5. doi:10.3233/JAD-2012-121459.
Friedland RP, Nandi S. A Modest Proposal for a Longitudinal Study of Dementia Prevention (with Apologies to Jonathan Swift, 1729). J Alzheimers Dis. 2013;33(2):313-5. PubMed PMID: 22986779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A modest proposal for a longitudinal study of dementia prevention (with apologies to Jonathan Swift, 1729). AU - Friedland,Robert P, AU - Nandi,Shivani, PY - 2012/9/19/entrez PY - 2012/9/19/pubmed PY - 2013/5/29/medline SP - 313 EP - 5 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 33 IS - 2 N2 - Many studies have documented the role of risk and protective factors for late life dementing illnesses, particularly Alzheimer's disease. A "Systematic Review" from the US Agency for Healthcare Research and Quality and the National Institute on Aging concluded that because the overall quality of evidence was low, recommendations for public health could not be made. In order to gain evidence for the efficacy of lifestyle interventions, we propose a "Modest Proposal" to study 10,000 subjects over 40 years randomly assigned to groups of low or high saturated fat in the diet, head injury, and high or low levels of mental activity, physical activity, or inactivity as well as smoking or non-smoking. This proposed study cannot be accomplished. The "Modest Proposal" illustrates that the absence of definitive evidence should not restrict physicians from making reasonable recommendations based on the evidence that is available. SN - 1875-8908 UR - http://www.unboundmedicine.com/medline/citation/22986779/A_modest_proposal_for_a_longitudinal_study_of_dementia_prevention__with_apologies_to_Jonathan_Swift_1729__ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2012-121459 DB - PRIME DP - Unbound Medicine ER -