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A modest proposal for a longitudinal study of dementia prevention (with apologies to Jonathan Swift, 1729).

Abstract

Many studies have documented the role of risk and protective factors for late life dementing illnesses, particularly Alzheimer's disease. A "Systematic Review" from the US Agency for Healthcare Research and Quality and the National Institute on Aging concluded that because the overall quality of evidence was low, recommendations for public health could not be made. In order to gain evidence for the efficacy of lifestyle interventions, we propose a "Modest Proposal" to study 10,000 subjects over 40 years randomly assigned to groups of low or high saturated fat in the diet, head injury, and high or low levels of mental activity, physical activity, or inactivity as well as smoking or non-smoking. This proposed study cannot be accomplished. The "Modest Proposal" illustrates that the absence of definitive evidence should not restrict physicians from making reasonable recommendations based on the evidence that is available.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Neurology, University of Louisville School of Medicine, Louisville, KY 40207, USA. robert.friedland@louisville.edu

    Source

    MeSH

    Adult
    Aged
    Aging
    Alzheimer Disease
    Dementia
    Humans
    Life Style
    Longitudinal Studies
    Middle Aged
    Randomized Controlled Trials as Topic
    Risk Factors
    Risk Reduction Behavior

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    22986779

    Citation

    Friedland, Robert P., and Shivani Nandi. "A Modest Proposal for a Longitudinal Study of Dementia Prevention (with Apologies to Jonathan Swift, 1729)." Journal of Alzheimer's Disease : JAD, vol. 33, no. 2, 2013, pp. 313-5.
    Friedland RP, Nandi S. A modest proposal for a longitudinal study of dementia prevention (with apologies to Jonathan Swift, 1729). J Alzheimers Dis. 2013;33(2):313-5.
    Friedland, R. P., & Nandi, S. (2013). A modest proposal for a longitudinal study of dementia prevention (with apologies to Jonathan Swift, 1729). Journal of Alzheimer's Disease : JAD, 33(2), pp. 313-5. doi:10.3233/JAD-2012-121459.
    Friedland RP, Nandi S. A Modest Proposal for a Longitudinal Study of Dementia Prevention (with Apologies to Jonathan Swift, 1729). J Alzheimers Dis. 2013;33(2):313-5. PubMed PMID: 22986779.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A modest proposal for a longitudinal study of dementia prevention (with apologies to Jonathan Swift, 1729). AU - Friedland,Robert P, AU - Nandi,Shivani, PY - 2012/9/19/entrez PY - 2012/9/19/pubmed PY - 2013/5/29/medline SP - 313 EP - 5 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 33 IS - 2 N2 - Many studies have documented the role of risk and protective factors for late life dementing illnesses, particularly Alzheimer's disease. A "Systematic Review" from the US Agency for Healthcare Research and Quality and the National Institute on Aging concluded that because the overall quality of evidence was low, recommendations for public health could not be made. In order to gain evidence for the efficacy of lifestyle interventions, we propose a "Modest Proposal" to study 10,000 subjects over 40 years randomly assigned to groups of low or high saturated fat in the diet, head injury, and high or low levels of mental activity, physical activity, or inactivity as well as smoking or non-smoking. This proposed study cannot be accomplished. The "Modest Proposal" illustrates that the absence of definitive evidence should not restrict physicians from making reasonable recommendations based on the evidence that is available. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/22986779/A_modest_proposal_for_a_longitudinal_study_of_dementia_prevention__with_apologies_to_Jonathan_Swift_1729__ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-2012-121459 DB - PRIME DP - Unbound Medicine ER -