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Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: a multicenter retrospective analysis.
Surgery 2013; 153(3):357-64S

Abstract

BACKGROUND

Chronic pancreatitis is suggested to be one of the risk factors for the development of pancreatic cancer. The aim of this study was to confirm the high incidence of pancreatic cancer in patients with chronic pancreatitis in Japan and to determine the factors associated with the risk for pancreatic cancer in patients with chronic pancreatitis.

METHODS

The working group of the Research Committee of Intractable Disease supported by the Ministry of Health, Labour and Welfare of Japan carried out a nationwide survey to investigate the relationship between chronic pancreatitis and pancreatic cancer. This retrospective study included patients diagnosed with chronic pancreatitis who had had at least 2 years of follow-up. They were contacted through 22 Japanese referral centers experienced in the management of chronic pancreatitis.

RESULTS

The standardized incidence ratio (95 CI) of pancreatic cancer was 11.8 (7.1-18.4). The incidence of pancreatic cancer was significantly lower in patients who had received surgery for chronic pancreatitis than in those who had not undergone surgery (hazard ratio estimated by Cox regression 0.11; 95% CI, 0.0014-0.80; P = .03). Patients who continued to drink alcohol after diagnosis of chronic pancreatitis showed a significantly higher incidence of pancreatic cancer than those who stopped drinking after diagnosis of chronic pancreatitis (hazard ratio, 5.07; 95% CI, 1.13-22.73; P = .03).

CONCLUSION

This study confirmed that chronic pancreatitis is an important risk factor for the development of pancreatic cancer in Japan. Patients who underwent surgery for the treatment of chronic pancreatitis had significantly lower incidences of pancreatic cancer. Surgery for chronic pancreatitis may inhibit the development of pancreatic cancer in patients with chronic pancreatitis.

Authors+Show Affiliations

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22989892

Citation

Ueda, Junji, et al. "Surgery for Chronic Pancreatitis Decreases the Risk for Pancreatic Cancer: a Multicenter Retrospective Analysis." Surgery, vol. 153, no. 3, 2013, pp. 357-64.
Ueda J, Tanaka M, Ohtsuka T, et al. Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: a multicenter retrospective analysis. Surgery. 2013;153(3):357-64.
Ueda, J., Tanaka, M., Ohtsuka, T., Tokunaga, S., & Shimosegawa, T. (2013). Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: a multicenter retrospective analysis. Surgery, 153(3), pp. 357-64. doi:10.1016/j.surg.2012.08.005.
Ueda J, et al. Surgery for Chronic Pancreatitis Decreases the Risk for Pancreatic Cancer: a Multicenter Retrospective Analysis. Surgery. 2013;153(3):357-64. PubMed PMID: 22989892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgery for chronic pancreatitis decreases the risk for pancreatic cancer: a multicenter retrospective analysis. AU - Ueda,Junji, AU - Tanaka,Masao, AU - Ohtsuka,Takao, AU - Tokunaga,Shoji, AU - Shimosegawa,Tooru, AU - ,, Y1 - 2012/09/16/ PY - 2011/07/18/received PY - 2012/08/03/accepted PY - 2012/9/20/entrez PY - 2012/9/20/pubmed PY - 2013/4/20/medline SP - 357 EP - 64 JF - Surgery JO - Surgery VL - 153 IS - 3 N2 - BACKGROUND: Chronic pancreatitis is suggested to be one of the risk factors for the development of pancreatic cancer. The aim of this study was to confirm the high incidence of pancreatic cancer in patients with chronic pancreatitis in Japan and to determine the factors associated with the risk for pancreatic cancer in patients with chronic pancreatitis. METHODS: The working group of the Research Committee of Intractable Disease supported by the Ministry of Health, Labour and Welfare of Japan carried out a nationwide survey to investigate the relationship between chronic pancreatitis and pancreatic cancer. This retrospective study included patients diagnosed with chronic pancreatitis who had had at least 2 years of follow-up. They were contacted through 22 Japanese referral centers experienced in the management of chronic pancreatitis. RESULTS: The standardized incidence ratio (95 CI) of pancreatic cancer was 11.8 (7.1-18.4). The incidence of pancreatic cancer was significantly lower in patients who had received surgery for chronic pancreatitis than in those who had not undergone surgery (hazard ratio estimated by Cox regression 0.11; 95% CI, 0.0014-0.80; P = .03). Patients who continued to drink alcohol after diagnosis of chronic pancreatitis showed a significantly higher incidence of pancreatic cancer than those who stopped drinking after diagnosis of chronic pancreatitis (hazard ratio, 5.07; 95% CI, 1.13-22.73; P = .03). CONCLUSION: This study confirmed that chronic pancreatitis is an important risk factor for the development of pancreatic cancer in Japan. Patients who underwent surgery for the treatment of chronic pancreatitis had significantly lower incidences of pancreatic cancer. Surgery for chronic pancreatitis may inhibit the development of pancreatic cancer in patients with chronic pancreatitis. SN - 1532-7361 UR - https://www.unboundmedicine.com/medline/citation/22989892/Surgery_for_chronic_pancreatitis_decreases_the_risk_for_pancreatic_cancer:_a_multicenter_retrospective_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0039-6060(12)00446-1 DB - PRIME DP - Unbound Medicine ER -