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Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents.
JAMA. 2012 Sep 19; 308(11):1113-21.JAMA

Abstract

CONTEXT

Bisphenol A (BPA), a manufactured chemical, is found in canned food, polycarbonate-bottled liquids, and other consumer products. In adults, elevated urinary BPA concentrations are associated with obesity and incident coronary artery disease. BPA exposure is plausibly linked to childhood obesity, but evidence is lacking to date.

OBJECTIVE

To examine associations between urinary BPA concentration and body mass outcomes in children.

DESIGN, SETTING, AND PARTICIPANTS

Cross-sectional analysis of a nationally representative subsample of 2838 participants aged 6 through 19 years randomly selected for measurement of urinary BPA concentration in the 2003-2008 National Health and Nutrition Examination Surveys.

MAIN OUTCOME MEASURES

Body mass index (BMI), converted to sex- and age-standardized z scores and used to classify participants as overweight (BMI ≥85th percentile for age/sex) or obese (BMI ≥95th percentile).

RESULTS

Median urinary BPA concentration was 2.8 ng/mL (interquartile range, 1.5-5.6). Of the participants, 1047 (34.1% [SE, 1.5%]) were overweight and 590 (17.8% [SE, 1.3%]) were obese. Controlling for race/ethnicity, age, caregiver education, poverty to income ratio, sex, serum cotinine level, caloric intake, television watching, and urinary creatinine level, children in the lowest urinary BPA quartile had a lower estimated prevalence of obesity (10.3% [95% CI, 7.5%-13.1%]) than those in quartiles 2 (20.1% [95% CI, 14.5%-25.6%]), 3 (19.0% [95% CI, 13.7%-24.2%]), and 4 (22.3% [95% CI, 16.6%-27.9%]). Similar patterns of association were found in multivariable analyses examining the association between quartiled urinary BPA concentration and BMI z score and in analyses that examined the logarithm of urinary BPA concentration and the prevalence of obesity. Obesity was not associated with exposure to other environmental phenols commonly used in other consumer products, such as sunscreens and soaps. In stratified analysis, significant associations between urinary BPA concentrations and obesity were found among whites (P < .001) but not among blacks or Hispanics.

CONCLUSIONS

Urinary BPA concentration was significantly associated with obesity in this cross-sectional study of children and adolescents. Explanations of the association cannot rule out the possibility that obese children ingest food with higher BPA content or have greater adipose stores of BPA.

Authors+Show Affiliations

Department of Pediatrics, New York University School of Medicine, New York, NY 10016, USA. leonardo.trasande@nyumc.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22990270

Citation

Trasande, Leonardo, et al. "Association Between Urinary Bisphenol a Concentration and Obesity Prevalence in Children and Adolescents." JAMA, vol. 308, no. 11, 2012, pp. 1113-21.
Trasande L, Attina TM, Blustein J. Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA. 2012;308(11):1113-21.
Trasande, L., Attina, T. M., & Blustein, J. (2012). Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA, 308(11), 1113-21.
Trasande L, Attina TM, Blustein J. Association Between Urinary Bisphenol a Concentration and Obesity Prevalence in Children and Adolescents. JAMA. 2012 Sep 19;308(11):1113-21. PubMed PMID: 22990270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. AU - Trasande,Leonardo, AU - Attina,Teresa M, AU - Blustein,Jan, PY - 2012/9/20/entrez PY - 2012/9/20/pubmed PY - 2012/9/21/medline SP - 1113 EP - 21 JF - JAMA JO - JAMA VL - 308 IS - 11 N2 - CONTEXT: Bisphenol A (BPA), a manufactured chemical, is found in canned food, polycarbonate-bottled liquids, and other consumer products. In adults, elevated urinary BPA concentrations are associated with obesity and incident coronary artery disease. BPA exposure is plausibly linked to childhood obesity, but evidence is lacking to date. OBJECTIVE: To examine associations between urinary BPA concentration and body mass outcomes in children. DESIGN, SETTING, AND PARTICIPANTS: Cross-sectional analysis of a nationally representative subsample of 2838 participants aged 6 through 19 years randomly selected for measurement of urinary BPA concentration in the 2003-2008 National Health and Nutrition Examination Surveys. MAIN OUTCOME MEASURES: Body mass index (BMI), converted to sex- and age-standardized z scores and used to classify participants as overweight (BMI ≥85th percentile for age/sex) or obese (BMI ≥95th percentile). RESULTS: Median urinary BPA concentration was 2.8 ng/mL (interquartile range, 1.5-5.6). Of the participants, 1047 (34.1% [SE, 1.5%]) were overweight and 590 (17.8% [SE, 1.3%]) were obese. Controlling for race/ethnicity, age, caregiver education, poverty to income ratio, sex, serum cotinine level, caloric intake, television watching, and urinary creatinine level, children in the lowest urinary BPA quartile had a lower estimated prevalence of obesity (10.3% [95% CI, 7.5%-13.1%]) than those in quartiles 2 (20.1% [95% CI, 14.5%-25.6%]), 3 (19.0% [95% CI, 13.7%-24.2%]), and 4 (22.3% [95% CI, 16.6%-27.9%]). Similar patterns of association were found in multivariable analyses examining the association between quartiled urinary BPA concentration and BMI z score and in analyses that examined the logarithm of urinary BPA concentration and the prevalence of obesity. Obesity was not associated with exposure to other environmental phenols commonly used in other consumer products, such as sunscreens and soaps. In stratified analysis, significant associations between urinary BPA concentrations and obesity were found among whites (P < .001) but not among blacks or Hispanics. CONCLUSIONS: Urinary BPA concentration was significantly associated with obesity in this cross-sectional study of children and adolescents. Explanations of the association cannot rule out the possibility that obese children ingest food with higher BPA content or have greater adipose stores of BPA. SN - 1538-3598 UR - https://www.unboundmedicine.com/medline/citation/22990270/Association_between_urinary_bisphenol_A_concentration_and_obesity_prevalence_in_children_and_adolescents_ L2 - https://jamanetwork.com/journals/jama/fullarticle/10.1001/2012.jama.11461 DB - PRIME DP - Unbound Medicine ER -