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Risk factors for acquisition of CTX-M-15 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae during an outbreak in a neonatal intensive care unit in Norway.
Scand J Infect Dis. 2013 Jan; 45(1):54-8.SJ

Abstract

BACKGROUND

A CTX-M-15 extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae was responsible for an outbreak in the neonatal intensive care unit (NICU) at Stavanger University Hospital, Norway over a 5-month period (November 2008-April 2009). The risk factors for acquiring ESBL-producing K. pneumoniae during the outbreak were examined in this study.

METHODS

Faecal or rectal cultures were obtained from infants hospitalized in the NICU during the outbreak period and examined for ESBL-producing K. pneumoniae. Data were retrospectively retrieved from the medical records, including sex, gestational age, birth weight, indwelling central vascular catheter, continuous positive airway pressure (CPAP), mechanical ventilation, parenteral nutrition, antibiotic treatment, mode of delivery (vaginal vs caesarean), length of hospital stay, and mortality.

RESULTS

A total of 216 infants were hospitalized in the NICU during the outbreak period, of whom 212 were screened; 51 (24%) scored positive for faecal colonization with ESBL-producing K. pneumoniae. One infant acquired a clinical infection. Forty-four colonized infants and 55 non-colonized infants were included in the risk analysis. Colonized infants had a lower birth weight, lower gestational age, and a longer hospital stay compared to non-colonized infants. By logistic regression, prematurity (gestational age <37 weeks) and treatment with antibiotics were independent risk factors for acquiring ESBL-producing K. pneumoniae in the final model.

CONCLUSION

Prematurity and treatment with antibiotics were independent risk factors for colonization during this NICU outbreak with ESBL-producing K. pneumoniae.

Authors+Show Affiliations

Department of Paediatrics, Stavanger University Hospital, PO Box 8100, 4068 Stavanger, Norway. sirenrettedal@yahoo.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22991960

Citation

Rettedal, Siren, et al. "Risk Factors for Acquisition of CTX-M-15 Extended-spectrum Beta-lactamase-producing Klebsiella Pneumoniae During an Outbreak in a Neonatal Intensive Care Unit in Norway." Scandinavian Journal of Infectious Diseases, vol. 45, no. 1, 2013, pp. 54-8.
Rettedal S, Høyland Löhr I, Natås O, et al. Risk factors for acquisition of CTX-M-15 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae during an outbreak in a neonatal intensive care unit in Norway. Scand J Infect Dis. 2013;45(1):54-8.
Rettedal, S., Høyland Löhr, I., Natås, O., Sundsfjord, A., & Øymar, K. (2013). Risk factors for acquisition of CTX-M-15 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae during an outbreak in a neonatal intensive care unit in Norway. Scandinavian Journal of Infectious Diseases, 45(1), 54-8. https://doi.org/10.3109/00365548.2012.713116
Rettedal S, et al. Risk Factors for Acquisition of CTX-M-15 Extended-spectrum Beta-lactamase-producing Klebsiella Pneumoniae During an Outbreak in a Neonatal Intensive Care Unit in Norway. Scand J Infect Dis. 2013;45(1):54-8. PubMed PMID: 22991960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for acquisition of CTX-M-15 extended-spectrum beta-lactamase-producing Klebsiella pneumoniae during an outbreak in a neonatal intensive care unit in Norway. AU - Rettedal,Siren, AU - Høyland Löhr,Iren, AU - Natås,Olav, AU - Sundsfjord,Arnfinn, AU - Øymar,Knut, Y1 - 2012/09/19/ PY - 2012/9/21/entrez PY - 2012/9/21/pubmed PY - 2013/8/21/medline SP - 54 EP - 8 JF - Scandinavian journal of infectious diseases JO - Scand. J. Infect. Dis. VL - 45 IS - 1 N2 - BACKGROUND: A CTX-M-15 extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae was responsible for an outbreak in the neonatal intensive care unit (NICU) at Stavanger University Hospital, Norway over a 5-month period (November 2008-April 2009). The risk factors for acquiring ESBL-producing K. pneumoniae during the outbreak were examined in this study. METHODS: Faecal or rectal cultures were obtained from infants hospitalized in the NICU during the outbreak period and examined for ESBL-producing K. pneumoniae. Data were retrospectively retrieved from the medical records, including sex, gestational age, birth weight, indwelling central vascular catheter, continuous positive airway pressure (CPAP), mechanical ventilation, parenteral nutrition, antibiotic treatment, mode of delivery (vaginal vs caesarean), length of hospital stay, and mortality. RESULTS: A total of 216 infants were hospitalized in the NICU during the outbreak period, of whom 212 were screened; 51 (24%) scored positive for faecal colonization with ESBL-producing K. pneumoniae. One infant acquired a clinical infection. Forty-four colonized infants and 55 non-colonized infants were included in the risk analysis. Colonized infants had a lower birth weight, lower gestational age, and a longer hospital stay compared to non-colonized infants. By logistic regression, prematurity (gestational age <37 weeks) and treatment with antibiotics were independent risk factors for acquiring ESBL-producing K. pneumoniae in the final model. CONCLUSION: Prematurity and treatment with antibiotics were independent risk factors for colonization during this NICU outbreak with ESBL-producing K. pneumoniae. SN - 1651-1980 UR - https://www.unboundmedicine.com/medline/citation/22991960/Risk_factors_for_acquisition_of_CTX_M_15_extended_spectrum_beta_lactamase_producing_Klebsiella_pneumoniae_during_an_outbreak_in_a_neonatal_intensive_care_unit_in_Norway_ L2 - http://www.tandfonline.com/doi/full/10.3109/00365548.2012.713116 DB - PRIME DP - Unbound Medicine ER -