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Homocysteine concentration and the risk of death in the adult Polish population.
Kardiol Pol. 2012; 70(9):897-902.KP

Abstract

BACKGROUND

Although there is a considerable epidemiologic evidence for a relation between homocysteine (Hcy) level and cardiovascular disease (CVD). The role of Hcy as a causal risk factor remains controversial.

AIM

To determine associations between Hcy level and all-cause and cardiovascular mortality in general population of Poland.

METHODS

Within the frame of the National Multicenter Health Survey (WOBASZ), a representative sample of whole Polish population aged 20-74 was screened in years 2003-2005 and prospectively followed up until 2009. Baseline determinations, among other classical risk factors, included Hcy level in 7165 responders, performed by an immunoenzymatic method using IMMULITE 1 analyser and DPC reagents. Survival rates were followed up until 2009 and average follow up time was 5.4 years.

RESULTS

During the 38,818.9 person-years of follow-up there were 270 deaths including 108 due to CVD, 37 due to coronary heart disease and 21 due to stroke. The relative risk of all-cause and CVD mortality was significantly higher in the highest (> 10.51 μmol/L) compared to the lowest (< 8.20 μmol/L) Hcy tercile in crude and multivariable proportional hazards models adjusted for sex, age, smoking status, hypertension, body mass index, total cholesterol, glucose and high sensitivity-C-reactive protein. Hazards ratios (95% confidence intervals) were as follows: all-cause mortality HR (95% CI): crude = 4.528 (2.947-6.154), multivariable-adjusted = 1.766 (1.197-2.605), CVD mortality crude = 4.322 (2.426-7.700), multivariable- -adjusted = 1.937 (1.051-3.569).

CONCLUSIONS

In Polish adult population Hcy concentration is independently associated with all-cause and CVD mortality.

Authors+Show Affiliations

Department of Epidemiology, Prevention of Cardiovascular Disease and Health Promotion, Institute of Cardiology, Warsaw, Poland. awaskiewicz@ikard.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22992997

Citation

Waśkiewicz, Anna, et al. "Homocysteine Concentration and the Risk of Death in the Adult Polish Population." Kardiologia Polska, vol. 70, no. 9, 2012, pp. 897-902.
Waśkiewicz A, Sygnowska E, Broda G. Homocysteine concentration and the risk of death in the adult Polish population. Kardiol Pol. 2012;70(9):897-902.
Waśkiewicz, A., Sygnowska, E., & Broda, G. (2012). Homocysteine concentration and the risk of death in the adult Polish population. Kardiologia Polska, 70(9), 897-902.
Waśkiewicz A, Sygnowska E, Broda G. Homocysteine Concentration and the Risk of Death in the Adult Polish Population. Kardiol Pol. 2012;70(9):897-902. PubMed PMID: 22992997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Homocysteine concentration and the risk of death in the adult Polish population. AU - Waśkiewicz,Anna, AU - Sygnowska,Elżbieta, AU - Broda,Grażyna, PY - 2012/9/21/entrez PY - 2012/9/21/pubmed PY - 2012/12/12/medline SP - 897 EP - 902 JF - Kardiologia polska JO - Kardiol Pol VL - 70 IS - 9 N2 - BACKGROUND: Although there is a considerable epidemiologic evidence for a relation between homocysteine (Hcy) level and cardiovascular disease (CVD). The role of Hcy as a causal risk factor remains controversial. AIM: To determine associations between Hcy level and all-cause and cardiovascular mortality in general population of Poland. METHODS: Within the frame of the National Multicenter Health Survey (WOBASZ), a representative sample of whole Polish population aged 20-74 was screened in years 2003-2005 and prospectively followed up until 2009. Baseline determinations, among other classical risk factors, included Hcy level in 7165 responders, performed by an immunoenzymatic method using IMMULITE 1 analyser and DPC reagents. Survival rates were followed up until 2009 and average follow up time was 5.4 years. RESULTS: During the 38,818.9 person-years of follow-up there were 270 deaths including 108 due to CVD, 37 due to coronary heart disease and 21 due to stroke. The relative risk of all-cause and CVD mortality was significantly higher in the highest (> 10.51 μmol/L) compared to the lowest (< 8.20 μmol/L) Hcy tercile in crude and multivariable proportional hazards models adjusted for sex, age, smoking status, hypertension, body mass index, total cholesterol, glucose and high sensitivity-C-reactive protein. Hazards ratios (95% confidence intervals) were as follows: all-cause mortality HR (95% CI): crude = 4.528 (2.947-6.154), multivariable-adjusted = 1.766 (1.197-2.605), CVD mortality crude = 4.322 (2.426-7.700), multivariable- -adjusted = 1.937 (1.051-3.569). CONCLUSIONS: In Polish adult population Hcy concentration is independently associated with all-cause and CVD mortality. SN - 1897-4279 UR - https://www.unboundmedicine.com/medline/citation/22992997/Homocysteine_concentration_and_the_risk_of_death_in_the_adult_Polish_population_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:22992997 DB - PRIME DP - Unbound Medicine ER -