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Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens.
Clin Exp Allergy 2012; 42(10):1529-39CE

Abstract

BACKGROUND

Multiple plant-food sensitizations with a complex pattern of clinical manifestations are a common feature of lipid transfer protein (LTP)-allergic patients. Component-resolved diagnosis permits the diagnosis of the allergen sensitization profile.

OBJECTIVE

We sought to clinically characterize and describe the plant-food and pollen molecular sensitization profile in patients with LTP syndrome.

METHODS

Forty-five subjects were recruited, after being diagnosed with multiple plant-food allergies sensitized to LTP, but not to any other plant-food allergen, according to the molecular allergen panel tested (Pru p 3 (LTP), Pru p 1 (Bet v 1-like), Pru p 4 (profilin) and those included in a commercial microarray of 103 allergenic components). IgE-mediated food-allergy symptoms and pollinosis were collected. Patients were skin prick tested with a plant-food and pollens panel, and specific IgE to Tri a 14 was evaluated.

RESULTS

A heterogeneous group of plant-foods was involved in local and systemic symptoms: oral allergy syndrome (75.6%), urticaria (66.7%), gastrointestinal disorders (55.6%) and anaphylaxis (75.6%), 32.4% of which were cofactor dependent (Non-Steroidal Anti-inflammatory Drugs, exercise). All tested subjects were positive to peach and Pru p 3, Tri a 14 and to some of the LTPs included in the microarray. Pollinosis was diagnosed in 75.6% of subjects, with a broad spectrum of pollen and pollen-allergen sensitization. Plane tree and mugwort were the statistically significant pollens associated with Pru p 3.

CONCLUSIONS AND CLINICAL RELEVANCE

Several plant-foods, taxonomically unrelated, independent of peach involvement, are implicated in LTP syndrome. Local symptoms should be evaluated as a risk marker for anaphylaxis because they are frequently associated with cofactor-dependent anaphylaxis. The association of these symptoms with pollinosis, especially plane tree pollinosis, could be part of this syndrome in our area.

Authors+Show Affiliations

Servei d'Immunologia, Centre de Diagnòstic Biomèdic, Hospital Clínic, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22994350

Citation

Pascal, M, et al. "Lipid Transfer Protein Syndrome: Clinical Pattern, Cofactor Effect and Profile of Molecular Sensitization to Plant-foods and Pollens." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 42, no. 10, 2012, pp. 1529-39.
Pascal M, Muñoz-Cano R, Reina Z, et al. Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. Clin Exp Allergy. 2012;42(10):1529-39.
Pascal, M., Muñoz-Cano, R., Reina, Z., Palacín, A., Vilella, R., Picado, C., ... Bartra, J. (2012). Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 42(10), pp. 1529-39. doi:10.1111/j.1365-2222.2012.04071.x.
Pascal M, et al. Lipid Transfer Protein Syndrome: Clinical Pattern, Cofactor Effect and Profile of Molecular Sensitization to Plant-foods and Pollens. Clin Exp Allergy. 2012;42(10):1529-39. PubMed PMID: 22994350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. AU - Pascal,M, AU - Muñoz-Cano,R, AU - Reina,Z, AU - Palacín,A, AU - Vilella,R, AU - Picado,C, AU - Juan,M, AU - Sánchez-López,J, AU - Rueda,M, AU - Salcedo,G, AU - Valero,A, AU - Yagüe,J, AU - Bartra,J, PY - 2012/9/22/entrez PY - 2012/9/22/pubmed PY - 2013/3/9/medline SP - 1529 EP - 39 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 42 IS - 10 N2 - BACKGROUND: Multiple plant-food sensitizations with a complex pattern of clinical manifestations are a common feature of lipid transfer protein (LTP)-allergic patients. Component-resolved diagnosis permits the diagnosis of the allergen sensitization profile. OBJECTIVE: We sought to clinically characterize and describe the plant-food and pollen molecular sensitization profile in patients with LTP syndrome. METHODS: Forty-five subjects were recruited, after being diagnosed with multiple plant-food allergies sensitized to LTP, but not to any other plant-food allergen, according to the molecular allergen panel tested (Pru p 3 (LTP), Pru p 1 (Bet v 1-like), Pru p 4 (profilin) and those included in a commercial microarray of 103 allergenic components). IgE-mediated food-allergy symptoms and pollinosis were collected. Patients were skin prick tested with a plant-food and pollens panel, and specific IgE to Tri a 14 was evaluated. RESULTS: A heterogeneous group of plant-foods was involved in local and systemic symptoms: oral allergy syndrome (75.6%), urticaria (66.7%), gastrointestinal disorders (55.6%) and anaphylaxis (75.6%), 32.4% of which were cofactor dependent (Non-Steroidal Anti-inflammatory Drugs, exercise). All tested subjects were positive to peach and Pru p 3, Tri a 14 and to some of the LTPs included in the microarray. Pollinosis was diagnosed in 75.6% of subjects, with a broad spectrum of pollen and pollen-allergen sensitization. Plane tree and mugwort were the statistically significant pollens associated with Pru p 3. CONCLUSIONS AND CLINICAL RELEVANCE: Several plant-foods, taxonomically unrelated, independent of peach involvement, are implicated in LTP syndrome. Local symptoms should be evaluated as a risk marker for anaphylaxis because they are frequently associated with cofactor-dependent anaphylaxis. The association of these symptoms with pollinosis, especially plane tree pollinosis, could be part of this syndrome in our area. SN - 1365-2222 UR - https://www.unboundmedicine.com/medline/citation/22994350/Lipid_transfer_protein_syndrome:_clinical_pattern_cofactor_effect_and_profile_of_molecular_sensitization_to_plant_foods_and_pollens_ L2 - https://doi.org/10.1111/j.1365-2222.2012.04071.x DB - PRIME DP - Unbound Medicine ER -