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Pure and mixed mucinous carcinoma of the breast: fine needle aspiration cytology findings and review of the literature.
Cytopathology. 2013 Dec; 24(6):377-84.C

Abstract

OBJECTIVE

Mucinous (colloid) breast carcinoma accounts for 1-6% of all breast cancer. It comprises pure mucinous tumours and mixed infiltrating ductal carcinomas with a mucinous component. As this latter mixed form has a worse prognosis than pure colloid carcinoma, making this diagnosis on fine needle aspiration cytology (FNAC) might influence the choice of treatment.

METHODS

We report a consecutive series of 22 cases consisting of 17 mixed and five pure mucinous carcinomas diagnosed by cytology and verified on histopathology. Patients underwent FNAC at the one-stop clinic of our institution during a 7-year period of time. Cytological findings were evaluated by a semi-quantitative method and included percentage of smear surface occupied by mucin, shape of cell groupings, size and outline of tumour nuclei as well as presence or absence of nucleolus.

RESULTS

Three of five pure mucinous carcinomas displayed at least two of the following features: abundant mucin, small nuclei and/or regular nuclear outlines. Sparse mucin, large nuclei, irregular nuclear outlines or the presence of nucleoli were found in 7 out of 17 mixed mucinous carcinomas but not in pure tumours.

CONCLUSION

Cytopathological identification of patients with pure mucinous carcinomas may be performed in a limited number of cases.

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Authors+Show Affiliations

Cyrta J
Departments of Biology and PathologyRadiologyRadiotherapySurgeryMedicine, Institut de cancérologie Gustave Roussy, Villejuif, France.
Andreiuolo F
No affiliation info available
Azoulay S
No affiliation info available
Balleyguier C
No affiliation info available
Bourgier C
No affiliation info available
Mazouni C
No affiliation info available
Mathieu MC
No affiliation info available
Delaloge S
No affiliation info available
Vielh P
No affiliation info available

MeSH

Adenocarcinoma, MucinousAgedAged, 80 and overAxillaBiopsy, Fine-NeedleBreastBreast NeoplasmsFemaleHumansLymph NodesMastectomy, SegmentalMiddle Aged

Pub Type(s)

Case Reports
Comparative Study
Journal Article
Review

Language

eng

PubMed ID

22994403

Citation

Cyrta, J, et al. "Pure and Mixed Mucinous Carcinoma of the Breast: Fine Needle Aspiration Cytology Findings and Review of the Literature." Cytopathology : Official Journal of the British Society for Clinical Cytology, vol. 24, no. 6, 2013, pp. 377-84.
Cyrta J, Andreiuolo F, Azoulay S, et al. Pure and mixed mucinous carcinoma of the breast: fine needle aspiration cytology findings and review of the literature. Cytopathology. 2013;24(6):377-84.
Cyrta, J., Andreiuolo, F., Azoulay, S., Balleyguier, C., Bourgier, C., Mazouni, C., Mathieu, M. C., Delaloge, S., & Vielh, P. (2013). Pure and mixed mucinous carcinoma of the breast: fine needle aspiration cytology findings and review of the literature. Cytopathology : Official Journal of the British Society for Clinical Cytology, 24(6), 377-84. https://doi.org/10.1111/cyt.12016
Cyrta J, et al. Pure and Mixed Mucinous Carcinoma of the Breast: Fine Needle Aspiration Cytology Findings and Review of the Literature. Cytopathology. 2013;24(6):377-84. PubMed PMID: 22994403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pure and mixed mucinous carcinoma of the breast: fine needle aspiration cytology findings and review of the literature. AU - Cyrta,J, AU - Andreiuolo,F, AU - Azoulay,S, AU - Balleyguier,C, AU - Bourgier,C, AU - Mazouni,C, AU - Mathieu,M-C, AU - Delaloge,S, AU - Vielh,P, Y1 - 2012/09/21/ PY - 2012/9/22/entrez PY - 2012/9/22/pubmed PY - 2014/8/5/medline KW - breast cancer KW - colloid KW - cytology KW - fine needle aspiration KW - mixed KW - mucinous KW - pure SP - 377 EP - 84 JF - Cytopathology : official journal of the British Society for Clinical Cytology JO - Cytopathology VL - 24 IS - 6 N2 - OBJECTIVE: Mucinous (colloid) breast carcinoma accounts for 1-6% of all breast cancer. It comprises pure mucinous tumours and mixed infiltrating ductal carcinomas with a mucinous component. As this latter mixed form has a worse prognosis than pure colloid carcinoma, making this diagnosis on fine needle aspiration cytology (FNAC) might influence the choice of treatment. METHODS: We report a consecutive series of 22 cases consisting of 17 mixed and five pure mucinous carcinomas diagnosed by cytology and verified on histopathology. Patients underwent FNAC at the one-stop clinic of our institution during a 7-year period of time. Cytological findings were evaluated by a semi-quantitative method and included percentage of smear surface occupied by mucin, shape of cell groupings, size and outline of tumour nuclei as well as presence or absence of nucleolus. RESULTS: Three of five pure mucinous carcinomas displayed at least two of the following features: abundant mucin, small nuclei and/or regular nuclear outlines. Sparse mucin, large nuclei, irregular nuclear outlines or the presence of nucleoli were found in 7 out of 17 mixed mucinous carcinomas but not in pure tumours. CONCLUSION: Cytopathological identification of patients with pure mucinous carcinomas may be performed in a limited number of cases. SN - 1365-2303 UR - https://www.unboundmedicine.com/medline/citation/22994403/Pure_and_mixed_mucinous_carcinoma_of_the_breast:_fine_needle_aspiration_cytology_findings_and_review_of_the_literature_ L2 - https://doi.org/10.1111/cyt.12016 DB - PRIME DP - Unbound Medicine ER -