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[Risk factors for myocardial remodeling at stage II-IV of chronic kidney disease].
Ter Arkh. 2012; 84(6):21-6.TA

Abstract

AIM

To evaluate frequency and risk factors of development of left ventricular hypertrophy (LVH) of the heart in patients with chronic kidney disease (CKD) of stage II-IV.

MATERIAL AND METHODS

The trial enrolled 83 patients (42 - 51% males, 41 - 49% females, mean age 46.7 years) with stage II-IV CKD of non-diabetic origin. Glomerular filtration rate (GFR) estimated according to Cockroft-Goult formula was 37,7 ml/min (95% confidence interval from 33,9 do 41,4). Chronic renal failure duration averaged 2,7 years (95 % CI from 2.0 to 3.3). Arterial hypertension (AH) was diagnosed in 96% patients, hereditary predisposition to cardiovascular diseases - in 54%, obesity - in 60%. lipid disbolism - in 66%, anemia - in 34 % and hyperphosphatemia - in 45%; 40% patients smoked. Echocardiography was performed in all the patients.

RESULTS

LVH was detected in 31 (37.3%) of 83 patients. With progression of renal failure, frequency of registration of LVH increased LVH onset was associated with conventional (age, AH, high level of total cholesterol) and renal (lowering of GFR, anemia, hyperphosphatemia) factors. Concentric remodeling, concentric LVH, eccentric LVH were detected in 31.3, 19.3 and 18.1% patients, respectively. Eccentric LVH developed more frequently under the influence of factors associated with renal failure (GFR, anemia, hyperphosphatemia, hypocalcemia). Concentric LVH was characterized with the highest systolic blood pressure.

CONCLUSION

Patients with renal dysfunction develop LVH of different geometric model associated with both conventional and renal risk factors even at early stages of CKD.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

22997913

Citation

Rudenko, T E., et al. "[Risk Factors for Myocardial Remodeling at Stage II-IV of Chronic Kidney Disease]." Terapevticheskii Arkhiv, vol. 84, no. 6, 2012, pp. 21-6.
Rudenko TE, Kutyrina IM, Shvetsov MIu. [Risk factors for myocardial remodeling at stage II-IV of chronic kidney disease]. Ter Arkh. 2012;84(6):21-6.
Rudenko, T. E., Kutyrina, I. M., & Shvetsov, M. I. u. (2012). [Risk factors for myocardial remodeling at stage II-IV of chronic kidney disease]. Terapevticheskii Arkhiv, 84(6), 21-6.
Rudenko TE, Kutyrina IM, Shvetsov MIu. [Risk Factors for Myocardial Remodeling at Stage II-IV of Chronic Kidney Disease]. Ter Arkh. 2012;84(6):21-6. PubMed PMID: 22997913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Risk factors for myocardial remodeling at stage II-IV of chronic kidney disease]. AU - Rudenko,T E, AU - Kutyrina,I M, AU - Shvetsov,M Iu, PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2012/12/10/medline SP - 21 EP - 6 JF - Terapevticheskii arkhiv JO - Ter Arkh VL - 84 IS - 6 N2 - AIM: To evaluate frequency and risk factors of development of left ventricular hypertrophy (LVH) of the heart in patients with chronic kidney disease (CKD) of stage II-IV. MATERIAL AND METHODS: The trial enrolled 83 patients (42 - 51% males, 41 - 49% females, mean age 46.7 years) with stage II-IV CKD of non-diabetic origin. Glomerular filtration rate (GFR) estimated according to Cockroft-Goult formula was 37,7 ml/min (95% confidence interval from 33,9 do 41,4). Chronic renal failure duration averaged 2,7 years (95 % CI from 2.0 to 3.3). Arterial hypertension (AH) was diagnosed in 96% patients, hereditary predisposition to cardiovascular diseases - in 54%, obesity - in 60%. lipid disbolism - in 66%, anemia - in 34 % and hyperphosphatemia - in 45%; 40% patients smoked. Echocardiography was performed in all the patients. RESULTS: LVH was detected in 31 (37.3%) of 83 patients. With progression of renal failure, frequency of registration of LVH increased LVH onset was associated with conventional (age, AH, high level of total cholesterol) and renal (lowering of GFR, anemia, hyperphosphatemia) factors. Concentric remodeling, concentric LVH, eccentric LVH were detected in 31.3, 19.3 and 18.1% patients, respectively. Eccentric LVH developed more frequently under the influence of factors associated with renal failure (GFR, anemia, hyperphosphatemia, hypocalcemia). Concentric LVH was characterized with the highest systolic blood pressure. CONCLUSION: Patients with renal dysfunction develop LVH of different geometric model associated with both conventional and renal risk factors even at early stages of CKD. SN - 0040-3660 UR - https://www.unboundmedicine.com/medline/citation/22997913/[Risk_factors_for_myocardial_remodeling_at_stage_II_IV_of_chronic_kidney_disease]_ L2 - http://www.diseaseinfosearch.org/result/3996 DB - PRIME DP - Unbound Medicine ER -