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Autonomic symptoms and dopaminergic treatment in de novo Parkinson's disease.
Acta Neurol Scand. 2013 Apr; 127(4):290-4.AN

Abstract

OBJECTIVES

Autonomic symptoms are present in early stages of Parkinson's disease (PD), but evidence on how they are influenced by dopaminergic treatment remains unclear. The aim of this study was to investigate the impact of dopaminergic treatment on autonomic symptoms in early PD in a population-based cohort.

METHODS

A total of 171 drug-naive patients with PD were investigated at diagnosis and 12 months later. Orthostatic blood pressure was measured, and autonomic symptoms were assessed by a preliminary version of the Movement Disorders Society-sponsored new version of the Unified Parkinson's Disease Rating Scale (range 0-4).

RESULTS

In the 82% using dopaminergic treatment after 1 year, constipation and orthostatic blood pressure drop increased. There was a tendency towards increased orthostatic dizziness and urinary dysfunction. Dysphagia scores were reduced, and this was associated with higher levodopa-equivalent daily dose.

CONCLUSIONS

Dopaminergic treatment during the first year after initiation seems to have only a minor impact on autonomic symptoms in early PD. It may increase constipation and orthostatic dizziness, while dysphagia can improve. Autonomic symptoms remained mild after 1 year of dopaminergic treatment.

Authors+Show Affiliations

Department of Neurology, Haukeland University Hospital, Bergen, Norway. bernd.muller@helse-bergen.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22998158

Citation

Müller, B, et al. "Autonomic Symptoms and Dopaminergic Treatment in De Novo Parkinson's Disease." Acta Neurologica Scandinavica, vol. 127, no. 4, 2013, pp. 290-4.
Müller B, Assmus J, Larsen JP, et al. Autonomic symptoms and dopaminergic treatment in de novo Parkinson's disease. Acta Neurol Scand. 2013;127(4):290-4.
Müller, B., Assmus, J., Larsen, J. P., Haugarvoll, K., Skeie, G. O., & Tysnes, O. B. (2013). Autonomic symptoms and dopaminergic treatment in de novo Parkinson's disease. Acta Neurologica Scandinavica, 127(4), 290-4. https://doi.org/10.1111/ane.12010
Müller B, et al. Autonomic Symptoms and Dopaminergic Treatment in De Novo Parkinson's Disease. Acta Neurol Scand. 2013;127(4):290-4. PubMed PMID: 22998158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autonomic symptoms and dopaminergic treatment in de novo Parkinson's disease. AU - Müller,B, AU - Assmus,J, AU - Larsen,J P, AU - Haugarvoll,K, AU - Skeie,G O, AU - Tysnes,O-B, AU - ,, Y1 - 2012/09/23/ PY - 2012/8/14/accepted PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/9/11/medline SP - 290 EP - 4 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 127 IS - 4 N2 - OBJECTIVES: Autonomic symptoms are present in early stages of Parkinson's disease (PD), but evidence on how they are influenced by dopaminergic treatment remains unclear. The aim of this study was to investigate the impact of dopaminergic treatment on autonomic symptoms in early PD in a population-based cohort. METHODS: A total of 171 drug-naive patients with PD were investigated at diagnosis and 12 months later. Orthostatic blood pressure was measured, and autonomic symptoms were assessed by a preliminary version of the Movement Disorders Society-sponsored new version of the Unified Parkinson's Disease Rating Scale (range 0-4). RESULTS: In the 82% using dopaminergic treatment after 1 year, constipation and orthostatic blood pressure drop increased. There was a tendency towards increased orthostatic dizziness and urinary dysfunction. Dysphagia scores were reduced, and this was associated with higher levodopa-equivalent daily dose. CONCLUSIONS: Dopaminergic treatment during the first year after initiation seems to have only a minor impact on autonomic symptoms in early PD. It may increase constipation and orthostatic dizziness, while dysphagia can improve. Autonomic symptoms remained mild after 1 year of dopaminergic treatment. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/22998158/Autonomic_symptoms_and_dopaminergic_treatment_in_de_novo_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -