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Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans.
Free Radic Biol Med 2012; 53(10):1848-56FR

Abstract

In modern times, there has been a major increase in the use of plants or herbal constituents for the prevention of age-related disorders. 4-Hydroxy-E-globularinin (4-HEG) is an iridoid and a major component of Premna integrifolia. This investigation represents a breakthrough in geriatrics by showing the longevity-promoting activity of 4-HEG in the animal model Caenorhabditis elegans. 4-HEG (20μM) enhanced the mean life span of worms by over 18.8% under normal culture conditions and also enhanced their survival under oxidative stress. The longevity-promoting activity was associated with reduced reactive oxygen species (ROS) levels and fat accumulation in the worms. Gene-specific mutant studies verified the role of ROS detoxification pathways and simultaneous nuclear translocation of DAF-16 in the 4-HEG-mediated effects. Quantitative real-time PCR estimations and observations of transcriptional reporters indicated that 4-HEG was able to upregulate stress-inducible genes, viz., hsp-16.2 and sod-3. Thus, 4-HEG may serve as a lead compound of plant origin for the development of important nutraceuticals superseding the aging process.

Authors+Show Affiliations

Microbial Technology and Nematology, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23000058

Citation

Shukla, Virendra, et al. "Longevity-promoting Effects of 4-hydroxy-E-globularinin in Caenorhabditis Elegans." Free Radical Biology & Medicine, vol. 53, no. 10, 2012, pp. 1848-56.
Shukla V, Yadav D, Phulara SC, et al. Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radic Biol Med. 2012;53(10):1848-56.
Shukla, V., Yadav, D., Phulara, S. C., Gupta, M. M., Saikia, S. K., & Pandey, R. (2012). Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. Free Radical Biology & Medicine, 53(10), pp. 1848-56. doi:10.1016/j.freeradbiomed.2012.08.594.
Shukla V, et al. Longevity-promoting Effects of 4-hydroxy-E-globularinin in Caenorhabditis Elegans. Free Radic Biol Med. 2012 Nov 15;53(10):1848-56. PubMed PMID: 23000058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans. AU - Shukla,Virendra, AU - Yadav,Deepti, AU - Phulara,Suresh C, AU - Gupta,M M, AU - Saikia,Shilpi K, AU - Pandey,Rakesh, Y1 - 2012/09/07/ PY - 2012/04/10/received PY - 2012/08/17/revised PY - 2012/08/24/accepted PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/6/12/medline SP - 1848 EP - 56 JF - Free radical biology & medicine JO - Free Radic. Biol. Med. VL - 53 IS - 10 N2 - In modern times, there has been a major increase in the use of plants or herbal constituents for the prevention of age-related disorders. 4-Hydroxy-E-globularinin (4-HEG) is an iridoid and a major component of Premna integrifolia. This investigation represents a breakthrough in geriatrics by showing the longevity-promoting activity of 4-HEG in the animal model Caenorhabditis elegans. 4-HEG (20μM) enhanced the mean life span of worms by over 18.8% under normal culture conditions and also enhanced their survival under oxidative stress. The longevity-promoting activity was associated with reduced reactive oxygen species (ROS) levels and fat accumulation in the worms. Gene-specific mutant studies verified the role of ROS detoxification pathways and simultaneous nuclear translocation of DAF-16 in the 4-HEG-mediated effects. Quantitative real-time PCR estimations and observations of transcriptional reporters indicated that 4-HEG was able to upregulate stress-inducible genes, viz., hsp-16.2 and sod-3. Thus, 4-HEG may serve as a lead compound of plant origin for the development of important nutraceuticals superseding the aging process. SN - 1873-4596 UR - https://www.unboundmedicine.com/medline/citation/23000058/Longevity_promoting_effects_of_4_hydroxy_E_globularinin_in_Caenorhabditis_elegans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5849(12)01111-2 DB - PRIME DP - Unbound Medicine ER -