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Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling.
Life Sci. 2012 Nov 02; 91(19-20):935-43.LS

Abstract

AIMS

The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice.

MAIN METHODS

To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice.

KEY FINDINGS

Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells.

SIGNIFICANCE

This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.

Authors+Show Affiliations

Bioscience Research Institute, AmorePacific Corporation R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin 446-729, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23000887

Citation

Park, Phil-June, et al. "Hair Growth-promoting Effect of Aconiti Ciliare Tuber Extract Mediated By the Activation of Wnt/β-catenin Signaling." Life Sciences, vol. 91, no. 19-20, 2012, pp. 935-43.
Park PJ, Moon BS, Lee SH, et al. Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling. Life Sci. 2012;91(19-20):935-43.
Park, P. J., Moon, B. S., Lee, S. H., Kim, S. N., Kim, A. R., Kim, H. J., Park, W. S., Choi, K. Y., Cho, E. G., & Lee, T. R. (2012). Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling. Life Sciences, 91(19-20), 935-43. https://doi.org/10.1016/j.lfs.2012.09.008
Park PJ, et al. Hair Growth-promoting Effect of Aconiti Ciliare Tuber Extract Mediated By the Activation of Wnt/β-catenin Signaling. Life Sci. 2012 Nov 2;91(19-20):935-43. PubMed PMID: 23000887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling. AU - Park,Phil-June, AU - Moon,Byoung-San, AU - Lee,Soung-Hoon, AU - Kim,Su-Na, AU - Kim,Ah-Reum, AU - Kim,Hyung-Jun, AU - Park,Won-Seok, AU - Choi,Kang-Yell, AU - Cho,Eun-Gyung, AU - Lee,Tae Ryong, Y1 - 2012/09/21/ PY - 2012/06/13/received PY - 2012/08/31/revised PY - 2012/09/07/accepted PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/1/5/medline SP - 935 EP - 43 JF - Life sciences JO - Life Sci VL - 91 IS - 19-20 N2 - AIMS: The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice. MAIN METHODS: To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice. KEY FINDINGS: Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells. SIGNIFICANCE: This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/23000887/Hair_growth_promoting_effect_of_Aconiti_Ciliare_Tuber_extract_mediated_by_the_activation_of_Wnt/β_catenin_signaling_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(12)00507-3 DB - PRIME DP - Unbound Medicine ER -