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Prevalence of diabetes mellitus in pancreatic cancer compared to common cancers.
Pancreas 2013; 42(2):198-201P

Abstract

OBJECTIVES

In pancreatic cancer (PaC), the prevalence of diabetes mellitus (DM), especially new-onset DM (≤36 months of PaC diagnosis), is high. To determine if this observation is unique to PaC, we compared the prevalence and characteristics of DM in lung, breast, prostate, and colorectal cancers with PaC and noncancer controls.

METHODS

We retrospectively reviewed the medical records of 500 consecutive patients with cancer (100 each with lung, breast, prostate, and colorectal cancers and PaC) and 100 noncancer controls.

RESULTS

Patients with PaC (mean age ± SD, 71.6 ± 9.4 years; 53% men) had a significantly (P < 0.0001) higher prevalence of DM (68%) compared to age-matched patients with lung (mean age ± SD, 71.6 ± 9.4 years; 59% men; and 19.6% DM), breast (mean age ± SD, 71.6 ± 9.6 years; 100% women; and 19.4% DM), prostate (mean age ± SD, 71.3 ± 9.4 years; 100% men; and 14.8% DM), and colorectal cancer (mean age ± SD, 71.6 ± 9.5 years; 56% men; and 20.7% DM), and noncancer controls (mean age ± SD, 70.7 ± 9.2 years; 57% men; and 23.5% DM). Among the patients with PaC, 40% developed DM in the 36 months preceding the diagnosis of PaC compared with 3.3% to 5.7% in the other groups (P < 0.0001).

CONCLUSIONS

Whereas the prevalence of DM in PaC is very high, DM prevalence in other common cancers is no different from that in noncancer controls. In particular, new-onset DM is a phenomenon that is unique to PaC.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Mayo Clinic Collegeof Medicine, Rochester, MN 55905, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

23000893

Citation

Aggarwal, Gaurav, et al. "Prevalence of Diabetes Mellitus in Pancreatic Cancer Compared to Common Cancers." Pancreas, vol. 42, no. 2, 2013, pp. 198-201.
Aggarwal G, Kamada P, Chari ST. Prevalence of diabetes mellitus in pancreatic cancer compared to common cancers. Pancreas. 2013;42(2):198-201.
Aggarwal, G., Kamada, P., & Chari, S. T. (2013). Prevalence of diabetes mellitus in pancreatic cancer compared to common cancers. Pancreas, 42(2), pp. 198-201. doi:10.1097/MPA.0b013e3182592c96.
Aggarwal G, Kamada P, Chari ST. Prevalence of Diabetes Mellitus in Pancreatic Cancer Compared to Common Cancers. Pancreas. 2013;42(2):198-201. PubMed PMID: 23000893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of diabetes mellitus in pancreatic cancer compared to common cancers. AU - Aggarwal,Gaurav, AU - Kamada,Pratima, AU - Chari,Suresh T, PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/7/23/medline SP - 198 EP - 201 JF - Pancreas JO - Pancreas VL - 42 IS - 2 N2 - OBJECTIVES: In pancreatic cancer (PaC), the prevalence of diabetes mellitus (DM), especially new-onset DM (≤36 months of PaC diagnosis), is high. To determine if this observation is unique to PaC, we compared the prevalence and characteristics of DM in lung, breast, prostate, and colorectal cancers with PaC and noncancer controls. METHODS: We retrospectively reviewed the medical records of 500 consecutive patients with cancer (100 each with lung, breast, prostate, and colorectal cancers and PaC) and 100 noncancer controls. RESULTS: Patients with PaC (mean age ± SD, 71.6 ± 9.4 years; 53% men) had a significantly (P < 0.0001) higher prevalence of DM (68%) compared to age-matched patients with lung (mean age ± SD, 71.6 ± 9.4 years; 59% men; and 19.6% DM), breast (mean age ± SD, 71.6 ± 9.6 years; 100% women; and 19.4% DM), prostate (mean age ± SD, 71.3 ± 9.4 years; 100% men; and 14.8% DM), and colorectal cancer (mean age ± SD, 71.6 ± 9.5 years; 56% men; and 20.7% DM), and noncancer controls (mean age ± SD, 70.7 ± 9.2 years; 57% men; and 23.5% DM). Among the patients with PaC, 40% developed DM in the 36 months preceding the diagnosis of PaC compared with 3.3% to 5.7% in the other groups (P < 0.0001). CONCLUSIONS: Whereas the prevalence of DM in PaC is very high, DM prevalence in other common cancers is no different from that in noncancer controls. In particular, new-onset DM is a phenomenon that is unique to PaC. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/23000893/Prevalence_of_diabetes_mellitus_in_pancreatic_cancer_compared_to_common_cancers_ L2 - http://Insights.ovid.com/pubmed?pmid=23000893 DB - PRIME DP - Unbound Medicine ER -