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Effect of statins on skeletal muscle: exercise, myopathy, and muscle outcomes.
Exerc Sport Sci Rev. 2012 Oct; 40(4):188-94.ES

Abstract

Statins are effective in reducing low-density lipoprotein cholesterol and cardiac events but can produce muscle side effects. We have hypothesized that statin-related muscle complaints are exacerbated by exercise and influenced by factors including mitochondrial dysfunction, membrane disruption, and/or calcium handling. The interaction between statins, exercise, and muscle symptoms may be more effectively diagnosed and treated as rigorous scientific studies accumulate.

Authors+Show Affiliations

Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06012, USA. bparker03@harthosp.orgNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

23000957

Citation

Parker, Beth A., and Paul D. Thompson. "Effect of Statins On Skeletal Muscle: Exercise, Myopathy, and Muscle Outcomes." Exercise and Sport Sciences Reviews, vol. 40, no. 4, 2012, pp. 188-94.
Parker BA, Thompson PD. Effect of statins on skeletal muscle: exercise, myopathy, and muscle outcomes. Exerc Sport Sci Rev. 2012;40(4):188-94.
Parker, B. A., & Thompson, P. D. (2012). Effect of statins on skeletal muscle: exercise, myopathy, and muscle outcomes. Exercise and Sport Sciences Reviews, 40(4), 188-94.
Parker BA, Thompson PD. Effect of Statins On Skeletal Muscle: Exercise, Myopathy, and Muscle Outcomes. Exerc Sport Sci Rev. 2012;40(4):188-94. PubMed PMID: 23000957.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of statins on skeletal muscle: exercise, myopathy, and muscle outcomes. AU - Parker,Beth A, AU - Thompson,Paul D, PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/2/12/medline SP - 188 EP - 94 JF - Exercise and sport sciences reviews JO - Exerc Sport Sci Rev VL - 40 IS - 4 N2 - Statins are effective in reducing low-density lipoprotein cholesterol and cardiac events but can produce muscle side effects. We have hypothesized that statin-related muscle complaints are exacerbated by exercise and influenced by factors including mitochondrial dysfunction, membrane disruption, and/or calcium handling. The interaction between statins, exercise, and muscle symptoms may be more effectively diagnosed and treated as rigorous scientific studies accumulate. SN - 1538-3008 UR - https://www.unboundmedicine.com/medline/citation/23000957/Effect_of_statins_on_skeletal_muscle:_exercise_myopathy_and_muscle_outcomes_ L2 - http://dx.doi.org/10.1097/JES.0b013e31826c169e DB - PRIME DP - Unbound Medicine ER -