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Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats.
Eur J Pharmacol. 2012 Dec 05; 696(1-3):62-9.EJ

Abstract

Oxaliplatin and paclitaxel are commonly used anti-cancer drugs, but they frequently cause peripheral neuropathic pain. In this study, we investigated the effect of elcatonin, a synthetic eel calcitonin, on oxaliplatin- and paclitaxel-induced neuropathy in rats. The rats were treated with a single dose of oxaliplatin (6 mg/kg, i.p.) or repeated doses of paclitaxel (2 mg/kg, i.p.) on 4 alternate days. Both treatments resulted in cold and mechanical allodynia. We assessed the anti-allodynic effects of subcutaneously administered elcatonin (20 U/kg/day) by using a newly developed method to provide cold stimulation (8°C) directly to the hind paw of the rats and by using the von Frey test. Elcatonin almost completely reversed the effects of both cold and mechanical allodynia. To determine the mechanism of this anti-allodynic effect, we examined the effect of elcatonin on neuropathy induced by intraplantar injection of two organic compounds: allyl isothiocyanate (1 nmol/paw), which activates transient receptor potential ankyrin-1 channels, and menthol (1.28 μmol/paw), which activates transient receptor potential ankyrin-1 and melastatin-8. Pre-administration of elcatonin almost completely prevented cold and mechanical allodynia from being induced by both compounds. These results suggest that elcatonin attenuates oxaliplatin- and paclitaxel-induced neuropathic pain by inhibiting the cellular signaling related to transient receptor potential ankyrin-1 and melastatin-8. Thus, we conclude that administration of elcatonin may improve the quality of life of cancer patients receiving chemotherapy.

Authors+Show Affiliations

Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences, 9-1 Shirokane 5-chome, Tokyo 108-8641, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23001015

Citation

Aoki, Manahito, et al. "Effect of Synthetic Eel Calcitonin, Elcatonin, On Cold and Mechanical Allodynia Induced By Oxaliplatin and Paclitaxel in Rats." European Journal of Pharmacology, vol. 696, no. 1-3, 2012, pp. 62-9.
Aoki M, Mori A, Nakahara T, et al. Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats. Eur J Pharmacol. 2012;696(1-3):62-9.
Aoki, M., Mori, A., Nakahara, T., Sakamoto, K., & Ishii, K. (2012). Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats. European Journal of Pharmacology, 696(1-3), 62-9. https://doi.org/10.1016/j.ejphar.2012.09.007
Aoki M, et al. Effect of Synthetic Eel Calcitonin, Elcatonin, On Cold and Mechanical Allodynia Induced By Oxaliplatin and Paclitaxel in Rats. Eur J Pharmacol. 2012 Dec 5;696(1-3):62-9. PubMed PMID: 23001015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of synthetic eel calcitonin, elcatonin, on cold and mechanical allodynia induced by oxaliplatin and paclitaxel in rats. AU - Aoki,Manahito, AU - Mori,Asami, AU - Nakahara,Tsutomu, AU - Sakamoto,Kenji, AU - Ishii,Kunio, Y1 - 2012/09/19/ PY - 2012/02/14/received PY - 2012/08/27/revised PY - 2012/09/06/accepted PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/4/18/medline SP - 62 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 696 IS - 1-3 N2 - Oxaliplatin and paclitaxel are commonly used anti-cancer drugs, but they frequently cause peripheral neuropathic pain. In this study, we investigated the effect of elcatonin, a synthetic eel calcitonin, on oxaliplatin- and paclitaxel-induced neuropathy in rats. The rats were treated with a single dose of oxaliplatin (6 mg/kg, i.p.) or repeated doses of paclitaxel (2 mg/kg, i.p.) on 4 alternate days. Both treatments resulted in cold and mechanical allodynia. We assessed the anti-allodynic effects of subcutaneously administered elcatonin (20 U/kg/day) by using a newly developed method to provide cold stimulation (8°C) directly to the hind paw of the rats and by using the von Frey test. Elcatonin almost completely reversed the effects of both cold and mechanical allodynia. To determine the mechanism of this anti-allodynic effect, we examined the effect of elcatonin on neuropathy induced by intraplantar injection of two organic compounds: allyl isothiocyanate (1 nmol/paw), which activates transient receptor potential ankyrin-1 channels, and menthol (1.28 μmol/paw), which activates transient receptor potential ankyrin-1 and melastatin-8. Pre-administration of elcatonin almost completely prevented cold and mechanical allodynia from being induced by both compounds. These results suggest that elcatonin attenuates oxaliplatin- and paclitaxel-induced neuropathic pain by inhibiting the cellular signaling related to transient receptor potential ankyrin-1 and melastatin-8. Thus, we conclude that administration of elcatonin may improve the quality of life of cancer patients receiving chemotherapy. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/23001015/Effect_of_synthetic_eel_calcitonin_elcatonin_on_cold_and_mechanical_allodynia_induced_by_oxaliplatin_and_paclitaxel_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(12)00761-3 DB - PRIME DP - Unbound Medicine ER -