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CaReS (MACT) versus microfracture in treating symptomatic patellofemoral cartilage defects: a retrospective matched-pair analysis.
J Orthop Sci 2013; 18(1):38-44JO

Abstract

BACKGROUND

Treating patellofemoral articular cartilage lesions remains a challenging task in orthopedic surgery. Whereas microfracture and autologous chondrocyte implantation yield good results on femoral condyles, the therapeutic state of the art for treating patellofemoral lesions is yet to be determined. In this study, we compared the CaReS technique, which is a matrix-associated autologous chondrocyte implantation technique, to microfracture for treating patellofemoral articular cartilage lesions.

METHODS

Between May 2003 and December 2005, 17 patients with an isolated patellofemoral cartilage defect (International Cartilage Repair Society III/IV) were treated with the CaReS technique at our department. After adjusting for inclusion and exclusion criteria, ten of these patients could be included in this study; ten patients treated with microfracture were chosen as a matched-pair group. Clinical outcome was evaluated 3 years after surgery by the 36-item Short Form Health Survey Questionnaire (SF-36), International Knee Documentation Committee (IKDC) subjective evaluation of the knee, Lysholm Score, and Cincinnati Modified Rating Scale scores.

RESULTS

Patients treated with CaReS had statistically significantly improved IKDC, Lysholm, and Cincinnati scores 36 months after surgery compared with preoperatively. When comparing outcome between groups 36 months after surgery, there was no statistically difference in IKDC, Lysholm, and Cincinnati scores.

CONCLUSIONS

This is the first trial comparing the CaReS technique and microfracture for treating patellofemoral articular cartilage lesions, and results show that CaReS(®) yields comparable results to microfracture. The small number of patients is a limiting factor of the study, leading to results without statistical significance. A multicentric prospective randomized study comparing the two procedures is desirable.

Authors+Show Affiliations

Trauma Department, Hannover Medical School, Carl-Neuberg-Straβe 1, 30625 Hannover, Germany. petri.maximilian@mh-hannover.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23001127

Citation

Petri, Maximilian, et al. "CaReS (MACT) Versus Microfracture in Treating Symptomatic Patellofemoral Cartilage Defects: a Retrospective Matched-pair Analysis." Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association, vol. 18, no. 1, 2013, pp. 38-44.
Petri M, Broese M, Simon A, et al. CaReS (MACT) versus microfracture in treating symptomatic patellofemoral cartilage defects: a retrospective matched-pair analysis. J Orthop Sci. 2013;18(1):38-44.
Petri, M., Broese, M., Simon, A., Liodakis, E., Ettinger, M., Guenther, D., ... Haasper, C. (2013). CaReS (MACT) versus microfracture in treating symptomatic patellofemoral cartilage defects: a retrospective matched-pair analysis. Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association, 18(1), pp. 38-44. doi:10.1007/s00776-012-0305-x.
Petri M, et al. CaReS (MACT) Versus Microfracture in Treating Symptomatic Patellofemoral Cartilage Defects: a Retrospective Matched-pair Analysis. J Orthop Sci. 2013;18(1):38-44. PubMed PMID: 23001127.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CaReS (MACT) versus microfracture in treating symptomatic patellofemoral cartilage defects: a retrospective matched-pair analysis. AU - Petri,Maximilian, AU - Broese,Maximilian, AU - Simon,Annika, AU - Liodakis,Emmanouil, AU - Ettinger,Max, AU - Guenther,Daniel, AU - Zeichen,Johannes, AU - Krettek,Christian, AU - Jagodzinski,Michael, AU - Haasper,Carl, Y1 - 2012/09/22/ PY - 2012/01/31/received PY - 2012/08/17/accepted PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/7/17/medline SP - 38 EP - 44 JF - Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association JO - J Orthop Sci VL - 18 IS - 1 N2 - BACKGROUND: Treating patellofemoral articular cartilage lesions remains a challenging task in orthopedic surgery. Whereas microfracture and autologous chondrocyte implantation yield good results on femoral condyles, the therapeutic state of the art for treating patellofemoral lesions is yet to be determined. In this study, we compared the CaReS technique, which is a matrix-associated autologous chondrocyte implantation technique, to microfracture for treating patellofemoral articular cartilage lesions. METHODS: Between May 2003 and December 2005, 17 patients with an isolated patellofemoral cartilage defect (International Cartilage Repair Society III/IV) were treated with the CaReS technique at our department. After adjusting for inclusion and exclusion criteria, ten of these patients could be included in this study; ten patients treated with microfracture were chosen as a matched-pair group. Clinical outcome was evaluated 3 years after surgery by the 36-item Short Form Health Survey Questionnaire (SF-36), International Knee Documentation Committee (IKDC) subjective evaluation of the knee, Lysholm Score, and Cincinnati Modified Rating Scale scores. RESULTS: Patients treated with CaReS had statistically significantly improved IKDC, Lysholm, and Cincinnati scores 36 months after surgery compared with preoperatively. When comparing outcome between groups 36 months after surgery, there was no statistically difference in IKDC, Lysholm, and Cincinnati scores. CONCLUSIONS: This is the first trial comparing the CaReS technique and microfracture for treating patellofemoral articular cartilage lesions, and results show that CaReS(®) yields comparable results to microfracture. The small number of patients is a limiting factor of the study, leading to results without statistical significance. A multicentric prospective randomized study comparing the two procedures is desirable. SN - 1436-2023 UR - https://www.unboundmedicine.com/medline/citation/23001127/CaReS__MACT__versus_microfracture_in_treating_symptomatic_patellofemoral_cartilage_defects:_a_retrospective_matched_pair_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0949-2658(15)30539-X DB - PRIME DP - Unbound Medicine ER -