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Tissue Doppler imaging detects impaired biventricular performance shortly after congenital heart defect surgery.
Pediatr Cardiol. 2013 Mar; 34(3):630-8.PC

Abstract

Cardiac surgery with cardiopulmonary bypass is associated with the development of a systemic inflammatory response, which can lead to myocardial damage. However, knowledge concerning the time course of ventricular performance deterioration and restoration after correction of a congenital heart defect (CHD) in pediatric patients is sparse. Therefore, the authors perioperatively quantified left ventricular (LV) and right ventricular (RV) performance using echocardiography. Their study included 141 patients (ages 0-18 years) undergoing CHD correction and 40 control subjects. The study assessed LV systolic performance (fractional shortening) and diastolic performance (mitral Doppler flow) in combination with RV systolic performance [tricuspid annular plane systolic excursion (TAPSE)] and diastolic performance (tricuspid Doppler flow). Additionally, systolic (S') and diastolic (E', A', E/E') tissue Doppler imaging (TDI) measurements were obtained at the LV lateral wall, the interventricular septum, and the RV free wall. Echocardiographic studies were performed preoperatively, 1 day postoperatively, and at hospital discharge after 9 ± 5 days. Although all LV echocardiographic measurements showed a deterioration 1 day after surgery, only LV TDI measurements were impaired in patients at discharge versus control subjects (S': 5.7 ± 2.0 vs 7.1 ± 2.7 cm/s; E': 9.8 ± 3.9 vs 13.7 ± 5.1 cm/s; E/E': 12.2 ± 6.4 vs 8.8 ± 4.3; p < 0.05). In the RV, TAPSE and RV TDI velocities also were impaired in patients at discharge versus control subjects (TAPSE: 9 ± 3 vs 17 ± 5 mm; S': 5.2 ± 1.7 vs 11.4 ± 3.4 cm/s; E': 7.3 ± 2.5 vs 16.3 ± 5.2 cm/s; E/E': 12.5 ± 6.8 vs 4.8 ± 1.9; p < 0.05). Furthermore, longer aortic cross-clamp times were associated with more impaired postoperative LV and RV performance (p < 0.05). In conclusion, both systolic and diastolic biventricular performances were impaired shortly after CHD correction. This impairment was detected only by TDI parameters and TAPSE. Furthermore, a longer-lasting negative influence of cardiopulmonary bypass on myocardial performance was suggested.

Authors+Show Affiliations

Department of Pediatric Cardiology, Leiden University Medical Center, P.O. Box 9600, Room J6-S, 2300 RC, Leiden, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23001517

Citation

Klitsie, Liselotte M., et al. "Tissue Doppler Imaging Detects Impaired Biventricular Performance Shortly After Congenital Heart Defect Surgery." Pediatric Cardiology, vol. 34, no. 3, 2013, pp. 630-8.
Klitsie LM, Hazekamp MG, Roest AA, et al. Tissue Doppler imaging detects impaired biventricular performance shortly after congenital heart defect surgery. Pediatr Cardiol. 2013;34(3):630-8.
Klitsie, L. M., Hazekamp, M. G., Roest, A. A., Van der Hulst, A. E., Gesink-van der Veer, B. J., Kuipers, I. M., Blom, N. A., & Ten Harkel, A. D. (2013). Tissue Doppler imaging detects impaired biventricular performance shortly after congenital heart defect surgery. Pediatric Cardiology, 34(3), 630-8. https://doi.org/10.1007/s00246-012-0513-3
Klitsie LM, et al. Tissue Doppler Imaging Detects Impaired Biventricular Performance Shortly After Congenital Heart Defect Surgery. Pediatr Cardiol. 2013;34(3):630-8. PubMed PMID: 23001517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue Doppler imaging detects impaired biventricular performance shortly after congenital heart defect surgery. AU - Klitsie,Liselotte M, AU - Hazekamp,Mark G, AU - Roest,Arno A W, AU - Van der Hulst,Annelies E, AU - Gesink-van der Veer,Birthe J, AU - Kuipers,Irene M, AU - Blom,Nico A, AU - Ten Harkel,Arend D J, Y1 - 2012/09/22/ PY - 2012/04/12/received PY - 2012/08/29/accepted PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/9/21/medline SP - 630 EP - 8 JF - Pediatric cardiology JO - Pediatr Cardiol VL - 34 IS - 3 N2 - Cardiac surgery with cardiopulmonary bypass is associated with the development of a systemic inflammatory response, which can lead to myocardial damage. However, knowledge concerning the time course of ventricular performance deterioration and restoration after correction of a congenital heart defect (CHD) in pediatric patients is sparse. Therefore, the authors perioperatively quantified left ventricular (LV) and right ventricular (RV) performance using echocardiography. Their study included 141 patients (ages 0-18 years) undergoing CHD correction and 40 control subjects. The study assessed LV systolic performance (fractional shortening) and diastolic performance (mitral Doppler flow) in combination with RV systolic performance [tricuspid annular plane systolic excursion (TAPSE)] and diastolic performance (tricuspid Doppler flow). Additionally, systolic (S') and diastolic (E', A', E/E') tissue Doppler imaging (TDI) measurements were obtained at the LV lateral wall, the interventricular septum, and the RV free wall. Echocardiographic studies were performed preoperatively, 1 day postoperatively, and at hospital discharge after 9 ± 5 days. Although all LV echocardiographic measurements showed a deterioration 1 day after surgery, only LV TDI measurements were impaired in patients at discharge versus control subjects (S': 5.7 ± 2.0 vs 7.1 ± 2.7 cm/s; E': 9.8 ± 3.9 vs 13.7 ± 5.1 cm/s; E/E': 12.2 ± 6.4 vs 8.8 ± 4.3; p < 0.05). In the RV, TAPSE and RV TDI velocities also were impaired in patients at discharge versus control subjects (TAPSE: 9 ± 3 vs 17 ± 5 mm; S': 5.2 ± 1.7 vs 11.4 ± 3.4 cm/s; E': 7.3 ± 2.5 vs 16.3 ± 5.2 cm/s; E/E': 12.5 ± 6.8 vs 4.8 ± 1.9; p < 0.05). Furthermore, longer aortic cross-clamp times were associated with more impaired postoperative LV and RV performance (p < 0.05). In conclusion, both systolic and diastolic biventricular performances were impaired shortly after CHD correction. This impairment was detected only by TDI parameters and TAPSE. Furthermore, a longer-lasting negative influence of cardiopulmonary bypass on myocardial performance was suggested. SN - 1432-1971 UR - https://www.unboundmedicine.com/medline/citation/23001517/Tissue_Doppler_imaging_detects_impaired_biventricular_performance_shortly_after_congenital_heart_defect_surgery_ L2 - https://dx.doi.org/10.1007/s00246-012-0513-3 DB - PRIME DP - Unbound Medicine ER -