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Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements.
Mol Nutr Food Res 2013; 57(4):645-52MN

Abstract

SCOPE

Epidemiological studies on the association between pregnancy outcomes and use of periconceptional folic acid are often based on maternal reported intake. Use of folic acid during pregnancy is associated with a higher socioeconomic status known to have an impact on diet quality. We have studied plasma B vitamin status according to reported use of folic acid supplements during the periconceptional period in Norwegian women.

METHODS AND RESULTS

Plasma levels of folate, cobalamin, pyridoxal 5'-phosphate (vitamin B6), riboflavin, and the metabolic markers total homocysteine, methylmalonic acid and 3-hydro-xykynurenine were measured in pregnancy week 18 and related to reported intake of folic acid from 4 weeks prior to conception throughout week 18 in 2911 women from the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. Being a folic acid user during the periconceptional period was associated with a better socioeconomic status, and a higher intake of several micronutrients, including vitamins, trace-metals, and omega 3 fatty acids. Folic acid users had a significantly better plasma B vitamin status.

CONCLUSION

Epidemiological data based on maternal reported intake of folic acid supplements during pregnancy, should take into account the numerous nutritional implications, in addition to higher blood folate levels, of being a folic acid user.

Authors+Show Affiliations

Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway. almo@helse-bergen.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23001761

Citation

Bjørke-Monsen, Anne Lise, et al. "Maternal B Vitamin Status in Pregnancy Week 18 According to Reported Use of Folic Acid Supplements." Molecular Nutrition & Food Research, vol. 57, no. 4, 2013, pp. 645-52.
Bjørke-Monsen AL, Roth C, Magnus P, et al. Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements. Mol Nutr Food Res. 2013;57(4):645-52.
Bjørke-Monsen, A. L., Roth, C., Magnus, P., Midttun, Ø., Nilsen, R. M., Reichborn-Kjennerud, T., ... Ueland, P. M. (2013). Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements. Molecular Nutrition & Food Research, 57(4), pp. 645-52. doi:10.1002/mnfr.201200114.
Bjørke-Monsen AL, et al. Maternal B Vitamin Status in Pregnancy Week 18 According to Reported Use of Folic Acid Supplements. Mol Nutr Food Res. 2013;57(4):645-52. PubMed PMID: 23001761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal B vitamin status in pregnancy week 18 according to reported use of folic acid supplements. AU - Bjørke-Monsen,Anne Lise, AU - Roth,Christine, AU - Magnus,Per, AU - Midttun,Øivind, AU - Nilsen,Roy M, AU - Reichborn-Kjennerud,Ted, AU - Stoltenberg,Camilla, AU - Susser,Ezra, AU - Vollset,Stein Emil, AU - Ueland,Per Magne, Y1 - 2012/09/24/ PY - 2012/02/17/received PY - 2012/04/13/revised PY - 2012/06/20/accepted PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/10/30/medline SP - 645 EP - 52 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 57 IS - 4 N2 - SCOPE: Epidemiological studies on the association between pregnancy outcomes and use of periconceptional folic acid are often based on maternal reported intake. Use of folic acid during pregnancy is associated with a higher socioeconomic status known to have an impact on diet quality. We have studied plasma B vitamin status according to reported use of folic acid supplements during the periconceptional period in Norwegian women. METHODS AND RESULTS: Plasma levels of folate, cobalamin, pyridoxal 5'-phosphate (vitamin B6), riboflavin, and the metabolic markers total homocysteine, methylmalonic acid and 3-hydro-xykynurenine were measured in pregnancy week 18 and related to reported intake of folic acid from 4 weeks prior to conception throughout week 18 in 2911 women from the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. Being a folic acid user during the periconceptional period was associated with a better socioeconomic status, and a higher intake of several micronutrients, including vitamins, trace-metals, and omega 3 fatty acids. Folic acid users had a significantly better plasma B vitamin status. CONCLUSION: Epidemiological data based on maternal reported intake of folic acid supplements during pregnancy, should take into account the numerous nutritional implications, in addition to higher blood folate levels, of being a folic acid user. SN - 1613-4133 UR - https://www.unboundmedicine.com/medline/citation/23001761/Maternal_B_vitamin_status_in_pregnancy_week_18_according_to_reported_use_of_folic_acid_supplements_ L2 - https://doi.org/10.1002/mnfr.201200114 DB - PRIME DP - Unbound Medicine ER -