Tags

Type your tag names separated by a space and hit enter

Access to sultams by rhodium(III)-catalyzed directed C-H activation.
Angew Chem Int Ed Engl. 2012 Oct 15; 51(42):10610-4.AC

Abstract

Director's cut: The pharmaceutically relevant sulfonamide group is shown to be a competent directing group for [Cp*Rh(OAc)(2)]-catalyzed C-H functionalizations. Reactions of the cyclometalated intermediate with internal alkynes provide access to a wide range of sultam derivatives. The reaction is high yielding and works best under aerobic conditions with catalytic amounts of CuOAc as an oxidation mediator. Cp* = C(5)Me(5).

Authors+Show Affiliations

Laboratory of Asymmetric Catalysis and Synthesis, EPFL SB ISIC LCSA, BCH 4305, CH-1015 Lausanne, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23002028

Citation

Pham, Manh V., et al. "Access to Sultams By rhodium(III)-catalyzed Directed C-H Activation." Angewandte Chemie (International Ed. in English), vol. 51, no. 42, 2012, pp. 10610-4.
Pham MV, Ye B, Cramer N. Access to sultams by rhodium(III)-catalyzed directed C-H activation. Angew Chem Int Ed Engl. 2012;51(42):10610-4.
Pham, M. V., Ye, B., & Cramer, N. (2012). Access to sultams by rhodium(III)-catalyzed directed C-H activation. Angewandte Chemie (International Ed. in English), 51(42), 10610-4. https://doi.org/10.1002/anie.201206191
Pham MV, Ye B, Cramer N. Access to Sultams By rhodium(III)-catalyzed Directed C-H Activation. Angew Chem Int Ed Engl. 2012 Oct 15;51(42):10610-4. PubMed PMID: 23002028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Access to sultams by rhodium(III)-catalyzed directed C-H activation. AU - Pham,Manh V, AU - Ye,Baihua, AU - Cramer,Nicolai, Y1 - 2012/09/23/ PY - 2012/08/02/received PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2013/5/23/medline SP - 10610 EP - 4 JF - Angewandte Chemie (International ed. in English) JO - Angew Chem Int Ed Engl VL - 51 IS - 42 N2 - Director's cut: The pharmaceutically relevant sulfonamide group is shown to be a competent directing group for [Cp*Rh(OAc)(2)]-catalyzed C-H functionalizations. Reactions of the cyclometalated intermediate with internal alkynes provide access to a wide range of sultam derivatives. The reaction is high yielding and works best under aerobic conditions with catalytic amounts of CuOAc as an oxidation mediator. Cp* = C(5)Me(5). SN - 1521-3773 UR - https://www.unboundmedicine.com/medline/citation/23002028/Access_to_sultams_by_rhodium_III__catalyzed_directed_C_H_activation_ L2 - https://doi.org/10.1002/anie.201206191 DB - PRIME DP - Unbound Medicine ER -