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Obstetric complications as risk factors for schizophrenia spectrum psychoses in offspring of mothers with psychotic disorder.
Schizophr Bull 2013; 39(5):1056-66SB

Abstract

BACKGROUND

Obstetric complications have predicted future development of schizophrenia in previous studies, but they are also more common in mothers with schizophrenia. The aims of this study were to compare the occurrence of obstetric complications in children of mothers with schizophrenia spectrum psychoses and control children, and to investigate whether obstetric complications predicted children's psychiatric morbidity.

METHOD

The Helsinki High-Risk (HR) Study monitors females born between 1916 and 1948 and treated for schizophrenia spectrum disorders in Helsinki psychiatric hospitals, their offspring born between 1941 and 1977, and controls. We examined information on obstetric complications and neonatal health of 271 HR and 242 control offspring. We compared the frequency of obstetric complications and neonatal health problems in the HR group vs controls and in HR children who later developed psychotic disorders vs healthy HR children. A Cox regression model was used to assess whether problems in pregnancy or delivery predicted psychiatric morbidity within the HR group.

RESULTS

Few differences between HR and control offspring were found in obstetric complications. Within the HR group, infections (hazard rate ratio [HRR] 3.73, 95% CI 1.27-11.01), hypertension during pregnancy (HRR 4.10, 95% CI 1.15-14.58), and placental abnormalities (HRR 4.09, 95% CI 1.59-10.49) were associated with elevated risk of schizophrenia spectrum psychoses.

CONCLUSIONS

Common medical problems during pregnancy were associated with increased risk of schizophrenia spectrum psychoses in offspring of mothers with schizophrenia spectrum psychoses. These results underline the role of the prenatal period in the development of schizophrenia and the importance of careful monitoring of pregnancies of mothers with psychotic disorder.

Authors+Show Affiliations

Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland. jaana.suvisaari@thl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

23002182

Citation

Suvisaari, Jaana M., et al. "Obstetric Complications as Risk Factors for Schizophrenia Spectrum Psychoses in Offspring of Mothers With Psychotic Disorder." Schizophrenia Bulletin, vol. 39, no. 5, 2013, pp. 1056-66.
Suvisaari JM, Taxell-Lassas V, Pankakoski M, et al. Obstetric complications as risk factors for schizophrenia spectrum psychoses in offspring of mothers with psychotic disorder. Schizophr Bull. 2013;39(5):1056-66.
Suvisaari, J. M., Taxell-Lassas, V., Pankakoski, M., Haukka, J. K., Lönnqvist, J. K., & Häkkinen, L. T. (2013). Obstetric complications as risk factors for schizophrenia spectrum psychoses in offspring of mothers with psychotic disorder. Schizophrenia Bulletin, 39(5), pp. 1056-66. doi:10.1093/schbul/sbs109.
Suvisaari JM, et al. Obstetric Complications as Risk Factors for Schizophrenia Spectrum Psychoses in Offspring of Mothers With Psychotic Disorder. Schizophr Bull. 2013;39(5):1056-66. PubMed PMID: 23002182.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Obstetric complications as risk factors for schizophrenia spectrum psychoses in offspring of mothers with psychotic disorder. AU - Suvisaari,Jaana M, AU - Taxell-Lassas,Virpi, AU - Pankakoski,Maiju, AU - Haukka,Jari K, AU - Lönnqvist,Jouko K, AU - Häkkinen,Laura T, Y1 - 2012/09/20/ PY - 2012/9/25/entrez PY - 2012/9/25/pubmed PY - 2014/4/23/medline KW - High-Risk Study KW - obstetric complications KW - prenatal infections KW - risk factors KW - schizophrenia SP - 1056 EP - 66 JF - Schizophrenia bulletin JO - Schizophr Bull VL - 39 IS - 5 N2 - BACKGROUND: Obstetric complications have predicted future development of schizophrenia in previous studies, but they are also more common in mothers with schizophrenia. The aims of this study were to compare the occurrence of obstetric complications in children of mothers with schizophrenia spectrum psychoses and control children, and to investigate whether obstetric complications predicted children's psychiatric morbidity. METHOD: The Helsinki High-Risk (HR) Study monitors females born between 1916 and 1948 and treated for schizophrenia spectrum disorders in Helsinki psychiatric hospitals, their offspring born between 1941 and 1977, and controls. We examined information on obstetric complications and neonatal health of 271 HR and 242 control offspring. We compared the frequency of obstetric complications and neonatal health problems in the HR group vs controls and in HR children who later developed psychotic disorders vs healthy HR children. A Cox regression model was used to assess whether problems in pregnancy or delivery predicted psychiatric morbidity within the HR group. RESULTS: Few differences between HR and control offspring were found in obstetric complications. Within the HR group, infections (hazard rate ratio [HRR] 3.73, 95% CI 1.27-11.01), hypertension during pregnancy (HRR 4.10, 95% CI 1.15-14.58), and placental abnormalities (HRR 4.09, 95% CI 1.59-10.49) were associated with elevated risk of schizophrenia spectrum psychoses. CONCLUSIONS: Common medical problems during pregnancy were associated with increased risk of schizophrenia spectrum psychoses in offspring of mothers with schizophrenia spectrum psychoses. These results underline the role of the prenatal period in the development of schizophrenia and the importance of careful monitoring of pregnancies of mothers with psychotic disorder. SN - 1745-1701 UR - https://www.unboundmedicine.com/medline/citation/23002182/Obstetric_complications_as_risk_factors_for_schizophrenia_spectrum_psychoses_in_offspring_of_mothers_with_psychotic_disorder_ L2 - https://academic.oup.com/schizophreniabulletin/article-lookup/doi/10.1093/schbul/sbs109 DB - PRIME DP - Unbound Medicine ER -