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Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial.

Abstract

RATIONALE

Pulmonary rehabilitation is an important treatment for patients with Chronic Obstructive Pulmonary Disease, who are often vitamin D deficient. As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease.

MATERIAL AND METHODS

This study is a post-hoc subgroup analysis of a larger randomized trial comparing a monthly dose of 100.000 IU of vitamin D with placebo to reduce exacerbations. 50 Subjects who followed a rehabilitation program during the trial are included in this analysis. We report changes from baseline in muscle strength and exercise performance between both study arms after 3 months of rehabilitation.

RESULTS

Vitamin D intervention resulted in significantly higher median vitamin D levels compared to placebo (51 [44-62] ng/ml vs 15 [13-30] ng/ml; p < 0.001). Patients receiving vitamin D had significantly larger improvements in inspiratory muscle strength (-11±12 cmH2O vs 0±14 cmH2O; p = 0.004) and maximal oxygen uptake (110±211 ml/min vs -20±187 ml/min; p = 0.029). Improvements in quadriceps strength (15±16 Nm) or six minutes walking distance (40±55 meter) were not significantly different from the effects in the placebo group (7±19 Nm and 11±74 meter; p>0.050).

CONCLUSION

High dose vitamin D supplementation during rehabilitation may have mild additional benefits to training.

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  • Authors+Show Affiliations

    ,

    Respiratory Division and Rehabilitation, Laboratory of Pneumology, University Hospital Gasthuisberg, KULeuven, Herestraat 49, Leuven, 3000, Belgium.

    , , , , , , ,

    Source

    Respiratory research 13: 2012 Sep 25 pg 84

    MeSH

    Aged
    Dietary Supplements
    Dose-Response Relationship, Drug
    Double-Blind Method
    Exercise Tolerance
    Female
    Forced Expiratory Volume
    Humans
    Male
    Middle Aged
    Muscle Strength
    Muscle, Skeletal
    Oxygen Consumption
    Pulmonary Disease, Chronic Obstructive
    Treatment Outcome
    Vital Capacity
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    23006613

    Citation

    Hornikx, Miek, et al. "Vitamin D Supplementation During Rehabilitation in COPD: a Secondary Analysis of a Randomized Trial." Respiratory Research, vol. 13, 2012, p. 84.
    Hornikx M, Van Remoortel H, Lehouck A, et al. Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial. Respir Res. 2012;13:84.
    Hornikx, M., Van Remoortel, H., Lehouck, A., Mathieu, C., Maes, K., Gayan-Ramirez, G., ... Janssens, W. (2012). Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial. Respiratory Research, 13, p. 84. doi:10.1186/1465-9921-13-84.
    Hornikx M, et al. Vitamin D Supplementation During Rehabilitation in COPD: a Secondary Analysis of a Randomized Trial. Respir Res. 2012 Sep 25;13:84. PubMed PMID: 23006613.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial. AU - Hornikx,Miek, AU - Van Remoortel,Hans, AU - Lehouck,An, AU - Mathieu,Chantal, AU - Maes,Karen, AU - Gayan-Ramirez,Ghislaine, AU - Decramer,Marc, AU - Troosters,Thierry, AU - Janssens,Wim, Y1 - 2012/09/25/ PY - 2012/07/09/received PY - 2012/09/18/accepted PY - 2012/9/26/entrez PY - 2012/9/26/pubmed PY - 2013/6/21/medline SP - 84 EP - 84 JF - Respiratory research JO - Respir. Res. VL - 13 N2 - RATIONALE: Pulmonary rehabilitation is an important treatment for patients with Chronic Obstructive Pulmonary Disease, who are often vitamin D deficient. As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease. MATERIAL AND METHODS: This study is a post-hoc subgroup analysis of a larger randomized trial comparing a monthly dose of 100.000 IU of vitamin D with placebo to reduce exacerbations. 50 Subjects who followed a rehabilitation program during the trial are included in this analysis. We report changes from baseline in muscle strength and exercise performance between both study arms after 3 months of rehabilitation. RESULTS: Vitamin D intervention resulted in significantly higher median vitamin D levels compared to placebo (51 [44-62] ng/ml vs 15 [13-30] ng/ml; p < 0.001). Patients receiving vitamin D had significantly larger improvements in inspiratory muscle strength (-11±12 cmH2O vs 0±14 cmH2O; p = 0.004) and maximal oxygen uptake (110±211 ml/min vs -20±187 ml/min; p = 0.029). Improvements in quadriceps strength (15±16 Nm) or six minutes walking distance (40±55 meter) were not significantly different from the effects in the placebo group (7±19 Nm and 11±74 meter; p>0.050). CONCLUSION: High dose vitamin D supplementation during rehabilitation may have mild additional benefits to training. SN - 1465-993X UR - https://www.unboundmedicine.com/medline/citation/23006613/Vitamin_D_supplementation_during_rehabilitation_in_COPD:_a_secondary_analysis_of_a_randomized_trial_ L2 - https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-13-84 DB - PRIME DP - Unbound Medicine ER -