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Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial.
Respir Res 2012; 13:84RR

Abstract

RATIONALE

Pulmonary rehabilitation is an important treatment for patients with Chronic Obstructive Pulmonary Disease, who are often vitamin D deficient. As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease.

MATERIAL AND METHODS

This study is a post-hoc subgroup analysis of a larger randomized trial comparing a monthly dose of 100.000 IU of vitamin D with placebo to reduce exacerbations. 50 Subjects who followed a rehabilitation program during the trial are included in this analysis. We report changes from baseline in muscle strength and exercise performance between both study arms after 3 months of rehabilitation.

RESULTS

Vitamin D intervention resulted in significantly higher median vitamin D levels compared to placebo (51 [44-62] ng/ml vs 15 [13-30] ng/ml; p < 0.001). Patients receiving vitamin D had significantly larger improvements in inspiratory muscle strength (-11±12 cmH2O vs 0±14 cmH2O; p = 0.004) and maximal oxygen uptake (110±211 ml/min vs -20±187 ml/min; p = 0.029). Improvements in quadriceps strength (15±16 Nm) or six minutes walking distance (40±55 meter) were not significantly different from the effects in the placebo group (7±19 Nm and 11±74 meter; p>0.050).

CONCLUSION

High dose vitamin D supplementation during rehabilitation may have mild additional benefits to training.

Authors+Show Affiliations

Respiratory Division and Rehabilitation, Laboratory of Pneumology, University Hospital Gasthuisberg, KULeuven, Herestraat 49, Leuven, 3000, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23006613

Citation

Hornikx, Miek, et al. "Vitamin D Supplementation During Rehabilitation in COPD: a Secondary Analysis of a Randomized Trial." Respiratory Research, vol. 13, 2012, p. 84.
Hornikx M, Van Remoortel H, Lehouck A, et al. Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial. Respir Res. 2012;13:84.
Hornikx, M., Van Remoortel, H., Lehouck, A., Mathieu, C., Maes, K., Gayan-Ramirez, G., ... Janssens, W. (2012). Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial. Respiratory Research, 13, p. 84. doi:10.1186/1465-9921-13-84.
Hornikx M, et al. Vitamin D Supplementation During Rehabilitation in COPD: a Secondary Analysis of a Randomized Trial. Respir Res. 2012 Sep 25;13:84. PubMed PMID: 23006613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation during rehabilitation in COPD: a secondary analysis of a randomized trial. AU - Hornikx,Miek, AU - Van Remoortel,Hans, AU - Lehouck,An, AU - Mathieu,Chantal, AU - Maes,Karen, AU - Gayan-Ramirez,Ghislaine, AU - Decramer,Marc, AU - Troosters,Thierry, AU - Janssens,Wim, Y1 - 2012/09/25/ PY - 2012/07/09/received PY - 2012/09/18/accepted PY - 2012/9/26/entrez PY - 2012/9/26/pubmed PY - 2013/6/21/medline SP - 84 EP - 84 JF - Respiratory research JO - Respir. Res. VL - 13 N2 - RATIONALE: Pulmonary rehabilitation is an important treatment for patients with Chronic Obstructive Pulmonary Disease, who are often vitamin D deficient. As vitamin D status is linked to skeletal muscle function, we aimed to explore if high dose vitamin D supplementation can improve the outcomes of rehabilitation in Chronic Obstructive Pulmonary Disease. MATERIAL AND METHODS: This study is a post-hoc subgroup analysis of a larger randomized trial comparing a monthly dose of 100.000 IU of vitamin D with placebo to reduce exacerbations. 50 Subjects who followed a rehabilitation program during the trial are included in this analysis. We report changes from baseline in muscle strength and exercise performance between both study arms after 3 months of rehabilitation. RESULTS: Vitamin D intervention resulted in significantly higher median vitamin D levels compared to placebo (51 [44-62] ng/ml vs 15 [13-30] ng/ml; p < 0.001). Patients receiving vitamin D had significantly larger improvements in inspiratory muscle strength (-11±12 cmH2O vs 0±14 cmH2O; p = 0.004) and maximal oxygen uptake (110±211 ml/min vs -20±187 ml/min; p = 0.029). Improvements in quadriceps strength (15±16 Nm) or six minutes walking distance (40±55 meter) were not significantly different from the effects in the placebo group (7±19 Nm and 11±74 meter; p>0.050). CONCLUSION: High dose vitamin D supplementation during rehabilitation may have mild additional benefits to training. SN - 1465-993X UR - https://www.unboundmedicine.com/medline/citation/23006613/Vitamin_D_supplementation_during_rehabilitation_in_COPD:_a_secondary_analysis_of_a_randomized_trial_ L2 - https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-13-84 DB - PRIME DP - Unbound Medicine ER -