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Nonuniform irradiation of the canine intestine. II. Dosimetry.
Radiat Res 1990; 121(1):54-62RR

Abstract

An experimental model has been developed for quantitative studies of radiobiological damage to the canine small intestine following partial-body nonuniform irradiation. Animals were irradiated with 60Co gamma rays to simulate the nonuniform irradiation which do occur in victims of radiation accidents. The model used a short source-to-surface distance for unilateral irradiations to produce a dose gradient of a factor of two laterally across the canine intestinal region. The remainder of the animal's body was shielded to prevent lethal damage to the bone marrow. In situ dosimetry measurements were made using thermoluminescent dosimeters to determine the radiation dose delivered as a function of position along a segment of the small intestine. This system made it possible to correlate the radiation dose delivered at a specific point along the small intestine with the macroscopic and microscopic appearance of the intestinal mucosa at that point, as determined by direct observation and biopsy using a fiberoptic endoscope. A key feature of this model is that dosimetry data for multiple sites, which receive a graded range of radiation doses, can be correlated with biological measurements to obtain a dose-response curve. This model is being used to evaluate the efficacy of new therapeutic procedures to improve survival following nonuniform irradiation.

Authors+Show Affiliations

Armed Forces Radiobiology Research Institute, Bethesda, Maryland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

2300669

Citation

Zeman, G H., et al. "Nonuniform Irradiation of the Canine Intestine. II. Dosimetry." Radiation Research, vol. 121, no. 1, 1990, pp. 54-62.
Zeman GH, Mohaupt TH, Taylor PL, et al. Nonuniform irradiation of the canine intestine. II. Dosimetry. Radiat Res. 1990;121(1):54-62.
Zeman, G. H., Mohaupt, T. H., Taylor, P. L., MacVittie, T. J., Dubois, A., & Vigneulle, R. M. (1990). Nonuniform irradiation of the canine intestine. II. Dosimetry. Radiation Research, 121(1), pp. 54-62.
Zeman GH, et al. Nonuniform Irradiation of the Canine Intestine. II. Dosimetry. Radiat Res. 1990;121(1):54-62. PubMed PMID: 2300669.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonuniform irradiation of the canine intestine. II. Dosimetry. AU - Zeman,G H, AU - Mohaupt,T H, AU - Taylor,P L, AU - MacVittie,T J, AU - Dubois,A, AU - Vigneulle,R M, PY - 1990/1/1/pubmed PY - 1990/1/1/medline PY - 1990/1/1/entrez SP - 54 EP - 62 JF - Radiation research JO - Radiat. Res. VL - 121 IS - 1 N2 - An experimental model has been developed for quantitative studies of radiobiological damage to the canine small intestine following partial-body nonuniform irradiation. Animals were irradiated with 60Co gamma rays to simulate the nonuniform irradiation which do occur in victims of radiation accidents. The model used a short source-to-surface distance for unilateral irradiations to produce a dose gradient of a factor of two laterally across the canine intestinal region. The remainder of the animal's body was shielded to prevent lethal damage to the bone marrow. In situ dosimetry measurements were made using thermoluminescent dosimeters to determine the radiation dose delivered as a function of position along a segment of the small intestine. This system made it possible to correlate the radiation dose delivered at a specific point along the small intestine with the macroscopic and microscopic appearance of the intestinal mucosa at that point, as determined by direct observation and biopsy using a fiberoptic endoscope. A key feature of this model is that dosimetry data for multiple sites, which receive a graded range of radiation doses, can be correlated with biological measurements to obtain a dose-response curve. This model is being used to evaluate the efficacy of new therapeutic procedures to improve survival following nonuniform irradiation. SN - 0033-7587 UR - https://www.unboundmedicine.com/medline/citation/2300669/Nonuniform_irradiation_of_the_canine_intestine._II._Dosimetry DB - PRIME DP - Unbound Medicine ER -