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Differences in the frequency of 23S rRNA gene mutations in Mycoplasma pneumoniae between children and adults with community-acquired pneumonia: clinical impact of mutations conferring macrolide resistance.
Antimicrob Agents Chemother. 2012 Dec; 56(12):6393-6.AA

Abstract

We investigated the frequency and clinical significance of macrolide resistance in adult and pediatric patients with community-acquired pneumonia from a Mycoplasma pneumoniae infection. The frequency of the A2063G mutation in the 23S rRNA gene was significantly higher in children than in adults (61.3% [19/31] and 13.3% [8/60], respectively; P < 0.001). Patients with macrolide-resistant M. pneumoniae infections showed a longer duration of fever (P = 0.021) and required a longer duration of antibiotic treatment (P = 0.007).

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Authors+Show Affiliations

Yoo SJ
Department of Laboratory Medicine, Inje University College of Medicine, Seoul, Republic of Korea.
Kim HB
No affiliation info available
Choi SH
No affiliation info available
Lee SO
No affiliation info available
Kim SH
No affiliation info available
Hong SB
No affiliation info available
Sung H
No affiliation info available
Kim MN
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsChildChild, PreschoolCommunity-Acquired InfectionsDNADrug Resistance, BacterialFemaleHumansInfantMacrolidesMaleMicrobial Sensitivity TestsMiddle AgedMutationMycoplasma pneumoniaeNasopharynxPneumonia, MycoplasmaPolymerase Chain ReactionRNA, Ribosomal, 23SYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23006753

Citation

Yoo, Soo Jin, et al. "Differences in the Frequency of 23S rRNA Gene Mutations in Mycoplasma Pneumoniae Between Children and Adults With Community-acquired Pneumonia: Clinical Impact of Mutations Conferring Macrolide Resistance." Antimicrobial Agents and Chemotherapy, vol. 56, no. 12, 2012, pp. 6393-6.
Yoo SJ, Kim HB, Choi SH, et al. Differences in the frequency of 23S rRNA gene mutations in Mycoplasma pneumoniae between children and adults with community-acquired pneumonia: clinical impact of mutations conferring macrolide resistance. Antimicrob Agents Chemother. 2012;56(12):6393-6.
Yoo, S. J., Kim, H. B., Choi, S. H., Lee, S. O., Kim, S. H., Hong, S. B., Sung, H., & Kim, M. N. (2012). Differences in the frequency of 23S rRNA gene mutations in Mycoplasma pneumoniae between children and adults with community-acquired pneumonia: clinical impact of mutations conferring macrolide resistance. Antimicrobial Agents and Chemotherapy, 56(12), 6393-6. https://doi.org/10.1128/AAC.01421-12
Yoo SJ, et al. Differences in the Frequency of 23S rRNA Gene Mutations in Mycoplasma Pneumoniae Between Children and Adults With Community-acquired Pneumonia: Clinical Impact of Mutations Conferring Macrolide Resistance. Antimicrob Agents Chemother. 2012;56(12):6393-6. PubMed PMID: 23006753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in the frequency of 23S rRNA gene mutations in Mycoplasma pneumoniae between children and adults with community-acquired pneumonia: clinical impact of mutations conferring macrolide resistance. AU - Yoo,Soo Jin, AU - Kim,Hyo-Bin, AU - Choi,Sang-Ho, AU - Lee,Sang-Oh, AU - Kim,Sung-Han, AU - Hong,Sang-Bum, AU - Sung,Heungsup, AU - Kim,Mi-Na, Y1 - 2012/09/24/ PY - 2012/9/26/entrez PY - 2012/9/26/pubmed PY - 2013/3/1/medline SP - 6393 EP - 6 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 56 IS - 12 N2 - We investigated the frequency and clinical significance of macrolide resistance in adult and pediatric patients with community-acquired pneumonia from a Mycoplasma pneumoniae infection. The frequency of the A2063G mutation in the 23S rRNA gene was significantly higher in children than in adults (61.3% [19/31] and 13.3% [8/60], respectively; P < 0.001). Patients with macrolide-resistant M. pneumoniae infections showed a longer duration of fever (P = 0.021) and required a longer duration of antibiotic treatment (P = 0.007). SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/23006753/Differences_in_the_frequency_of_23S_rRNA_gene_mutations_in_Mycoplasma_pneumoniae_between_children_and_adults_with_community_acquired_pneumonia:_clinical_impact_of_mutations_conferring_macrolide_resistance_ L2 - https://journals.asm.org/doi/10.1128/AAC.01421-12?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -