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Phytochemical screening and antimicrobial activity of Coccinia cordifolia L. plant.
Pak J Pharm Sci. 2012 Oct; 25(4):757-61.PJ

Abstract

The medicinal plant, Coccinia cordifolia L. was analyzed for its chemical composition. The antimicrobial activities of the methanol, water, ethanol and ethyl acetate extracts of Coccinia cordifolia L. plant were evaluated against some Gram positive bacteria (Sarcina lutea, Bacillus subtilis and Staphylococcus aureus), Gram negative bacteria (Salmonella typhi, Shigella dysenteriae and Escherichia coli) and fungi (Candida albicans, Aspergillus niger and Penicillium notatum). Chemical analysis showed that the plant is rich in nutrients, especially antioxidant compounds such as total phenol, vitamin C and β-carotene. Phytochemical screening showed that the methanolic extract contains the bioactive constituents such as tannins, saponins, phenols, flavonoids and terpenoids. In the methanolic extract of the plant, promising antimicrobial potential was observed against the tested microorganism. Methanolic extract showed highest activity against Shigella dysenteriae, Escherichia coli, Staphylococcus aureus, and Candida albicans compared to the other extracts. Water extract showed less antimicrobial activity as compared to other extractants.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

23009991

Citation

Khatun, Shahanaz, et al. "Phytochemical Screening and Antimicrobial Activity of Coccinia Cordifolia L. Plant." Pakistan Journal of Pharmaceutical Sciences, vol. 25, no. 4, 2012, pp. 757-61.
Khatun S, Pervin F, Karim MR, et al. Phytochemical screening and antimicrobial activity of Coccinia cordifolia L. plant. Pak J Pharm Sci. 2012;25(4):757-61.
Khatun, S., Pervin, F., Karim, M. R., Ashraduzzaman, M., & Rosma, A. (2012). Phytochemical screening and antimicrobial activity of Coccinia cordifolia L. plant. Pakistan Journal of Pharmaceutical Sciences, 25(4), 757-61.
Khatun S, et al. Phytochemical Screening and Antimicrobial Activity of Coccinia Cordifolia L. Plant. Pak J Pharm Sci. 2012;25(4):757-61. PubMed PMID: 23009991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phytochemical screening and antimicrobial activity of Coccinia cordifolia L. plant. AU - Khatun,Shahanaz, AU - Pervin,Farzana, AU - Karim,Mohammad Rezaul, AU - Ashraduzzaman,Mohammad, AU - Rosma,Ahmad, PY - 2012/9/27/entrez PY - 2012/9/27/pubmed PY - 2012/12/12/medline SP - 757 EP - 61 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 25 IS - 4 N2 - The medicinal plant, Coccinia cordifolia L. was analyzed for its chemical composition. The antimicrobial activities of the methanol, water, ethanol and ethyl acetate extracts of Coccinia cordifolia L. plant were evaluated against some Gram positive bacteria (Sarcina lutea, Bacillus subtilis and Staphylococcus aureus), Gram negative bacteria (Salmonella typhi, Shigella dysenteriae and Escherichia coli) and fungi (Candida albicans, Aspergillus niger and Penicillium notatum). Chemical analysis showed that the plant is rich in nutrients, especially antioxidant compounds such as total phenol, vitamin C and β-carotene. Phytochemical screening showed that the methanolic extract contains the bioactive constituents such as tannins, saponins, phenols, flavonoids and terpenoids. In the methanolic extract of the plant, promising antimicrobial potential was observed against the tested microorganism. Methanolic extract showed highest activity against Shigella dysenteriae, Escherichia coli, Staphylococcus aureus, and Candida albicans compared to the other extracts. Water extract showed less antimicrobial activity as compared to other extractants. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/23009991/Phytochemical_screening_and_antimicrobial_activity_of_Coccinia_cordifolia_L__plant_ DB - PRIME DP - Unbound Medicine ER -