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Lithium and valproate modulate energy metabolism in an animal model of mania induced by methamphetamine.
Pharmacol Biochem Behav 2013; 103(3):589-96PB

Abstract

Studies have shown alterations in mitochondrial complexes of bipolar disorder (BD) patients. However, changes in the Krebs cycle enzymes have been little studied. The animal model of mania induced by amphetamine has been widely used for the study of bipolar mania. The aim of this study is to assess behavioral and energy metabolism changes in an animal model of mania induced by methamphetamine (m-AMPH). Wistar rats were first given m-AMPH or saline for 14 days, and then, between days 8 and 14, rats were treated with lithium (Li), valproate (VPA), or saline (Sal). Locomotor behavior was assessed using the open-field task and activities of Krebs cycle enzymes (citrate synthase and succinate dehydrogenase), mitochondrial respiratory chain complexes (I, II, III, and IV), and creatine kinase measured in the brain structures (prefrontal, amygdala, hippocampus, and striatum). Li and VPA reversed m-AMPH-induced hyperactivity. The administration of m-AMPH inhibited the activities of Krebs cycle enzymes and complexes of the mitochondrial respiratory chain in all analyzed structures. Li and VPA reversed m-AMPH-induced energetic metabolism dysfunction; however, the effects of Li and VPA were dependent on the brain region analyzed. From the results obtained in this study, we suggested that the decreased Krebs cycle enzymes activity induced by m-AMPH may be inhibiting mitochondrial respiratory chain complexes. Therefore, changes in the Krebs cycle enzymes may also be involved in BD.

Authors+Show Affiliations

Laboratory of Neurosciences, National Institute for Translational Medicine, and Center of Excellence in Applied Neurosciences of Santa Catarina, Postgraduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, 88806-000 Criciúma, SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23010382

Citation

Feier, Gustavo, et al. "Lithium and Valproate Modulate Energy Metabolism in an Animal Model of Mania Induced By Methamphetamine." Pharmacology, Biochemistry, and Behavior, vol. 103, no. 3, 2013, pp. 589-96.
Feier G, Valvassori SS, Varela RB, et al. Lithium and valproate modulate energy metabolism in an animal model of mania induced by methamphetamine. Pharmacol Biochem Behav. 2013;103(3):589-96.
Feier, G., Valvassori, S. S., Varela, R. B., Resende, W. R., Bavaresco, D. V., Morais, M. O., ... Quevedo, J. (2013). Lithium and valproate modulate energy metabolism in an animal model of mania induced by methamphetamine. Pharmacology, Biochemistry, and Behavior, 103(3), pp. 589-96. doi:10.1016/j.pbb.2012.09.010.
Feier G, et al. Lithium and Valproate Modulate Energy Metabolism in an Animal Model of Mania Induced By Methamphetamine. Pharmacol Biochem Behav. 2013;103(3):589-96. PubMed PMID: 23010382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lithium and valproate modulate energy metabolism in an animal model of mania induced by methamphetamine. AU - Feier,Gustavo, AU - Valvassori,Samira S, AU - Varela,Roger B, AU - Resende,Wilson R, AU - Bavaresco,Daniela V, AU - Morais,Meline O, AU - Scaini,Giselli, AU - Andersen,Monica L, AU - Streck,Emilio L, AU - Quevedo,João, Y1 - 2012/09/23/ PY - 2012/07/16/received PY - 2012/09/07/revised PY - 2012/09/16/accepted PY - 2012/9/27/entrez PY - 2012/9/27/pubmed PY - 2013/7/10/medline SP - 589 EP - 96 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 103 IS - 3 N2 - Studies have shown alterations in mitochondrial complexes of bipolar disorder (BD) patients. However, changes in the Krebs cycle enzymes have been little studied. The animal model of mania induced by amphetamine has been widely used for the study of bipolar mania. The aim of this study is to assess behavioral and energy metabolism changes in an animal model of mania induced by methamphetamine (m-AMPH). Wistar rats were first given m-AMPH or saline for 14 days, and then, between days 8 and 14, rats were treated with lithium (Li), valproate (VPA), or saline (Sal). Locomotor behavior was assessed using the open-field task and activities of Krebs cycle enzymes (citrate synthase and succinate dehydrogenase), mitochondrial respiratory chain complexes (I, II, III, and IV), and creatine kinase measured in the brain structures (prefrontal, amygdala, hippocampus, and striatum). Li and VPA reversed m-AMPH-induced hyperactivity. The administration of m-AMPH inhibited the activities of Krebs cycle enzymes and complexes of the mitochondrial respiratory chain in all analyzed structures. Li and VPA reversed m-AMPH-induced energetic metabolism dysfunction; however, the effects of Li and VPA were dependent on the brain region analyzed. From the results obtained in this study, we suggested that the decreased Krebs cycle enzymes activity induced by m-AMPH may be inhibiting mitochondrial respiratory chain complexes. Therefore, changes in the Krebs cycle enzymes may also be involved in BD. SN - 1873-5177 UR - https://www.unboundmedicine.com/medline/citation/23010382/Lithium_and_valproate_modulate_energy_metabolism_in_an_animal_model_of_mania_induced_by_methamphetamine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(12)00268-7 DB - PRIME DP - Unbound Medicine ER -