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Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats.
An Acad Bras Cienc. 2012 Dec; 84(4):1091-104.AA

Abstract

The present study was designed to investigate the ameliorative role of ethanolic extract from leaves of Butea monosperma in chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain in rats. Hot plate, acetone drop, paw pressure, Von Frey hair and tail immersion tests were performed to assess the degree of thermal hyperalgesia, cold chemical allodynia, mechanical hyperalgesia & allodynia in the left hind paw and tail thermal hyperalgesia. Further on, thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and total calcium levels were estimated to assess the biochemical changes in the sciatic nerve tissue. Histopathological changes were also observed in the sciatic nerve tissue. Ethanolic extract of Butea monosperma leaves and pregabalin (serving as positive control) were administered for 14 consecutive days starting from the day of surgery. CCI resulted in significant changes in behavioural and biochemical parameters. Pretreatment of Butea monosperma attenuated CCI induced development of behavioural, biochemical and histopathological alterations in a dose dependent manner, which is comparable to that of pregabalin pretreated group. These findings may be attributed to its potential anti-oxidative, neuroprotective and calcium channel modulatory actions of Butea monosperma.

Authors+Show Affiliations

School of Chemical and Biotechnology, Sastra University, Thanjavur, Tamilnadu, India. vrkmmcmadurai@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23011113

Citation

Thiagarajan, Venkata R K., et al. "Ameliorative Potential of Butea Monosperma On Chronic Constriction Injury of Sciatic Nerve Induced Neuropathic Pain in Rats." Anais Da Academia Brasileira De Ciencias, vol. 84, no. 4, 2012, pp. 1091-104.
Thiagarajan VR, Shanmugam P, Krishnan UM, et al. Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats. An Acad Bras Cienc. 2012;84(4):1091-104.
Thiagarajan, V. R., Shanmugam, P., Krishnan, U. M., Muthuraman, A., & Singh, N. (2012). Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats. Anais Da Academia Brasileira De Ciencias, 84(4), 1091-104.
Thiagarajan VR, et al. Ameliorative Potential of Butea Monosperma On Chronic Constriction Injury of Sciatic Nerve Induced Neuropathic Pain in Rats. An Acad Bras Cienc. 2012;84(4):1091-104. PubMed PMID: 23011113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats. AU - Thiagarajan,Venkata R K, AU - Shanmugam,Palanichamy, AU - Krishnan,Uma M, AU - Muthuraman,Arunachalam, AU - Singh,Nirmal, Y1 - 2012/09/25/ PY - 2011/07/12/received PY - 2012/04/13/accepted PY - 2012/9/27/entrez PY - 2012/9/27/pubmed PY - 2013/7/13/medline SP - 1091 EP - 104 JF - Anais da Academia Brasileira de Ciencias JO - An Acad Bras Cienc VL - 84 IS - 4 N2 - The present study was designed to investigate the ameliorative role of ethanolic extract from leaves of Butea monosperma in chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain in rats. Hot plate, acetone drop, paw pressure, Von Frey hair and tail immersion tests were performed to assess the degree of thermal hyperalgesia, cold chemical allodynia, mechanical hyperalgesia & allodynia in the left hind paw and tail thermal hyperalgesia. Further on, thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and total calcium levels were estimated to assess the biochemical changes in the sciatic nerve tissue. Histopathological changes were also observed in the sciatic nerve tissue. Ethanolic extract of Butea monosperma leaves and pregabalin (serving as positive control) were administered for 14 consecutive days starting from the day of surgery. CCI resulted in significant changes in behavioural and biochemical parameters. Pretreatment of Butea monosperma attenuated CCI induced development of behavioural, biochemical and histopathological alterations in a dose dependent manner, which is comparable to that of pregabalin pretreated group. These findings may be attributed to its potential anti-oxidative, neuroprotective and calcium channel modulatory actions of Butea monosperma. SN - 1678-2690 UR - https://www.unboundmedicine.com/medline/citation/23011113/Ameliorative_potential_of_Butea_monosperma_on_chronic_constriction_injury_of_sciatic_nerve_induced_neuropathic_pain_in_rats_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012005000063&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -