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Ginkgo biloba extract attenuates hyperalgesia in a rat model of vincristine-induced peripheral neuropathy.
Anesth Analg. 2012 Nov; 115(5):1228-33.A&A

Abstract

BACKGROUND

Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of cancer chemotherapeutic drugs. Hyperalgesia is a common component of neuropathic pain. Ginkgo biloba extract (GBE) is an oriental herbal medicine that has various pharmacological actions. In this study, we evaluated the effects of oral GBE on hyperalgesia in a rat model of vincristine-induced neuropathy.

METHODS

Male Sprague-Dawley rats (200-250 g) were injected intraperitoneally with vincristine or saline (0.1 mg/kg/d) using a 5-day-on, 2-day-off schedule over 12 days. All the behavioral tests for mechanical, cold, and heat hyperalgesia were conducted before the daily injection during the course of vincristine treatment. Rats that developed hyperalgesia 14 days after vincristine injection were randomly assigned into 4 groups. Distilled water and GBE (50, 100, and 150 mg/kg) were administered, respectively, to the individual groups. We examined the hyperalgesia at preadministration and at 15, 30, 60, 90, 120, 150, and 180 minutes after oral drug administration.

RESULTS

Saline injection did not have any significant effect on mechanical, cold, and heat hyperalgesia. Vincristine injection produced mechanical and cold hyperalgesia. For the GBE groups, the paw withdrawal threshold to mechanical stimuli was significantly increased and withdrawal frequency to cold stimuli was significantly reduced versus the control group dose-dependently (P < 0.05).

CONCLUSIONS

This study demonstrates that oral administration of GBE is associated with a dose-dependent antihyperalgesic effect on mechanical and cold stimuli in a rat model of vincristine-induced neuropathy.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, College of Medicine, The Catholic University of Korea, Seoul.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23011564

Citation

Park, Hue Jung, et al. "Ginkgo Biloba Extract Attenuates Hyperalgesia in a Rat Model of Vincristine-induced Peripheral Neuropathy." Anesthesia and Analgesia, vol. 115, no. 5, 2012, pp. 1228-33.
Park HJ, Lee HG, Kim YS, et al. Ginkgo biloba extract attenuates hyperalgesia in a rat model of vincristine-induced peripheral neuropathy. Anesth Analg. 2012;115(5):1228-33.
Park, H. J., Lee, H. G., Kim, Y. S., Lee, J. Y., Jeon, J. P., Park, C., & Moon, D. E. (2012). Ginkgo biloba extract attenuates hyperalgesia in a rat model of vincristine-induced peripheral neuropathy. Anesthesia and Analgesia, 115(5), 1228-33. https://doi.org/10.1213/ANE.0b013e318262e170
Park HJ, et al. Ginkgo Biloba Extract Attenuates Hyperalgesia in a Rat Model of Vincristine-induced Peripheral Neuropathy. Anesth Analg. 2012;115(5):1228-33. PubMed PMID: 23011564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ginkgo biloba extract attenuates hyperalgesia in a rat model of vincristine-induced peripheral neuropathy. AU - Park,Hue Jung, AU - Lee,Hyung Gon, AU - Kim,Yee Suk, AU - Lee,Jin Young, AU - Jeon,Joon Pyo, AU - Park,Chongmin, AU - Moon,Dong Eon, Y1 - 2012/09/25/ PY - 2012/9/27/entrez PY - 2012/9/27/pubmed PY - 2013/1/2/medline SP - 1228 EP - 33 JF - Anesthesia and analgesia JO - Anesth Analg VL - 115 IS - 5 N2 - BACKGROUND: Chemotherapy-induced peripheral neuropathy is a common, dose-limiting side effect of cancer chemotherapeutic drugs. Hyperalgesia is a common component of neuropathic pain. Ginkgo biloba extract (GBE) is an oriental herbal medicine that has various pharmacological actions. In this study, we evaluated the effects of oral GBE on hyperalgesia in a rat model of vincristine-induced neuropathy. METHODS: Male Sprague-Dawley rats (200-250 g) were injected intraperitoneally with vincristine or saline (0.1 mg/kg/d) using a 5-day-on, 2-day-off schedule over 12 days. All the behavioral tests for mechanical, cold, and heat hyperalgesia were conducted before the daily injection during the course of vincristine treatment. Rats that developed hyperalgesia 14 days after vincristine injection were randomly assigned into 4 groups. Distilled water and GBE (50, 100, and 150 mg/kg) were administered, respectively, to the individual groups. We examined the hyperalgesia at preadministration and at 15, 30, 60, 90, 120, 150, and 180 minutes after oral drug administration. RESULTS: Saline injection did not have any significant effect on mechanical, cold, and heat hyperalgesia. Vincristine injection produced mechanical and cold hyperalgesia. For the GBE groups, the paw withdrawal threshold to mechanical stimuli was significantly increased and withdrawal frequency to cold stimuli was significantly reduced versus the control group dose-dependently (P < 0.05). CONCLUSIONS: This study demonstrates that oral administration of GBE is associated with a dose-dependent antihyperalgesic effect on mechanical and cold stimuli in a rat model of vincristine-induced neuropathy. SN - 1526-7598 UR - https://www.unboundmedicine.com/medline/citation/23011564/Ginkgo_biloba_extract_attenuates_hyperalgesia_in_a_rat_model_of_vincristine_induced_peripheral_neuropathy_ L2 - https://doi.org/10.1213/ANE.0b013e318262e170 DB - PRIME DP - Unbound Medicine ER -