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Oxidative stress markers are increased since early stages of infection in syphilitic patients.
Arch Dermatol Res 2012; 304(9):689-97AD

Abstract

Clinical symptoms of syphilis are the consequence of the spirochete propensity to induce persistent chronic inflammation, which could participate to oxidative stress increase. The present study was designed to evaluate the level of oxidative stress biomarkers and antioxidant defences in a cohort of syphilitic patients. Serum oxidative status was explored in 63 patients diagnosed with early syphilis, 34 consulting patients negative for syphilis and 19 healthy controls. Total plasma thioredoxin (Trx) and thiols were determined as antioxidant capacity markers, °NO, advanced oxidation protein products (AOPP) and protein carbonyl levels as oxidative stress status biomarkers, and CRP as marker of inflammation. Mean serum levels of Trx, AOPP, carbonyls, and nitrates/nitrites were significantly higher, whereas thiols level was lower in syphilitic patients compared to non-syphilitic patients and healthy controls (respectively, p < 0.05/p < 0.01 for Trx, p < 0.005/p < 0.0001 for AOPP, p < 0.05/p < 0.005 for carbonyls, p < 0.005/p < 0.05 for nitrates/nitrites and p < 0.01/p < 0.0001 for thiols). According to the stage of the disease, results highlighted a marked and sustained oxidative stress imbalance from the first stage to the latent period of the disease. Moreover, syphilitic patients presented a low inflammation status reflected by median of CRP level (1.7 mg/L, range 5th-95th percentile from <0.1 to 33.7 mg/L), correlated with antioxidant capacity decrease (thiols) at stage 1 (r = -0.725; p < 0.0001) and nitrosative stress increase (nitrates/nitrites) at stage 2 and latent (respectively, r = 0.285, p < 0.05 and r = 0.650, p < 0.05). These findings indicate that at all stages of the disease, despite a low-grade inflammatory state, syphilis infection generates a major oxidative and nitrosative stress which may be involved in the pathophysiology of the disease.

Authors+Show Affiliations

EA 4466, Département de Biologie Expérimentale Métabolique et Clinique, Université Paris Descartes, Paris, France. marylise.hebert-schuster@cch.aphp.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23011658

Citation

Hébert-Schuster, Marylise, et al. "Oxidative Stress Markers Are Increased Since Early Stages of Infection in Syphilitic Patients." Archives of Dermatological Research, vol. 304, no. 9, 2012, pp. 689-97.
Hébert-Schuster M, Borderie D, Grange PA, et al. Oxidative stress markers are increased since early stages of infection in syphilitic patients. Arch Dermatol Res. 2012;304(9):689-97.
Hébert-Schuster, M., Borderie, D., Grange, P. A., Lemarechal, H., Kavian-Tessler, N., Batteux, F., & Dupin, N. (2012). Oxidative stress markers are increased since early stages of infection in syphilitic patients. Archives of Dermatological Research, 304(9), pp. 689-97. doi:10.1007/s00403-012-1271-z.
Hébert-Schuster M, et al. Oxidative Stress Markers Are Increased Since Early Stages of Infection in Syphilitic Patients. Arch Dermatol Res. 2012;304(9):689-97. PubMed PMID: 23011658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress markers are increased since early stages of infection in syphilitic patients. AU - Hébert-Schuster,Marylise, AU - Borderie,Didier, AU - Grange,Philippe A, AU - Lemarechal,Hervé, AU - Kavian-Tessler,Niloufar, AU - Batteux,Frédéric, AU - Dupin,Nicolas, Y1 - 2012/08/04/ PY - 2011/12/20/received PY - 2012/07/19/accepted PY - 2012/07/05/revised PY - 2012/9/27/entrez PY - 2012/9/27/pubmed PY - 2013/6/21/medline SP - 689 EP - 97 JF - Archives of dermatological research JO - Arch. Dermatol. Res. VL - 304 IS - 9 N2 - Clinical symptoms of syphilis are the consequence of the spirochete propensity to induce persistent chronic inflammation, which could participate to oxidative stress increase. The present study was designed to evaluate the level of oxidative stress biomarkers and antioxidant defences in a cohort of syphilitic patients. Serum oxidative status was explored in 63 patients diagnosed with early syphilis, 34 consulting patients negative for syphilis and 19 healthy controls. Total plasma thioredoxin (Trx) and thiols were determined as antioxidant capacity markers, °NO, advanced oxidation protein products (AOPP) and protein carbonyl levels as oxidative stress status biomarkers, and CRP as marker of inflammation. Mean serum levels of Trx, AOPP, carbonyls, and nitrates/nitrites were significantly higher, whereas thiols level was lower in syphilitic patients compared to non-syphilitic patients and healthy controls (respectively, p < 0.05/p < 0.01 for Trx, p < 0.005/p < 0.0001 for AOPP, p < 0.05/p < 0.005 for carbonyls, p < 0.005/p < 0.05 for nitrates/nitrites and p < 0.01/p < 0.0001 for thiols). According to the stage of the disease, results highlighted a marked and sustained oxidative stress imbalance from the first stage to the latent period of the disease. Moreover, syphilitic patients presented a low inflammation status reflected by median of CRP level (1.7 mg/L, range 5th-95th percentile from <0.1 to 33.7 mg/L), correlated with antioxidant capacity decrease (thiols) at stage 1 (r = -0.725; p < 0.0001) and nitrosative stress increase (nitrates/nitrites) at stage 2 and latent (respectively, r = 0.285, p < 0.05 and r = 0.650, p < 0.05). These findings indicate that at all stages of the disease, despite a low-grade inflammatory state, syphilis infection generates a major oxidative and nitrosative stress which may be involved in the pathophysiology of the disease. SN - 1432-069X UR - https://www.unboundmedicine.com/medline/citation/23011658/Oxidative_stress_markers_are_increased_since_early_stages_of_infection_in_syphilitic_patients_ L2 - https://link.springer.com/article/10.1007/s00403-012-1271-z DB - PRIME DP - Unbound Medicine ER -