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Evaluation of experimental impact injury for inducing post-traumatic osteoarthritis in the metacarpophalangeal joints of horses.
Am J Vet Res. 2012 Oct; 73(10):1540-52.AJ

Abstract

OBJECTIVE

To determine whether a single contusive impact injury to the palmar aspect of the metacarpus would progress to post-traumatic osteoarthritis or palmar osteochondral disease in horses.

ANIMALS

12 horses.

PROCEDURES

In each horse, an impact injury was created on the palmar aspect of the medial metacarpal condyle of 1 randomly chosen limb with an impactor device under arthroscopic and fluoroscopic guidance. The opposite limb was sham operated as a control. A low to moderate amount of forced exercise was instituted, and horses were evaluated clinically via lameness examinations weekly for 5 months, then biweekly until endpoint, with synovial fluid analysis performed at 0, 1, 2, 3, 4, 6, 8, and 10 months and radiography at baseline and endpoint. Macroscopic examination, micro-CT, and sample collection for cartilage viability and sulfated glycosaminoglycan content, histologic evaluation, immunohistochemical analysis, and fluorochrome analysis were performed following euthanasia at 1 (3 horses), 4 (4), and 8 to 10 (5) months after surgery.

RESULTS

There was variability in impact lesion location, depth, and area on macroscopic inspection, but on histologic evaluation, cartilage defects were less variable. Mean sulfated glycosaminoglycan concentration from cartilage at the impact site was significantly lower than that at a similar site in control limbs. Higher concentrations of cartilage oligomeric matrix protein were observed in synovial fluid from impact-injured joints.

CONCLUSIONS AND CLINICAL RELEVANCE

The impact injury method caused mild focal osteoarthritic lesions in the metacarpophalangeal joint, but did not progress to palmar osteochondral disease at this site. Repeated injury is probably required for the development of palmar osteochondral disease.

Authors+Show Affiliations

Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada. ellen.rickey@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23013179

Citation

Rickey, Ellen J., et al. "Evaluation of Experimental Impact Injury for Inducing Post-traumatic Osteoarthritis in the Metacarpophalangeal Joints of Horses." American Journal of Veterinary Research, vol. 73, no. 10, 2012, pp. 1540-52.
Rickey EJ, Cruz AM, Trout DR, et al. Evaluation of experimental impact injury for inducing post-traumatic osteoarthritis in the metacarpophalangeal joints of horses. Am J Vet Res. 2012;73(10):1540-52.
Rickey, E. J., Cruz, A. M., Trout, D. R., McEwen, B. J., & Hurtig, M. B. (2012). Evaluation of experimental impact injury for inducing post-traumatic osteoarthritis in the metacarpophalangeal joints of horses. American Journal of Veterinary Research, 73(10), 1540-52.
Rickey EJ, et al. Evaluation of Experimental Impact Injury for Inducing Post-traumatic Osteoarthritis in the Metacarpophalangeal Joints of Horses. Am J Vet Res. 2012;73(10):1540-52. PubMed PMID: 23013179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of experimental impact injury for inducing post-traumatic osteoarthritis in the metacarpophalangeal joints of horses. AU - Rickey,Ellen J, AU - Cruz,Antonio M, AU - Trout,Donald R, AU - McEwen,Beverly J, AU - Hurtig,Mark B, PY - 2012/9/28/entrez PY - 2012/9/28/pubmed PY - 2013/2/21/medline SP - 1540 EP - 52 JF - American journal of veterinary research JO - Am. J. Vet. Res. VL - 73 IS - 10 N2 - OBJECTIVE: To determine whether a single contusive impact injury to the palmar aspect of the metacarpus would progress to post-traumatic osteoarthritis or palmar osteochondral disease in horses. ANIMALS: 12 horses. PROCEDURES: In each horse, an impact injury was created on the palmar aspect of the medial metacarpal condyle of 1 randomly chosen limb with an impactor device under arthroscopic and fluoroscopic guidance. The opposite limb was sham operated as a control. A low to moderate amount of forced exercise was instituted, and horses were evaluated clinically via lameness examinations weekly for 5 months, then biweekly until endpoint, with synovial fluid analysis performed at 0, 1, 2, 3, 4, 6, 8, and 10 months and radiography at baseline and endpoint. Macroscopic examination, micro-CT, and sample collection for cartilage viability and sulfated glycosaminoglycan content, histologic evaluation, immunohistochemical analysis, and fluorochrome analysis were performed following euthanasia at 1 (3 horses), 4 (4), and 8 to 10 (5) months after surgery. RESULTS: There was variability in impact lesion location, depth, and area on macroscopic inspection, but on histologic evaluation, cartilage defects were less variable. Mean sulfated glycosaminoglycan concentration from cartilage at the impact site was significantly lower than that at a similar site in control limbs. Higher concentrations of cartilage oligomeric matrix protein were observed in synovial fluid from impact-injured joints. CONCLUSIONS AND CLINICAL RELEVANCE: The impact injury method caused mild focal osteoarthritic lesions in the metacarpophalangeal joint, but did not progress to palmar osteochondral disease at this site. Repeated injury is probably required for the development of palmar osteochondral disease. SN - 1943-5681 UR - https://www.unboundmedicine.com/medline/citation/23013179/Evaluation_of_experimental_impact_injury_for_inducing_post_traumatic_osteoarthritis_in_the_metacarpophalangeal_joints_of_horses_ L2 - http://avmajournals.avma.org/doi/full/10.2460/ajvr.73.10.1540?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -