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Value of routine voiding cystourethrography after renal transplantation.
Am J Transplant. 2013 Jan; 13(1):130-5.AJ

Abstract

The impact of vesicoureteral reflux (VUR) on renal allograft outcomes is debatable, with small cohort studies reporting controversial results. The objective of this retrospective study was to evaluate long-term clinical effects of early VUR in a large cohort of kidney transplant patients. Posttransplantation voiding cystourethrography was used to evaluate 646 consecutive kidney transplant recipients before discharge. The study endpoints included VUR grade, death-censored graft or patient survival, renal function, proteinuria and occurrence of urinary tract infections (UTIs). Of the 646 recipients, 263 (40.7%) were diagnosed with VUR. VUR grade II was most common (19.8%), followed by grades III (10.2%), I (7.9%) and IV (2.8%). VUR was less common in transplantations performed by experienced compared to inexperienced surgeons (36% vs. 48%; p = 0.004). VUR did not affect death-censored graft or patient survival and was not associated with proteinuria or occurrence of UTIs. Patients with VUR had a lower eGFR at 1 year after transplantation than did patients without VUR (60 vs. 52 mL/min/1.73 m(2) ; p = 0.02), although this difference was not observed at 3 and 5 years after transplantation. We conclude that early VUR, a common finding among renal transplant patients, may not have a meaningful impact on long-term transplant outcomes.

Authors+Show Affiliations

Department of Urology, Medical University Vienna, Austria. markus.margreiter@meduniwien.ac.atNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23016801

Citation

Margreiter, M, et al. "Value of Routine Voiding Cystourethrography After Renal Transplantation." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 13, no. 1, 2013, pp. 130-5.
Margreiter M, Györi GP, Böhmig GA, et al. Value of routine voiding cystourethrography after renal transplantation. Am J Transplant. 2013;13(1):130-5.
Margreiter, M., Györi, G. P., Böhmig, G. A., Trubel, S., Mühlbacher, F., & Steininger, R. (2013). Value of routine voiding cystourethrography after renal transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 13(1), 130-5. https://doi.org/10.1111/j.1600-6143.2012.04284.x
Margreiter M, et al. Value of Routine Voiding Cystourethrography After Renal Transplantation. Am J Transplant. 2013;13(1):130-5. PubMed PMID: 23016801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Value of routine voiding cystourethrography after renal transplantation. AU - Margreiter,M, AU - Györi,G P, AU - Böhmig,G A, AU - Trubel,S, AU - Mühlbacher,F, AU - Steininger,R, Y1 - 2012/09/27/ PY - 2012/08/17/accepted PY - 2012/04/02/received PY - 2012/08/14/revised PY - 2012/9/29/entrez PY - 2012/9/29/pubmed PY - 2013/7/9/medline SP - 130 EP - 5 JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JO - Am. J. Transplant. VL - 13 IS - 1 N2 - The impact of vesicoureteral reflux (VUR) on renal allograft outcomes is debatable, with small cohort studies reporting controversial results. The objective of this retrospective study was to evaluate long-term clinical effects of early VUR in a large cohort of kidney transplant patients. Posttransplantation voiding cystourethrography was used to evaluate 646 consecutive kidney transplant recipients before discharge. The study endpoints included VUR grade, death-censored graft or patient survival, renal function, proteinuria and occurrence of urinary tract infections (UTIs). Of the 646 recipients, 263 (40.7%) were diagnosed with VUR. VUR grade II was most common (19.8%), followed by grades III (10.2%), I (7.9%) and IV (2.8%). VUR was less common in transplantations performed by experienced compared to inexperienced surgeons (36% vs. 48%; p = 0.004). VUR did not affect death-censored graft or patient survival and was not associated with proteinuria or occurrence of UTIs. Patients with VUR had a lower eGFR at 1 year after transplantation than did patients without VUR (60 vs. 52 mL/min/1.73 m(2) ; p = 0.02), although this difference was not observed at 3 and 5 years after transplantation. We conclude that early VUR, a common finding among renal transplant patients, may not have a meaningful impact on long-term transplant outcomes. SN - 1600-6143 UR - https://www.unboundmedicine.com/medline/citation/23016801/full_citation/Value_of_Routine_Voiding_Cystourethrography_After_Renal_Transplantation_ L2 - https://doi.org/10.1111/j.1600-6143.2012.04284.x DB - PRIME DP - Unbound Medicine ER -