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Prognostic significance of fibroblastic foci in usual interstitial pneumonia and non-specific interstitial pneumonia.
Respirology. 2013 Feb; 18(2):278-83.R

Abstract

BACKGROUND AND OBJECTIVE

Fibroblastic foci (FF) composed of an accumulation of fibroblasts or myofibroblasts may be related to the progression of pulmonary fibrosis leading to respiratory insufficiency. Several studies have shown that the number of FF is a significant prognostic factor in usual interstitial pneumonia (UIP). The purpose of the present study was to examine whether the extent of FF is related to impairment of respiratory function and prognosis in patients with biopsy-proven fibrosing interstitial pneumonia, including UIP and fibrotic non-specific interstitial pneumonia (fNSIP).

METHODS

Fifty patients with histologically confirmed interstitial pneumonia including UIP or fNSIP were investigated, and correlations between FF and pulmonary function were evaluated. FF area was calculated as the proportion of total area (%FF) and the number of FF (FF/cm(2)) in the whole histological specimen from each patient.

RESULTS

The UIP group showed significantly higher %FF and FF/cm(2) than the fNSIP group. When UIP and fNSIP patients were analysed together, the group of patients who had died (death group) revealed significantly higher %FF and FF/cm(2) compared with the group of survivors, and the impairment of vital capacity and diffusing capacity of carbon monoxide was correlated with %FF and FF/cm(2).

CONCLUSIONS

FF correlated with impaired pulmonary function and may be a useful parameter to predict prognosis in patients with UIP and fNSIP.

Authors+Show Affiliations

Departments of Pathology, Fukuoka University School of Medicine, Fukuoka, Japan. haradata@adm.fukuoka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23016880

Citation

Harada, Taishi, et al. "Prognostic Significance of Fibroblastic Foci in Usual Interstitial Pneumonia and Non-specific Interstitial Pneumonia." Respirology (Carlton, Vic.), vol. 18, no. 2, 2013, pp. 278-83.
Harada T, Watanabe K, Nabeshima K, et al. Prognostic significance of fibroblastic foci in usual interstitial pneumonia and non-specific interstitial pneumonia. Respirology. 2013;18(2):278-83.
Harada, T., Watanabe, K., Nabeshima, K., Hamasaki, M., & Iwasaki, H. (2013). Prognostic significance of fibroblastic foci in usual interstitial pneumonia and non-specific interstitial pneumonia. Respirology (Carlton, Vic.), 18(2), 278-83. https://doi.org/10.1111/j.1440-1843.2012.02272.x
Harada T, et al. Prognostic Significance of Fibroblastic Foci in Usual Interstitial Pneumonia and Non-specific Interstitial Pneumonia. Respirology. 2013;18(2):278-83. PubMed PMID: 23016880.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of fibroblastic foci in usual interstitial pneumonia and non-specific interstitial pneumonia. AU - Harada,Taishi, AU - Watanabe,Kentaro, AU - Nabeshima,Kazuki, AU - Hamasaki,Makoto, AU - Iwasaki,Hiroshi, PY - 2012/9/29/entrez PY - 2012/9/29/pubmed PY - 2013/8/31/medline SP - 278 EP - 83 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 18 IS - 2 N2 - BACKGROUND AND OBJECTIVE: Fibroblastic foci (FF) composed of an accumulation of fibroblasts or myofibroblasts may be related to the progression of pulmonary fibrosis leading to respiratory insufficiency. Several studies have shown that the number of FF is a significant prognostic factor in usual interstitial pneumonia (UIP). The purpose of the present study was to examine whether the extent of FF is related to impairment of respiratory function and prognosis in patients with biopsy-proven fibrosing interstitial pneumonia, including UIP and fibrotic non-specific interstitial pneumonia (fNSIP). METHODS: Fifty patients with histologically confirmed interstitial pneumonia including UIP or fNSIP were investigated, and correlations between FF and pulmonary function were evaluated. FF area was calculated as the proportion of total area (%FF) and the number of FF (FF/cm(2)) in the whole histological specimen from each patient. RESULTS: The UIP group showed significantly higher %FF and FF/cm(2) than the fNSIP group. When UIP and fNSIP patients were analysed together, the group of patients who had died (death group) revealed significantly higher %FF and FF/cm(2) compared with the group of survivors, and the impairment of vital capacity and diffusing capacity of carbon monoxide was correlated with %FF and FF/cm(2). CONCLUSIONS: FF correlated with impaired pulmonary function and may be a useful parameter to predict prognosis in patients with UIP and fNSIP. SN - 1440-1843 UR - https://www.unboundmedicine.com/medline/citation/23016880/Prognostic_significance_of_fibroblastic_foci_in_usual_interstitial_pneumonia_and_non_specific_interstitial_pneumonia_ L2 - https://doi.org/10.1111/j.1440-1843.2012.02272.x DB - PRIME DP - Unbound Medicine ER -