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Plasma ω-3 fatty acid levels negatively and ω-6 fatty acid levels positively associated with other cardiovascular risk factors including homocysteine in severe obese subjects.
Asia Pac J Clin Nutr. 2012; 21(4):519-25.AP

Abstract

Obesity and homocysteine (tHcy) are important risk factors for cardiovascular diseases (CVD). Plasma omega-3 fatty acids (ω-3 FAs) and omega-6 fatty acids (ω-6 FAs) are essential fatty acids with diverse biological effects in human health and disease. We have investigated the relation of plasma ω-3 FAs and ω-6 FAs levels with other cardiovascular risk factors including tHcy in severe obese subjects. This study was performed on 96 severe obese and 65 normal weight subjects. Plasma fatty acid composition was measured by GC/MS and serum tHcy level was measured by HPLC methods. There were no differences between groups in terms of concentrations of serum tHcy, plasma ω-3 FAs, ω-6 FAs and ω-3/ω-6 ratio, whereas serum vitamin B-12 (p<0.01) and folic acid (p<0.05) levels were lower than those of the normal weight subjects. Homocysteine positively correlated with ω-6 FAs and negatively correlated with ω-3 FAs in severe obese and normal weight subjects. Serum vitamin B-12 positively correlated with ω-3 FAs (p<0.01) and ω-3/ω-6 ratio (p<0.01) and negatively correlated with ω-6 FAs (p<0.05) in severe obese subjects. Serum folic acid positively correlated with ω-3 FAs (p<0.01) in severe obese subjects. Our results suggest an association between the plasma ω-3 FAs and ω-6 FAs and serum tHcy concentrations in severe obese and normal weight subjects. Low levels vitamin B-12 and folic acid may have been responsible for the elevated tHcy levels in severe obese subjects, increasing the risk for future development of cardiovascular diseases.

Authors+Show Affiliations

University of N. Erbakan, Meram Faculty of Medicine, Department of Biochemistry, Konya, Turkey. fhumeyray@hotmail.com.tr.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

23017310

Citation

Mehmetoglu, Idris, et al. "Plasma Ω-3 Fatty Acid Levels Negatively and Ω-6 Fatty Acid Levels Positively Associated With Other Cardiovascular Risk Factors Including Homocysteine in Severe Obese Subjects." Asia Pacific Journal of Clinical Nutrition, vol. 21, no. 4, 2012, pp. 519-25.
Mehmetoglu I, Yerlikaya FH, Kurban S, et al. Plasma ω-3 fatty acid levels negatively and ω-6 fatty acid levels positively associated with other cardiovascular risk factors including homocysteine in severe obese subjects. Asia Pac J Clin Nutr. 2012;21(4):519-25.
Mehmetoglu, I., Yerlikaya, F. H., Kurban, S., & Polat, H. (2012). Plasma ω-3 fatty acid levels negatively and ω-6 fatty acid levels positively associated with other cardiovascular risk factors including homocysteine in severe obese subjects. Asia Pacific Journal of Clinical Nutrition, 21(4), 519-25.
Mehmetoglu I, et al. Plasma Ω-3 Fatty Acid Levels Negatively and Ω-6 Fatty Acid Levels Positively Associated With Other Cardiovascular Risk Factors Including Homocysteine in Severe Obese Subjects. Asia Pac J Clin Nutr. 2012;21(4):519-25. PubMed PMID: 23017310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma ω-3 fatty acid levels negatively and ω-6 fatty acid levels positively associated with other cardiovascular risk factors including homocysteine in severe obese subjects. AU - Mehmetoglu,Idris, AU - Yerlikaya,F Hümeyra, AU - Kurban,Sevil, AU - Polat,Hakkı, PY - 2012/9/29/entrez PY - 2012/9/29/pubmed PY - 2012/12/10/medline SP - 519 EP - 25 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 21 IS - 4 N2 - Obesity and homocysteine (tHcy) are important risk factors for cardiovascular diseases (CVD). Plasma omega-3 fatty acids (ω-3 FAs) and omega-6 fatty acids (ω-6 FAs) are essential fatty acids with diverse biological effects in human health and disease. We have investigated the relation of plasma ω-3 FAs and ω-6 FAs levels with other cardiovascular risk factors including tHcy in severe obese subjects. This study was performed on 96 severe obese and 65 normal weight subjects. Plasma fatty acid composition was measured by GC/MS and serum tHcy level was measured by HPLC methods. There were no differences between groups in terms of concentrations of serum tHcy, plasma ω-3 FAs, ω-6 FAs and ω-3/ω-6 ratio, whereas serum vitamin B-12 (p<0.01) and folic acid (p<0.05) levels were lower than those of the normal weight subjects. Homocysteine positively correlated with ω-6 FAs and negatively correlated with ω-3 FAs in severe obese and normal weight subjects. Serum vitamin B-12 positively correlated with ω-3 FAs (p<0.01) and ω-3/ω-6 ratio (p<0.01) and negatively correlated with ω-6 FAs (p<0.05) in severe obese subjects. Serum folic acid positively correlated with ω-3 FAs (p<0.01) in severe obese subjects. Our results suggest an association between the plasma ω-3 FAs and ω-6 FAs and serum tHcy concentrations in severe obese and normal weight subjects. Low levels vitamin B-12 and folic acid may have been responsible for the elevated tHcy levels in severe obese subjects, increasing the risk for future development of cardiovascular diseases. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/23017310/Plasma_ω_3_fatty_acid_levels_negatively_and_ω_6_fatty_acid_levels_positively_associated_with_other_cardiovascular_risk_factors_including_homocysteine_in_severe_obese_subjects_ L2 - http://apjcn.nhri.org.tw/server/APJCN/21/4/519.pdf DB - PRIME DP - Unbound Medicine ER -