Tags

Type your tag names separated by a space and hit enter

Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers.
AIDS. 2012 Nov 28; 26(18):2327-35.AIDS

Abstract

OBJECTIVE

The apolipoprotein E (APOE) ε4 allele enhances cerebral accumulation of β-amyloid (Aβ) and is a major risk factor for sporadic Alzheimer's disease. We hypothesized that HIV-associated neurocognitive disorders (HAND) would be associated with the APOE ε4 genotype and cerebral Aβ deposition.

DESIGN

Clinicopathological study of HIV-infected adults from four prospective cohorts in the US National NeuroAIDS Tissue Consortium.

METHODS

We used multivariable logistic regressions to model outcomes [Aβ plaques (immunohistochemistry) and HAND (standard criteria)] on predictors [APOE ε4 (allelic discrimination assay), older age (≥50 years), Aβ plaques, and their two-way interactions] and comorbid factors.

RESULTS

Isocortical Aβ deposits generally occurred as diffuse plaques and mild-to-moderate amyloid angiopathy. Isocortical phospho-Tau-immunoreactive neurofibrillary lesions were sparse. The APOE ε4 and older age were independently associated with the presence of Aβ plaques [adjusted odds ratio (OR) 10.16 and 5.77, 95% confidence interval (CI) 2.89 - 35.76 and 1.91-17.48, P = 0.0003 and 0.0019, respectively, n = 96]. The probability of HAND was increased in the presence of Aβ plaques among APOE ε4 carriers (adjusted OR 30.00, 95% CI 1.41-638.63, P = 0.029, n = 15), but not in non-ε4 carriers (n = 57).

CONCLUSION

The APOE ε4 and older age increased the likelihood of cerebral Aβ plaque deposition in HIV-infected adults. Generally, Aβ plaques in HIV brains were immunohistologically different from those in symptomatic Alzheimer's disease brains. Nonetheless, Aβ plaques were associated with HAND among APOE ε4 carriers. The detection of APOE ε4 genotype and cerebral Aβ deposition biomarkers may be useful in identifying living HAND patients who could benefit from Aβ-targeted therapies.

Authors+Show Affiliations

HIV Neurobehavioral Research Program and California NeuroAIDS Tissue Network, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23018443

Citation

Soontornniyomkij, Virawudh, et al. "Cerebral Β-amyloid Deposition Predicts HIV-associated Neurocognitive Disorders in APOE Ε4 Carriers." AIDS (London, England), vol. 26, no. 18, 2012, pp. 2327-35.
Soontornniyomkij V, Moore DJ, Gouaux B, et al. Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers. AIDS. 2012;26(18):2327-35.
Soontornniyomkij, V., Moore, D. J., Gouaux, B., Soontornniyomkij, B., Tatro, E. T., Umlauf, A., Masliah, E., Levine, A. J., Singer, E. J., Vinters, H. V., Gelman, B. B., Morgello, S., Cherner, M., Grant, I., & Achim, C. L. (2012). Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers. AIDS (London, England), 26(18), 2327-35. https://doi.org/10.1097/QAD.0b013e32835a117c
Soontornniyomkij V, et al. Cerebral Β-amyloid Deposition Predicts HIV-associated Neurocognitive Disorders in APOE Ε4 Carriers. AIDS. 2012 Nov 28;26(18):2327-35. PubMed PMID: 23018443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers. AU - Soontornniyomkij,Virawudh, AU - Moore,David J, AU - Gouaux,Ben, AU - Soontornniyomkij,Benchawanna, AU - Tatro,Erick T, AU - Umlauf,Anya, AU - Masliah,Eliezer, AU - Levine,Andrew J, AU - Singer,Elyse J, AU - Vinters,Harry V, AU - Gelman,Benjamin B, AU - Morgello,Susan, AU - Cherner,Mariana, AU - Grant,Igor, AU - Achim,Cristian L, PY - 2012/9/29/entrez PY - 2012/9/29/pubmed PY - 2013/6/5/medline SP - 2327 EP - 35 JF - AIDS (London, England) JO - AIDS VL - 26 IS - 18 N2 - OBJECTIVE: The apolipoprotein E (APOE) ε4 allele enhances cerebral accumulation of β-amyloid (Aβ) and is a major risk factor for sporadic Alzheimer's disease. We hypothesized that HIV-associated neurocognitive disorders (HAND) would be associated with the APOE ε4 genotype and cerebral Aβ deposition. DESIGN: Clinicopathological study of HIV-infected adults from four prospective cohorts in the US National NeuroAIDS Tissue Consortium. METHODS: We used multivariable logistic regressions to model outcomes [Aβ plaques (immunohistochemistry) and HAND (standard criteria)] on predictors [APOE ε4 (allelic discrimination assay), older age (≥50 years), Aβ plaques, and their two-way interactions] and comorbid factors. RESULTS: Isocortical Aβ deposits generally occurred as diffuse plaques and mild-to-moderate amyloid angiopathy. Isocortical phospho-Tau-immunoreactive neurofibrillary lesions were sparse. The APOE ε4 and older age were independently associated with the presence of Aβ plaques [adjusted odds ratio (OR) 10.16 and 5.77, 95% confidence interval (CI) 2.89 - 35.76 and 1.91-17.48, P = 0.0003 and 0.0019, respectively, n = 96]. The probability of HAND was increased in the presence of Aβ plaques among APOE ε4 carriers (adjusted OR 30.00, 95% CI 1.41-638.63, P = 0.029, n = 15), but not in non-ε4 carriers (n = 57). CONCLUSION: The APOE ε4 and older age increased the likelihood of cerebral Aβ plaque deposition in HIV-infected adults. Generally, Aβ plaques in HIV brains were immunohistologically different from those in symptomatic Alzheimer's disease brains. Nonetheless, Aβ plaques were associated with HAND among APOE ε4 carriers. The detection of APOE ε4 genotype and cerebral Aβ deposition biomarkers may be useful in identifying living HAND patients who could benefit from Aβ-targeted therapies. SN - 1473-5571 UR - https://www.unboundmedicine.com/medline/citation/23018443/Cerebral_β_amyloid_deposition_predicts_HIV_associated_neurocognitive_disorders_in_APOE_ε4_carriers_ L2 - http://Insights.ovid.com/pubmed?pmid=23018443 DB - PRIME DP - Unbound Medicine ER -