Tags

Type your tag names separated by a space and hit enter

Palladium-catalyzed regioselective [3 + 2] annulation of internal alkynes and iodo-pyranoquinolines with concomitant ring opening.
Org Lett. 2012 Oct 19; 14(20):5184-7.OL

Abstract

A regioselective tandem synthesis of highly functionalized pyrrolo[1,2-a]quinolines has been developed through a novel strategy by palladium-catalyzed [3 + 2] annulation of iodo-pyranoquinolines and internal alkynes with subsequent ring opening. Pyranoquinoline with n-alkyl substitution at the 3-position leads to the formation of pyrrolo-acridones via [3 + 2] annulations/ring opening and successive intramolecular cross-aldol condensation.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Aggarwal T
Department of Chemistry, University of Delhi, Delhi, 110007, India.
Jha RR
No affiliation info available
Tiwari RK
No affiliation info available
Kumar S
No affiliation info available
Kotla SK
No affiliation info available
Kumar S
No affiliation info available
Verma AK
No affiliation info available

MeSH

AlkynesCatalysisIndolesMolecular StructurePalladiumQuinolines

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

23020191

Citation

Aggarwal, Trapti, et al. "Palladium-catalyzed Regioselective [3 + 2] Annulation of Internal Alkynes and Iodo-pyranoquinolines With Concomitant Ring Opening." Organic Letters, vol. 14, no. 20, 2012, pp. 5184-7.
Aggarwal T, Jha RR, Tiwari RK, et al. Palladium-catalyzed regioselective [3 + 2] annulation of internal alkynes and iodo-pyranoquinolines with concomitant ring opening. Org Lett. 2012;14(20):5184-7.
Aggarwal, T., Jha, R. R., Tiwari, R. K., Kumar, S., Kotla, S. K., Kumar, S., & Verma, A. K. (2012). Palladium-catalyzed regioselective [3 + 2] annulation of internal alkynes and iodo-pyranoquinolines with concomitant ring opening. Organic Letters, 14(20), 5184-7. https://doi.org/10.1021/ol3022935
Aggarwal T, et al. Palladium-catalyzed Regioselective [3 + 2] Annulation of Internal Alkynes and Iodo-pyranoquinolines With Concomitant Ring Opening. Org Lett. 2012 Oct 19;14(20):5184-7. PubMed PMID: 23020191.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palladium-catalyzed regioselective [3 + 2] annulation of internal alkynes and iodo-pyranoquinolines with concomitant ring opening. AU - Aggarwal,Trapti, AU - Jha,Rajeev R, AU - Tiwari,Rakesh K, AU - Kumar,Sonu, AU - Kotla,Siva K Reddy, AU - Kumar,Sushil, AU - Verma,Akhilesh K, Y1 - 2012/09/28/ PY - 2012/10/2/entrez PY - 2012/10/2/pubmed PY - 2013/8/22/medline SP - 5184 EP - 7 JF - Organic letters JO - Org Lett VL - 14 IS - 20 N2 - A regioselective tandem synthesis of highly functionalized pyrrolo[1,2-a]quinolines has been developed through a novel strategy by palladium-catalyzed [3 + 2] annulation of iodo-pyranoquinolines and internal alkynes with subsequent ring opening. Pyranoquinoline with n-alkyl substitution at the 3-position leads to the formation of pyrrolo-acridones via [3 + 2] annulations/ring opening and successive intramolecular cross-aldol condensation. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/23020191/Palladium_catalyzed_regioselective_[3_+_2]_annulation_of_internal_alkynes_and_iodo_pyranoquinolines_with_concomitant_ring_opening_ L2 - https://doi.org/10.1021/ol3022935 DB - PRIME DP - Unbound Medicine ER -